Current treatment of lymphoma in pregnancy

Supportive medication in cancer during pregnancy

“…There were no significant differences in spontaneous abortion and preterm delivery, whereas adverse events in the neonates were similar in both groups [8]. Similar conclusions were drawn from studies on pregnant women with breast cancer or lymphoma and other malignancies [9][10][11]. In an attempt to validate the beneficial role of GCSF for the treatment of unexplained recurrent miscarriage proposed by a previous study, a randomized, double-blind, placebo controlled clinical trial involving 150 women with a history of unexplained recurrent pregnancy loss was conducted.…”

Unusual Presentation of Hodgkin’s Lymphoma in Pregnancy: A Case Report and Systematic Review of Literature

“…All included studies were case reports and original articles. Ten studies diagnosed pregnant women with nodular sclerosis HL [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ], Five described management of pregnant women diagnosed with lymphocyte-rich HL [ 14 , 15 , 16 , 17 , 18 ], and one study described management of pregnant patient with stage-4 classical HL [ 19 ]. Ten of the included studies treated all pregnant patients diagnosed with HL with standard cycle of ABVD with no report of maternal or fetal complications from the chemotherapy regimen [ 5 , 6 , 7 , 8 , 9 , 10 , 12 , 17 , 19 ], but with the exception of three studies; in which one of the three studies reported that ABVD chemo therapy resulted in preterm contraction and rupture of membrane [ 5 ], second study described the addition of 25 mg/m 2 doxorubicin per cycle of ABVD which resulted in left cardiac dysfunction with high levels of troponin in the newborn on day 4 of life which later resolved on month one of life [ 16 ], and the third study reported an adverse effect with ABVD chemotherapy resulting in preterm birth, and the need for immediate post-partum blood transfusion with subsequent development of venous thromboembolism in the mother [ 11 ].…”

“…For the treatment of HL with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone), five studies [ 4 , 9 , 12 , 14 , 15 ] reported no complication with the chemo regimen in pregnant patients and their fetuses. It was observed that R-CHOP was commonly used for the chemotherapeutic regimen in pregnant patients diagnosed with lymphocyte-rich HL while ABVD regimen was more popular for the treatment of nodular sclerosing HL.…”

Effect of Intra Uterine Granulocyte Colony Stimulating Factor vs. Human Chorionic Gonadotropin at Ovum Pick Up Day on Pregnancy Rate in IVF/ICSI Cases With Recurrent Implantation Failure

“…In regards to the safety of G-CSF on the developing embryo, several studies have looked into the effects of G-CSF in pregnant patients with cancer and found no significant difference in teratogenicity between patients prescribed G-CSF and individuals not prescribed G-CSF, thereby indicating that G-CSF had no teratogenic effect on the developing fetus (Zeidler et al, 2014;Boxer et al, 2015;Gurevich-Shapiro & Avivi, 2019;Cardonick et al, 2012).…”