Current Update on Biomarkers for Detection of Cancer: Comprehensive Analysis

Abstract

Early and effective diagnosis of cancer is decisive for its proper management. In this context biomarker-based cancer diagnosis is budding as one of the promising ways for early detection, disease progression monitoring, and effective cancer therapy. Integration of Biosensing devices with different metallic/nonmetallic nanoparticles offers amplification and multiplexing capabilities for simultaneous detection of cancer biomarkers (CB’s). This study provides a comprehensive analysis of the most recent designs and fabrication methodologies designed for developing electrochemical biosensors (EB) for early detection of cancers. The role of biomarkers in cancer therapeutics is also discussed.

Metal–organic framework-interfaced ELISA probe enables ultrasensitive detection of extracellular vesicle biomarkers

“…1 These low-abundance proteins can serve as biomarkers for diseases and can predict the occurrence of any disease. 2 Therefore, significant efforts have been continuously invested to develop a variety of technologies for ultrasensitive protein detection, including nanostructures and nanoparticle-based bar-codes, 3 electrochemical biosensors, 1 single molecule detection, 4 immuno-PCR, 5 microfluidic immunoassay, 6 nanoparticle-based electrochemiluminescence biosensors, 7,8 and so on. Immunoassays, including ELISA (enzyme-linked immunosorbent assay), provide powerful tools for the sensitive detection and quantification of soluble substances, 9,10 a subject that has attracted significant interest.…”

Development of Ti3C2Tx‐based novel immunosensor for cancer biomarker detection

“…Recently, biosensors have been considered the most accurate, fast, and sensitive analytical method for biomarker detection. 11 They identify cancer biomarkers by employing biorecognition elements like antibodies, DNA, RNA, etc., which transform biological signals into observable electrical signals. 12 Though numerous varieties of biosensors have been published for the identification of biomarkers.…”

Microfluidic Technology, Artificial Intelligence, and Biosensors As Advanced Technologies in Cancer Screening: A Review Article

“…Screening is a technique for a secondary level of prevention that aims to decrease cancer mortality while maintaining the incident rate constant. Given a significant lag time in the malignant transition, screening presents an opportunity to detect premalignant lesions, engage in early intervention in the carcinogenic process, and delay the onset of cancer [ 2 ].…”