Current Status of Direct Acting Antiviral Agents against Hepatitis C Virus Infection in Pakistan

Abstract

In Pakistan, the burden of the hepatitis C virus (HCV) infection is the second highest in the world with the development of chronic hepatitis. Interferon-based combination therapy with ribavirin was the only available treatment until a few years back, with severe side-effects and high failure rates against different genotypes of HCV. Interferon-free all-oral direct-acting antiviral agents (DAAs) approved by the FDA have revolutionized the HCV therapeutic landscape due to their efficiency in targeting different genotypes in different categories of patients, including treatment naïve, treatment failure and relapsing patients, as well as patients with compensated and decompensated cirrhosis. The availability and use of these DAAs is limited in the developing world. Sofosbuvir (SOF), a uridine nucleotide analogue and inhibitor of HCV encoded NS5B polymerase, is now a widely available and in-use DAA in Pakistan; whereas daclatasvir was recently added in the list. According to the documented results, there is hope that this disease can be effectively cured in Pakistan, although a few concerns still remain. The aim of this article is to review the effectiveness of DAAs and the current status of this treatment against HCV genotype 3 infection in Pakistan; various factors associated with SVR; its limitations as an effective treatment regime; and future implications.

Efficacy and Safety of Sofosbuvir-Velpatasvir combination in Hepatitis C Virus-infected Pakistani Patients without Cirrhosis or with Compensated Cirrhosis: A Prospective, Open-label Interventional Trial

“…In the past decade, newer oral treatment regimens that act on nonstructural proteins have been introduced [7]. The use of direct-acting antiviral agents has resulted in cure rates of >90% regardless of liver fibrosis, previous treatment, or any demographic aspect [8].…”

Effectiveness of direct-acting antivirals in maintenance hemodialysis patients complicated with chronic hepatitis C

“…[ 8 ] Due to high efficiency, low drug resistance and high safety, direct-acting antivirals (DAAs) have become the first-line treatment option for chronic HCV as recommended by international guidelines. [ 9 , 10 ] Currently, it was shown that DAAs demonstrate good safety and efficacy in patients with renal impairment infected by HCV. [ 11 , 12 ] However, reports assessing the application of DAAs in hemodialysis patients complicated with hepatitis C in Chinese real-world setting are scare.…”

Thalassemia Patients from Baluchistan in Pakistan Are Infected with Multiple Hepatitis B or C Virus Strains

“…Because the efficient direct-acting antiviral drugs against HCV now are available in Pakistan, 42 β-thalassemia patients need to be treated. However, possible new recombinants may influence on this treatment and need to be monitored.…”