Current trends and perspectives of bioactive peptides

Abstract

The remarkable growth of therapeutic peptide development in the past decade has led to a large number of market approvals and the market value is expected to hit $25 billion by 2018. This significant market increase is driven by the increasing incidences of metabolic and cardiovascular diseases and technological advancements in peptide synthesis. For this reason, the search for bioactive peptides has also increased exponentially. Many bioactive peptides from food and nonfood sources have shown positive health effects yet, obstacles such as the need to implement efficient and cost-effective strategies for industrial scale production, good manufacturing practices as well as well-designed clinical trials to provide robust evidence for supporting health claims continue to exist. Several other factors such as the possibility of allergenicity, toxicity and the stability of biological functions of the peptides during gastrointestinal digestion would need to be addressed.

Synthetic molecular evolution of hybrid cell penetrating peptides

“…Interest in lipidic and peptidic delivery strategies are expected to grow as efficiencies improve and costs decrease. Similarly, the peptide therapeutics market was valued at $17.5B in 2015 and is expected to increase at a compound annual growth rate of ~10% through 2025 as researchers and drug companies look to bypass impediments that arise with small-molecule therapeutics from off-target interactions, low response rates, and drug resistance 2 , 38 . While antisense oligomers have not yet reached the therapeutic marketplace, the potential for a substantial market is clear 3 , 39 .…”

Identification and Molecular Docking Study of a Novel Angiotensin-I Converting Enzyme Inhibitory Peptide Derived from Enzymatic Hydrolysates of Cyclina sinensis

“…For bioactive peptides to remain active after ingestion, they must be resistant to the gastrointestinal tract conditions [ 25 ]. In vitro methods offer a simpler way of investigating this issue than expensive, cumbersome animal experiments or in vivo tests, and yield detailed information.…”

Efectos fisiológicos de los péptidos bioactivos derivados de las proteínas del lactosuero en la salud: Una revisión

“…Sin embargo, se ha demostrado que la medicación a largo plazo puede tener efectos secundarios adversos 10 . Por lo que es importante explorar alternativas innovadoras que permitan mitigar este padecimiento 14 .…”