Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Susanna, Dewi; Pratiwi, Dian

doi:10.12688/f1000research.46883.1

Cited by 12 publications

(7 citation statements)

References 24 publications

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“…This study retrieved articles from four science databases, namely ProQuest , Science Direct , EBSCO , and PubMed , from December 2009 to December 2019. A systematic review was conducted using a predefined protocol based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) 11 , 12 . The searching process utilized four main combinations of the following keywords: “malaria”, “vector control”, “insecticide”, and “Asia”.…”

Section: Methodsmentioning

confidence: 99%

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Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Susanna

Pratiwi

2022

F1000Res

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Background: The application of insecticides for malaria vector control has led to a global problem, which is the current trend of increased resistance against these chemicals. This study aimed to review the insecticide resistance status was previously determined in Asia and how to implement the necessary interventions. Moreover, the implications of resistance in malaria vector control in this region were studied. Methods: This systematic review was conducted using a predefined protocol based on PRISMA-retrieved articles from four science databases, namely ProQuest, Science Direct, EBSCO, and PubMed in the last ten years (2009 to 2019). The searching process utilized four main combinations of the following keywords: malaria, vector control, insecticide, and Asia. In ProQuest, malaria control, as well as an insecticide, were used as keywords. The following criteria were included in the filter, namely full text, the source of each article, scholarly journal, Asia, and publication date as in the last ten years. Results: There were 1408 articles retrieved during the initial search (ProQuest=722, Science Direct=267, EBSCO=50, PubMed=285, and Scopus=84). During the screening, 27 articles were excluded because of duplication, 1361 based on title and abstract incompatibility with the inclusion criteria, and 20 due to content differences. In the final screening process, 15 articles were chosen to be analyzed. From the 15 articles, it is known that there was organochlorine (DDT), organophosphate (malathion), and pyrethroids resistance in several Anopheles species with a less than 80% mortality rate. Conclusion: This review found multiple resistance in several Anopheles includes resistance to pyrethroid. The reports of pyrethroid resistance were quite challenging because it is considered effective in the malaria vector control. Several countries in Asia are implementing an insecticide resistance management (IRM) strategy against malaria vectors following the Global Plan for IRM.

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Section: Methodsmentioning

confidence: 99%

“…Figshare: PRISMA checklist for ‘Current status of insecticide resistance in malaria vectors in the Asian countries: systematic review’. https://doi.org/10.6084/m9.figshare.13582517 12 .…”

Section: Data Availabilitymentioning

confidence: 99%

Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Susanna

Pratiwi

2022

F1000Res

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“…Studies have shown that insecticide resistance in malaria vector population is a global phenomenon, which is highly predominant in the sub-Saharan Africa (Kleinschmidt et al, 2018) [13] . Resistance has been reported in all the classes of insecticides recommended by WHO for public use namely; pyrethroids, organochlorines, carbamates and organophosphates (Susanna and Pratiwi, 2022; WHO, 2018) [26,28] . Significant amount of resistance was found in both DDT and pyrethroid in the present study, and this is consistent with the study by Nwankwo et al (2017) [19] in Amansea, Anambra State.…”

Section: Mortality Rate and Susceptibility Statusmentioning

confidence: 99%

Susceptibility status of Anopheles gambiae complex in NNEWI community, Anambra state

E¹,

N²,

N³

et al. 2022

Int. J. Mosq. Res.

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Insecticide resistance in Anopheles mosquito is a major concern for vector control interventions in Nigeria. The present base-line study was carried out in Nnewi community, Nnewi North L.G.A., Anambra State, South-east Nigeria to investigate the insecticide susceptibility status of wild Anopheles gambiae s.l. to the four classes of insecticide used in vector control interventions. Anopheles larvae collected from different breeding sites in the community were reared to adults in the insectary and were morphologically identified following standard protocols. Two to five-day old adult female mosquitoes were exposed to different doses of organochlorine (4% DDT), organophosphate (0.25% pirimiphosmethyl and 5.0% malathaion), carbamate (0.1% propoxur and 0.1% bendiocarb) and pyrethroid (0.05% deltamethrin, 0.75% permethrin) insecticides using WHO susceptibility assay protocol. Data generated were subjected to probit analysis and analysis of variance. The organochlorine insecticide (DDT) had the highest knockdown time KDT50 (113.8 minutes) and KDT95 (182.1 minutes) while the carbamate insecticide, bendiocarb had the least KDT50 (8.97 minutes) and KDT95 (28.78 minutes). The mosquitoes were totally susceptible to propoxur and bendiocarb. The two pyrethroid used (deltamethrin and permethrin) and organochlorine (DDT) recorded percentage mortalities of 17.5%, 43.75% and 11.25% respectively. The report of organochlorine and pyrethroid resistance in the study area calls for immediate implementation of management action in the study area. The study has also shown that carbamate insecticides may be a suitable alternative to mitigate pyrethroid resistance in mosquito population in the study area.

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“…The malaria control and elimination programme now relies mainly on two vector intervention tools, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS), that use insecticides to mitigate malaria transmission. The emergence of Anopheles strains resistant to currently used insecticides poses a critical challenge to achieving malaria elimination by 2030 [ 2 , 3 ]. Vector control is an essential aspect of the program to combat malaria transmitted by Anopheles .…”

Section: Introductionmentioning

confidence: 99%

Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia

Syahrani,

Asih,

Bowolaksono

et al. 2024

Malar J

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Background The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this residual transmission. With limited options for effective insecticides, regular resistance monitoring is warranted for selecting and using appropriate tools. This study evaluates the pyrethroid knockdown resistance (kdr) allele before and after implementing a transfluthrin-based spatial repellent (SR) intervention in placebo-treated clusters. Methods This study looks at the frequency distribution of the kdr allele in Sumba Island from June 2015 to August 2018. Insecticide susceptibility tests were carried out on female Anopheles sp. aged 3–5 days against permethrin 21.5 μg/ml, deltamethrin 12.5 μg/ml, and transfluthrin 10 μg/ml using CDC bottle assay. PCR sequencing of representative samples from adult mosquito collections and insecticide tests revealed the presence of kdr mutations (L1014F and L1014S) in the VGSC gene. Results A total of 12 Anopheles species, Anopheles tesselatus, Anopheles. aconitus, Anopheles barbirostris, Anopheles kochi, Anopheles annularis, Anopheles maculatus, Anopheles sundaicus, Anopheles flavirostris, Anopheles balabacensis, Anopheles indefinitus, Anopheles subpictus, and Anopheles vagus were analysed. Anopheles vagus and An. sundaicus predominated in the larval populations. Susceptibility assays for all insecticides identified fully susceptible phenotypes in all species examined. Anopheles increasing frequency of kdr mutant alleles during the 3 year SR deployment was observed in both SR-treated and placebo areas, a statistically significant increase occurred in each arm. However, it is unclear how significant SR is in causing the increase in mutant alleles. The L1014S, knockdown resistance east type (kdr-e) allele was detected for the first time among the mosquito samples in this study. The L1014F, knockdown resistance west type (kdr-w) allele and heteroduplex form (wild-type—mutant) were found in almost all Anopheles species examined, including An. vagus, An. aconitus, An. subpictus, An. tesselatus, An. annularis, An. flavirostris and An. sundaicus. Conclusion The presence of fully susceptible phenotypes over time, along with an increase in the frequency distribution of the L1014F/S mutations post-intervention, suggest drivers of resistance external to the study, including pyrethroid use in agriculture and long-lasting insecticidal nets (LLINs). However, this does not negate possible SR impacts that support resistance. More studies that enable the comprehension of possible SR-based drivers of resistance in mosquitoes need to be conducted.

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Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Cited by 12 publications

References 24 publications

Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Current status of insecticide resistance in malaria vectors in the Asian countries: a systematic review

Susceptibility status of Anopheles gambiae complex in NNEWI community, Anambra state

Impact of a spatial repellent intervention on Anopheles kdr insecticide resistance allele in Sumba, Indonesia

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