Current strategies for drug delivery to the inner ear

PURPOSE:To evaluate the tissue response of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant. METHODS:A total of 20 male guinea pigs were divided into 2 groups. After paracentesis in both ears, a biodegradable polymer of poly lactic-co-glycolic acid was implanted in only one middle ear. Histological analysis using neutrophil exudate and vascular neoformation (acute inflammation) and fibroblast proliferation and mononuclear inflammatory cells (chronic inflammation) as parameters was performed after 10 and 30 days of survival (groups 1 and 2, respectively). RESULTS:Four ears in group 1 and 7 in group 2 had an increase of neutrophil exudate. Vascular neoformation occurred in ears with or without the implant, in both groups. Fibroblast proliferation and mononuclear inflammatory cells (lymphocytes and macrophages) increased in ears with implant in group 2. CONCLUSION:The tissue response by histological analysis of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant, showed no statistically significant difference between ears with or without the implant.

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“…In the past decade, new biomaterials and drug delivery technologies have been developed for inner ear delivery 2,5 .…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, there is an increasing interest in the treatment of human inner ear disorders by local drug delivery to the inner ear for the dual purposes of increasing efficacy and decreasing side effects [2][3][4][5] .…”

Section: Introductionmentioning

confidence: 99%

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

et al. 2014

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“…Гемато-лабиринтный барьер (ГЛБ), формируемый эндотелием капилляров сосудистой полоски, эволюционно выполня-ет функцию поддержания уникального микрогомеостаза жидкостных сред улитки, функционируя как высокосе-лективный физический и биохимический барьер [20]. Эти же его свойства не позволяют ксенобиотикам (лекарственным веществам) проницать во внутрикохле-арные структуры и оказывать ототропные эффекты.…”

Section: Introductionunclassified

Пористый Кремний Как Наноматериал Для Дисперсных Транспортных Систем Направленной Лекарственной Доставки Ко Внутреннему Уху

Спивак¹,

Белорус²,

Паневин³

et al. 2018

Журнал Технической Физики

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“…The RWM acts like a semipermeable membranous interfaces (Duan & Chen, 2009;Liu et al, 2013;El Kechai et al, 2015) and low-molecular weight substances such as various kinds of aminoglycoside antibiotics and corticosteroids are rapidly transported through it (Juhn et al, 1989). Passive diffusion was generally considered to be the main mechanism by which drug migrates from the middle ear cavity to the inner ear through the triple-layered RWM (Salt & Plontke, 2005).…”

Section: Analyzing Local Trans-rwm Drug Transport Profilesmentioning

confidence: 99%

“…The blood-labyrinth barrier (BLB), which is physiologically similar to the blood-brain barrier (BBB), limits the concentration and size of molecules that can be transported from the blood circulation to the inner ear cell (McCall et al, 2010;Liu et al, 2013). There is an increasing interest in the use of topical applications for the treatment of inner ear disorders.…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling for local trans-round window membrane drug transport in the inner ear

Zhang

Wen

et al. 2016

Drug Delivery

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(2016) Mathematical modeling for local trans-round window membrane drug transport in the inner ear, Drug Delivery, 23:8, 3082-3087, DOI: 10.3109/10717544.2016 AbstractThe structure and composition of the round window membrane (RWM) make it a particularly effective pathway for drug delivery to the inner ear. Therefore, predicting the efficiency of RWM transport would provide useful information for enhancing local application. In the present study, a mathematical model was established to achieve this goal. A series of drugs with different physicochemical properties were introduced in the inner ear cavity of guinea pigs via RWM by intratympanic application. The perilymphatic drug concentration (C) data were used to calculate the permeability coefficient (K p ) of different drugs diffusing through the RWM. The experimental data were fitted using the Matlab software to set up the numerical model based on Fick's diffusion law and the single-compartment model following extravascular administration, which facilitated the prediction of the permeation profiles of different drugs while trans-RWM. In summary, this mathematical model is a contribution toward developing potentially useful RWM administration simulating tools.

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Current strategies for drug delivery to the inner ear

Cited by 71 publications

References 103 publications

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Tissue response evaluation of the mucosa of the tympanic cavity of guinea pigs, when receiving biodegradable implant

Пористый Кремний Как Наноматериал Для Дисперсных Транспортных Систем Направленной Лекарственной Доставки Ко Внутреннему Уху

Mathematical modeling for local trans-round window membrane drug transport in the inner ear

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