Current Status of Conformal Radiotherapy

Dahl, Olav; Kardamakis, D.; Lind, Bengt K.; Rosenwald, J. C.

doi:10.3109/02841869609098520

Cited by 15 publications

(6 citation statements)

References 231 publications

(211 reference statements)

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13] There are, however, many unanswered questions about this new method of treatment delivery. The goal of this project has been the development of a test environment that provides a means for efficiently investigating some of the unresolved issues in IMRT.…”

Section: Introductionmentioning

confidence: 99%

A simple model for examining issues in radiotherapy optimization

Shepard¹,

Olivera²,

Angelos³

et al. 1999

Medical Physics

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Convolution/superposition software has been used to produce a library of photon pencil beam dose matrices. This library of pencil beams is designed to serve as a tool for both education and investigation in the field of radiotherapy optimization. The elegance of this pencil beam model stems from its cylindrical symmetry. Because of the symmetry, the dose distribution for a pencil beam from any arbitrary angle can be determined through a simple rotation of a pre-computed dose matrix. Rapid dose calculations can thus be performed while maintaining the accuracy of a convolution/superposition based dose computation. The pencil beam data sets have been made publicly available. It is hoped that the data sets will facilitate a comparison of a variety of optimization and delivery approaches. This paper will present a number of studies designed to demonstrate the usefulness of the pencil beam data sets. These studies include an examination of the extent to which a treatment plan can be improved through either an increase in the number of beam angles and/or a decrease in the collimator size. A few insights into the significance of heterogeneity corrections for treatment planning for intensity modulated radiotherapy will also be presented.

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Section: Introductionmentioning

confidence: 99%

A simple model for examining issues in radiotherapy optimization

Shepard¹,

Olivera²,

Angelos³

et al. 1999

Medical Physics

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“…But even though great achievements of CRT have been made in the recent years, tumor recurrence and metastasis are still insurmountable barriers in clinical practice, nearly 60% of malignant tumor patients suffer from tumor recurrence or metastasis within one year post CRT [ 14 – 20 ]. Generally, RT mainly induces necrosis and apoptosis of tumor cells, accompanied by some side effects including the damage to surrounding normal tissues and the immune system, especially with high dose of radiation [ 21 – 23 ]. Recently, it has discovered that vast necrosis within tumor cells always leads to the generation of excessive inflammatory factors, thus accelerating the recurrence and metastasis of the tumor [ 24 – 26 ].…”

Section: Introductionmentioning

confidence: 99%

Platinum prodrug nanoparticles inhibiting tumor recurrence and metastasis by concurrent chemoradiotherapy

et al. 2022

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Background Although concurrent chemoradiotherapy (CRT), as one of the most effective antineoplastic therapies in clinic, can successfully inhibit the growth of tumor cells, a risk of developing secondary tumor is still an insurmountable barrier in clinical practice. Results Herein, a new platinum prodrug composed of tannic acid (TA) and Pt2+ (TA-Pt) complex film was synthesized on the surface of Fe2O3 nanoparticles (NPs) with excellent stability and biocompatibility for enhanced CRT. In this system, TA-Pt complex could respond to the tumor acidic microenvironment and damage the DNA of tumor cells. Moreover, the internal iron core not only improved the effect of subsequent radiotherapy (RT), but also disrupted the iron balance in cells, inducing intracellular ferroptosis and eliminating apoptosis-resistant cells. In vitro and vivo experimental results indicated that more than 90% of tumor cells were depleted and more than 75% of the cured tumor-bearing mice evinced no recurrence or metastasis. Conclusions This work offered a new idea for combining the effective chemotherapy, RT and ferroptosis therapy to enhance the curative effect of CRT and inhibit tumor recurrence and metastasis. Graphical Abstract

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“…As pointed out by Dahl et al (15), the term 'conformal radiotherapy' is not very well defined. A number of papers appearing under the title of conformal radiotherapy have used completely different treatment techniques.…”

Section: Conformal Radiotherapymentioning

confidence: 99%

“…In order to compare the clinical gains of conformal radiotherapy, with respect to late toxicity and tumour control, it is important to have a common understanding of what is meant by a conformal radiotherapy technique. Dahl et al (15) have therefore suggested a classification of conformal radiotherapy according to the methodology and tools associated with each step of the entire procedure. As the conformity of the treatment technique increases, the margin between the target volume outline and the field borders decreases.…”

Section: Conformal Radiotherapymentioning

confidence: 99%