Current Status of Skin Substitutes

Tavis, Michael J.; Thornton, James W.; Danet, Richard; Bartlett, Robert H.

doi:10.1016/s0039-6109(16)41688-9

Cited by 65 publications

(10 citation statements)

References 41 publications

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“…Moreover there are plans to use it in the production of artificial skin [4]. Modern medical biotechnology has accepted artificial skins as a valid prospect [5]. Several properties that are advantageous for its use as a temporary skin substitute have been recognized for BioFill, a competitive product based on an Acetobacter xylinum cellulosic material [6].…”

Section: Introductionmentioning

confidence: 99%

Optimization of fermentation conditions for the production of bacterial cellulose by a newly isolated Acetobacter

Son

Heo

Kim

et al. 2001

Biotech and App Biochem

172

100

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The optimum fermentation conditions for the production of cellulose by a newly isolated Acetobacter sp. A9 were determined by shaken cultures. The strain was able to produce cellulose at 25-30 degrees C with a maximum at 30 degrees C. Cellulose production occurred at pH 4.5-7.5 with a maximum at pH 6.5. The improved medium composition was 4% (w/v) glucose, 0.1% (w/v) yeast extract, 0.7% (w/v) polypeptone and 0.8% (w/v) Na(2)HPO(4).12H(2)O. Under these culture conditions, 3.8 g/l cellulose was produced after 7 days of cultivation, although this strain produced only 2.2 g/l in the standard medium. The addition of ethanol to the improved medium enhanced cellulose production: in an improved medium containing 1.4% (v/v) ethanol, cellulose production was 15.2 g/l, which was about four times higher than that without ethanol. Addition of ethanol was found to eliminate the spontaneous mutation of Acetobacter sp. A9.

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Section: Introductionmentioning

confidence: 99%

Optimization of fermentation conditions for the production of bacterial cellulose by a newly isolated Acetobacter

Son

Heo

Kim

et al. 2001

Biotech and App Biochem

172

100

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“…Cell-laden autologous, allogeneic, and xenogeneic tissues have been used as viable grafts and transplants for heart valves (Angell et al 1979;Jamieson et al 1984), coronary arteries and peripheral vessels (Tice et al 1976;Bortolotti et al 1981), skin (Tavis et al 1978;Peters 1980), the anterior cruciate ligament (Indelicato et al 1992;Olson et al 1992), and cornea (Tsai and Tseng 1994), among other clinical applications. The obvious limitations of these graft materials include the foreign antigens present on the allogeneic and xenogeneic cell component and the associated adverse immune response, the limited number of allogeneic do-nors, the devascularized state of free autografts, and the associated morbidity of the donor site with autologous grafts.…”

mentioning

confidence: 99%

Biologic Scaffolds

Costa

Naranjo

Londoño

et al. 2017

Cold Spring Harb Perspect Med

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“…Die meisten bekannten Hautersatzmaterialien wurden von Tavis und seinen Mitarbeitern untersucht [14]. Sie kamen erwartungsgem/iB zu dem SchluB, dab der sogenannte Allograft zwar die gfinstigsten Ergebnisse zeigt, jedoch zwei wesentliche Nachteile mit sich bringt: Neben der begrenzten Verffigbarkeit stellt die AbstoBung nach einer relativ kurzen Zeit (ca.…”

Section: Materials Und Methodeunclassified

“…Dermodress ®, eine chemisch und physikalisch vorbehandelte Haut bovinen Ursprungs wird vorgestellt. Eine Anzahl verschiedenster Materialien wurde unter dieser Indikation untersucht, die meisten sind von Tavis et al vergleichend beschrieben [14]. Neben einem haemostatischen Effekt kann es gut an die Oberfl~ichenkonturen anmodelliert werden, ohne bis zum 56.…”

unclassified

Erste klinische Erfahrungen bei der Verwendung von Dermodress�, einem neuen tempor�ren biologischen Hautersatz

Walter

Sagi²,

Feuchtwanger³

et al. 1987

Langenbecks Arch Chiv

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A chemically treated bovine skin, Dermodress, is presented as a long-term skin substitute. Dermodress was applied over denuded surfaces of debrided deep burns and was kept in place up to 56 days. At this time it was totally replaced by autograft, so we have no idea yet of how much longer it could have remained. It adheres to all contours of the debrided area, has hemostatic effect, and does not present any sign of infection or rejection. Dermodress can be removed in stages according to the availability of autografts, which may be applied immediately, since the exposed areas are clean and suitable for immediate grafting. Our clinical experience shows that Dermodress has most of the required properties of a long-term temporary skin substitute.

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Current Status of Skin Substitutes

Cited by 65 publications

References 41 publications

Optimization of fermentation conditions for the production of bacterial cellulose by a newly isolated Acetobacter

Optimization of fermentation conditions for the production of bacterial cellulose by a newly isolated Acetobacter

Biologic Scaffolds

Erste klinische Erfahrungen bei der Verwendung von Dermodress�, einem neuen tempor�ren biologischen Hautersatz

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