Current Updates On the In vivo Assessment of Zinc Oxide Nanoparticles Toxicity Using Animal Models

Chong, Ce Lynn; Fang, Chee‐Mun; Pung, Swee‐Yong; Ong, Chin Eng; Pung, Yuh Fen; Kong, Cin; Pan, Yan

doi:10.1007/s12668-021-00845-2

Cited by 37 publications

(14 citation statements)

References 150 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the heatmap and clustering analysis in the zebrafish model are also consistent with in vivo reports in animal models where ZnO, CuO and CeO 2 are consistently found to be toxic. [98][99][100][101][102] Moreover, the benefits of the zebrafish over the in vitro model are nicely illustrated with microscopic crystalline SiO 2 (MIN-U-SIL® 5), which was inconsistently ranked between different tiersnegative in acellular FRAS, mild to moderate effects in vitro, Environmental Science: Nano Paper and more severe effects on metabolic activity and DNA damage in vivo. Crystalline SiO 2 did not induce oxidative stress in the FRAS assay and showed low to moderate toxicity in THP-1 cells in vitro (Fig.…”

Section: Environmental Science: Nano Papermentioning

confidence: 99%

Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model

Kaur

Sohal

Singh

et al. 2022

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

Section: Environmental Science: Nano Papermentioning

confidence: 99%

Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model

Kaur

Sohal

Singh

et al. 2022

Environ. Sci.: Nano

View full text Add to dashboard Cite

show abstract

“…On the contrary, Reactive oxygen species production and consequent oxidative stress is the most well-known exact cause of ZnO-NPs toxicities. Oxidative stress was caused by a series of events; including the formation of ROS on the particle's surface, the breakdown and release of Zn 2+ ions, and ZnO-NP's physical contact with biological molecules (Saliani et al, 2016;Chong et al, 2021).…”

Section: B)mentioning

confidence: 99%

Renal Toxicity of Oral Subacute Exposure to Zinc Oxide Nanoparticles in Adult Male Albino Rats

Said

Mohamed

Aref

et al. 2022

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

View full text Add to dashboard Cite

Background: One of the most essential and commonly utilized nanoparticles is zinc oxide nanoparticles (ZnO-NPs). They are widely used in commercial items such as sunscreens and daily-care products, as well as in the food industry as a food additive and in food packaging because of their antibacterial and fungicidal properties. Aim: The study aimed to evaluate the subacute toxic effects of different doses of ZnO-NPs on the kidneys of adult male albino rats. Methods: Forty adult male albino rats were divided into four groups (10 rats per group); Group I served as the control (Negative control), Group II ZnO-NPs treated group (10mg/kg/day), Group III ZnO-NPs treated group (100mg/kg/day) and Group IV ZnO-NPs treated group (200mg/kg/day) for 28 days orally. The levels of serum urea, creatinine, uric acid, and zinc were estimated. Furthermore, oxidative stress markers in kidney tissue, including malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) were estimated. Histopathological examination of the kidney tissues by light microscope was performed. Results: Oral ZnO-NPs induced a significant increase in serum creatinine, urea, uric acid, and zinc in a dose-dependent manner as the higher the dose the more significant toxicity. Zinc oxide nanoparticles induced a significant elevation of MDA and a significant decrease in the antioxidant enzymes SOD and GPx in kidney tissue also in a dose-dependent manner as toxicity is more evident in the high doses. Also, significant histopathological changes were detected in the kidney tissues. Conclusion: It can be concluded that subacute oral administration of ZnO-NPs induces nephrotoxic effects in a dose-dependent manner. The present study recommends that full attention must be given to evaluating the safety and toxicological issues of nanoparticles on the tissue, cells, and macromolecule of the human body.

show abstract

“…(43, 44) Pulmonary toxicity: Since inhalation is the major route of ZnO-NPs' exposure in the workplace, the concern about pulmonary toxicity of ZnO-NPs is growing. (45) ZnO-NPs could induce cytotoxicity in human lung epithelial cell by promoting oxidative stress causing damage to DNA and apoptosis. (46) Cho et al (47) detected that inhalation of ZnO-NPs induced inflammation and fibrosis in the tracheobronchial and alveolar tissues.…”

Section: Toxicological Hazards Of Zinc Oxide Nanoparticlesmentioning

confidence: 99%

Biomedical Applications and Toxicological Aspects of Zinc Oxide Nanoparticles: A Review Article

Aref

Said²,

Ahmed³

et al. 2022

Sohag Medical Journal

View full text Add to dashboard Cite

Nanotechnology is one of the fastest-growing and most promising modern technologies. It deals with the manufacturing and use of nanoparticles. Nanoparticles are generally known as small-sized particles possessing a size range of 1 to 100 nm. Due to their distinctive physicochemical and mechanical characteristics, they are utilized in various fields like agriculture, material science, food industry, medical, diagnostic, and cosmetic applications. One of the nanoparticles that is most frequently used nowadays is Zinc oxide nanoparticles. They have been explored for numerous biomedical applications, such as drug delivery, anticancer, antibacterial, antidiabetic, and bioimaging. Researchers expect that usage of Zinc oxide nanoparticles will expand so; the human body's exposure to them will increase. Zinc oxide .nanoparticles released into the environment could lead to adverse human and animal health effects. Recent studies concluded that Zinc oxide nanoparticles could cross some blood vital organs barriers and cell membranes, generate free radicals, and exhibit oxidative stress, cytotoxicity, and genotoxicity. Therefore, great attention must be taken to assess the toxicological aspects of nanoparticles.

show abstract

Current Updates On the In vivo Assessment of Zinc Oxide Nanoparticles Toxicity Using Animal Models

Cited by 37 publications

References 150 publications

Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model

Toxicity screening and ranking of diverse engineered nanomaterials using established hierarchical testing approaches with a complementary in vivo zebrafish model

Renal Toxicity of Oral Subacute Exposure to Zinc Oxide Nanoparticles in Adult Male Albino Rats

Biomedical Applications and Toxicological Aspects of Zinc Oxide Nanoparticles: A Review Article

Contact Info

Product

Resources

About