Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease

Seyedizade, Seyede Sara; Afshari, Khashayar; Bayat, Saba; Rahmani, Fatemeh; Momtaz, Saeideh; Rezaei, Nima; Abdolghaffari, Amir Hossein

doi:10.1007/s00005-020-00576-4

Cited by 50 publications

(34 citation statements)

References 76 publications

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“…M0/M1 cells are highly related to the deterioration of the disease. Many articles have shown that M1 cells in inflammatory bowel disease are the main cell type that releases inflammatory factors (30)(31)(32). It is known that LPS and IFN-γ can activate M1 macrophages through the nuclear factor kappa-B (NF-κB) signaling pathway, producing the proinflammatory factors IL-1β, IL-6, IL-23, TNF-α and ROS (33).…”

Section: Discussionmentioning

confidence: 99%

The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Colitis Progression

Rouzigu

Teng

et al. 2021

BioMed Research International

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Ulcerative colitis (UC) is a common disease with great variability in severity, with a high recurrence rate and heavy disease burden. In recent years, the different biological functions of competing endogenous RNA (ceRNA) networks of long noncoding RNAs (lncRNAs) and microRNAs (miRs) have aroused wide concerns, the ceRNA network of ulcerative colitis (UC) may have potential research value, and these expressed noncoding RNAs may be involved in the molecular basis of inflammation recurrence and progression. This study analyzed 490 colon samples associated with UC from 4 gene expression microarrays from the GEO database and identified gene modules by weighted correlation network analysis (WGCNA). CIBERSORT detected tissue-infiltrating leukocyte profiling by deconvolution of microarray data. LncBase and multiMIR were used to identify lncRNA-miRNA-mRNA interaction. We constructed a ceRNA network which includes 4 lncRNAs (SH3BP5-AS1, MIR4435-2HG, ENTPD1-AS1, and AC007750.1), 5 miRNAs (miR-141-3p, miR-191-5p, miR-192-5p, miR-194-5p, and miR196-5p), and 52 mRNAs. Those genes are involved in interleukin family signals, neutrophil degranulation, adaptive immunity, and cell adhesion pathways. lncRNA MIR4435-2HG is a variable in the decision tree for moderate-to-severe UC diagnostic prediction. Our work identifies potential regulated inflammation-related lncRNA-miRNA-mRNA regulatory axes. The regulatory axes are dysregulated during the deterioration of UC, suggesting that it is a risk factor for UC progression.

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Section: Discussionmentioning

confidence: 99%

The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Colitis Progression

Rouzigu

Teng

et al. 2021

BioMed Research International

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“…Chronic inflammation plays a major role in various chronic diseases, such as respiratory, cardiovascular, gastrointestinal, hepatobiliary, urogenital, neurological, skeletal, rheumatological systems, and cancer diseases [43][44][45][46][47][48]. e effect of Cynanchum paniculatum and its derivatives on [31,[49][50][51][52].…”

Section: Modulation Of Inflammation By Cynanchum Paniculatum and Its mentioning

confidence: 99%

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory‐Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

Chen

Cheng

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Cynanchum paniculatum Radix, known as Xuchangqing in Chinese, is commonly prescribed in Chinese Medicine (CM) for the treatment of various inflammatory diseases. The anti-inflammatory property of Cynanchum paniculatum can be traced from its wind-damp removing, collaterals’ obstruction relieving, and toxins counteracting effects as folk medicine in CM. This paper systematically reviewed the research advancement of the pharmacological effects of Cynanchum paniculatum among a variety of human diseases, including diseases of the respiratory, circulatory, digestive, urogenital, hematopoietic, endocrine and metabolomic, neurological, skeletal, and rheumatological systems and malignant diseases. This review aims to link the long history of clinical applications of Cynanchum paniculatum in CM with recent biomedical investigations. The major bioactive chemical compositions of Cynanchum paniculatum and their associated action mechanism unveiled by biomedical investigations as well as the present clinical applications and future perspectives are discussed. The major focuses of this review are on the diverse mechanisms of Cynanchum paniculatum and the role of its active components in inflammatory diseases.

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“…Macrophages are an important component of natural immunity that form part of the first line defence in intestinal mucosa and have been shown to play an important role in the initiation of UC 3‐6 . In humans, macrophages are classified into two subsets with seemingly different functions: M1 macrophages, also known as ‘classically activated’ macrophages, are mainly involved in biological processes that promote inflammation and inhibit tumours, whereas M2 macrophages, also known as ‘selectively activated’ macrophages, play important roles in tumour progression, parasite control and tissue repair 7 .…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the intestinal mucosal immune system plays an important role in the occurrence, progression and outcome of UC 3 and abnormal immune regulation is a key feature of its pathogenesis.Macrophages are an important component of natural immunity that form part of the first line defence in intestinal mucosa and have been shown to play an important role in the initiation of UC. [3][4][5][6] In humans, macrophages are classified into two subsets with seemingly different functions: M1 macrophages, also known as 'classically activated' macrophages, are mainly involved in biological processes that promote…”

mentioning

confidence: 99%

M1 Macrophage exosomes MiR‐21a‐5p aggravates inflammatory bowel disease through decreasing E‐cadherin and subsequent ILC2 activation

Liu

Tan

et al. 2021

J Cellular Molecular Medi

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Abnormal immune regulation is a key feature of the complex pathogenic mechanism of ulcerative colitis (UC). In particular, macrophages and group 2 innate lymphoid cells (ILC2s) are important components of natural immunity that have been shown to play important roles in the pathogenesis of UC, as well as decreased E‐cadherin expression on the colonic mucosa. However, it remains unclear how these components interact with each other. In this study, we investigated the molecular mechanisms of UC mediated by macrophage‐derived exosomes. We showed for the first time that miR‐21a‐5p expression is increased in the peritoneal exosomes of mice with dextran sulphate sodium induced enteritis and that miR‐21a‐5p expression correlates negatively with E‐cadherin expression in enterocytes. Moreover, we confirmed that miR‐21a‐5p was mainly derived from M1 macrophages and demonstrated that KLRG1, a surface inhibitory receptor on ILC2s, participated in excessive ILC2 activation in UC by promoting GATA‐3. In conclusion, our results suggest molecular targets and provide a theoretical basis for elucidating the pathogenesis of UC and improving its treatment.

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Current Status of M1 and M2 Macrophages Pathway as Drug Targets for Inflammatory Bowel Disease

Cited by 50 publications

References 76 publications

The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Colitis Progression

The Construction and Comprehensive Analysis of Inflammation-Related ceRNA Networks and Tissue-Infiltrating Immune Cells in Ulcerative Colitis Progression

Cynanchum paniculatum and Its Major Active Constituents for Inflammatory‐Related Diseases: A Review of Traditional Use, Multiple Pathway Modulations, and Clinical Applications

M1 Macrophage exosomes MiR‐21a‐5p aggravates inflammatory bowel disease through decreasing E‐cadherin and subsequent ILC2 activation

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