Current use of skin and wound cleansers and antiseptics

Laufman, Harold

doi:10.1016/0002-9610(89)90570-9

Cited by 41 publications

(27 citation statements)

References 34 publications

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“…The extent of its antiseptic, germicidal, astringent and caustic or escharotic activity depends on the concentration used, as well as the period of time during which the compound is allowed to act [1]. At high concentrations (40%), silver compounds are cauterizing agents, at intermediate concentrations (10%) they are bactericidal and at lower concentrations they are only bacteriostatic [2]. Weak solutions have had a variety of uses: 0.5% solutions have been applied to second-and third-degree burns and 1% silver nitrate solution is still used as eyedrops at birth to prevent gonococcal ophthalmia neonatorum despite the European Community Directive 83/ 467/EEC, Appendix 6, Part II (B), which classifies silver nitrate as a substance presenting a risk of serious damage to eyes [3].…”

Section: Introductionmentioning

confidence: 99%

Silver Nitrate: Antimicrobial Activity Related to Cytotoxicity in Cultured Human Fibroblasts

Hidalgo

Bartolomé²,

Barroso³

et al. 1998

Skin Pharmacol Physiol

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The aims of this study were to ascertain whether silver nitrate (AgNO₃) concentrations below those used in clinical practice inhibit bacterial growth, and in parallel study the cytotoxic effects on human fibroblasts. The cytoprotective effects of fetal calf serum (FCS) were also evaluated. The cytotoxic effects of eight different silver nitrate concentrations were determined by assessing mitochondrial activity of viable cells capable of cleaving tetrazolium salts. Antimicrobial activity of AgNO₃, range: 7–550 × 10^–5%, was tested against Staphylococcus aureus, Citrobacter freundii, and Pseudomonas aeruginosa. Silver nitrate concentrations exerting antimicrobial effects were: S. aureus, >70 × 10^–5%; P. aeruginosa, ≥270 × 10^–5%, and C. freundii, ≥550 × 10^–5%. With 2% FCS, the lowest AgNO₃ concentration studied (7 × 10^–5%) showed cytotoxic effects (cell survival 71 ± 19%) at only 2 h of incubation. Under these conditions AgNO₃ cytotoxicity was time- and concentration-dependent in all exposure periods. Cytotoxicity was greatly enhanced causing 76% fibroblast growth inhibition at concenctrations of 14 × 10^–5% and contact time of 2 h. The AgNO₃ concentration of 7 × 10^–5% was also cytotoxic with 5% FCS in the media compared with controls, although cell survival was higher than with 2% FCS. The cytoprotective action of FCS was clearly shown at the concentration of 10% at which AgNO₃ cytotoxicity of 7 × 10^–5% to 28 × 10^–5% was partially or completely inhibited. Our results show that AgNO₃ at concentrations 100–700 times more diluted than that normally used in clinical practice retained effective inhibitory activity against some of the above-mentioned microorganisms. However, even these concentrations are cytotoxic for cultured fibroblasts. Thus, silver nitrate concentrations up to 100 times more diluted can be used, since they possess bacterial growth-inhibiting power, are less cytotoxic and therefore favour wound healing.

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Section: Introductionmentioning

confidence: 99%

Silver Nitrate: Antimicrobial Activity Related to Cytotoxicity in Cultured Human Fibroblasts

Hidalgo

Bartolomé²,

Barroso³

et al. 1998

Skin Pharmacol Physiol

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“…As a generalization, those who have also undertaken a reasonable review of the literature [11, 25, 36] have not only scored higher overall, but also support the use of PVP-I. This is primarily due to the fact they publicly refute the evidence of experimental studies that were undertaken in vitroor in vivoon animals only.…”

Section: Discussionmentioning

confidence: 92%

What Is the Evidence for Tissue Regeneration Impairment when Using a Formulation of PVP-I Antiseptic on Open Wounds?

Banwell¹

2006

Dermatology

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Wound care and the use of antiseptics has long been the subject of much debate within the health professional’s literature. This study was undertaken to determine the range of literature available on povidone-iodine (PVP-I) antiseptic use and the evidence supporting the outcomes reported. A range of articles was collected and divided into subgroups based on hierarchy of evidence and the five evidence dimensions [1]. Using the READER^® scoring tool, articles were evaluated and given a numerical award between 4 and 25 as a determinant of their quality in method, statistical analysis and outcome measures, with those scoring 12.5 or higher (from a possible 25) deemed as offering a satisfactory level of evidence. Statistical analysis on the results prior to applying the READER scoring tool found that overall 49% of articles did not support PVP-I use. However, this situation changed when the quality of evidence was limited to articles scoring >12.5. The higher-scored articles showed a 71% support for the continued use of PVP-I. The outcome of this study shows that there is reason for further debate over the use of PVP-I.

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“…Apesar do espectro antimicrobiano (FOSSUM et al, 1997;CANDIDO, 2001;RODRIGUES et al, 2001) e do efeito residual do iodo polivinilpirrolidona (LAUFMAN, 1989;SWAIM e GEIGER, 1991;BOSQUEIRO et al, 1999;CANDIDO, 2001;RODRIGUES et al, 2001), a reparação das lesões submetidas à aplicação deste anti-séptico foi mais lenta quando comparada às feridas tratadas com ácidos graxos essenciais, lecitina de soja e vitaminas A e E. Este fato pode ser atribuído à toxicidade do iodóforo para fibroblastos e à interferência na quimiotaxia dos polimorfonucleares, descritas por TVEDTEN e TILL (1985), ZAMORA (1986), SANCHEZ et al (1988) e CANDIDO (2001), apesar de não terem sido detectados DE NARDI, A.B. et al sinais compatíveis com alterações colaterais sistêmicas (ZAMORA, 1986;OSUNA et al, 1990).…”

Section: Discussionunclassified

“…O iodóforo é um complexo de iodo fracamente ligado à polivinilpirrolidona, molécula carreadora que aumenta a solubilidade do iodo, além de gradativamente permitir sua liberação, conferindo-lhe poder residual. Este efeito residual impede o crescimento bacteriano na pele e é estimado entre 6 a 8 horas (LAUFMAN, 1989;SWAIN e GEIGER, 1991;BOSQUEIRO et al, 1999;RODRIGUES et al, 2001).…”

Section: Revisão De Literaturaunclassified

CICATRIZAÇÃO SECUNDÁRIA EM FERIDAS DERMOEPIDÉRMICAS TRATADAS COM ÁCIDOS GRAXOS ESSENCIAIS, VITAMINAS A e E, LECITINA DE SOJA E IODO POLIVINILPIRROLIDONA EM CÃES

Nardi¹,

Rodaski²,

Sousa³

et al. 2004

AVS

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RESUMO -Com o objetivo de avaliar os efeitos da solução contendo ácidos graxos essenciais, lecitina de soja e vitaminas A e E sobre a cicatrização secundária de feridas dermoepidérmicas, observou-se a evolução da reparação tecidual em nove cães machos, SRD, com idade variando entre três e cinco anos e peso de 12 kg em média. Para isto, em cada paciente foram produzidos dois defeitos de pele, medindo 6cm de altura (sentido dorsoventral) x 4cm de largura (sentido craniocaudal) em ambas as faces laterais do tórax e do abdome, sendo que nas lesões do lado esquerdo procedeu-se a avaliação física e mensuração diária, enquanto que nas feridas do lado direito, realizou-se biópsia incisional a cada dois dias. Nas lesões abdominais esquerdas, tratadas com ácidos graxos e curativos úmidos com solução fisiológica 0,9%, tanto macro como microscopicamente, observou-se inflamação aguda durante os três primeiros dias, sendo esta seguida pelos eventos de granulação, contração e reepitelização completa até o 25º dia. Nas feridas torácicas esquerdas, expostas ao iodo polivinilpirrolidona e curativos úmidos, constatouse a predominância dos eventos inflamatórios agudos por sete dias, seguida dos fenômenos proliferativos, de contração e completa reepitelização até o 31º dia pós cirúrgico. A ausência de sinais compatíveis com toxicidade sistêmica e a mais rápida cicatrização das lesões tratadas com ácidos graxos, permitem a indicação desta solução para o tratamento de feridas abertas dermoepidérmicas, em cães.Palavras chaves: Cicatrização, ácidos graxos essenciais, lecitina de soja, iodo polivinilpirrolidona, cão.ABSTRACT -The effects of a solution containing essential fatty acids, soy lecithin and vitamins A and E in the healing of canine second intention dermoepidermal wounds were evaluated. In order to observe evolution of the tissue repair. Nine male, mixed breed dogs, with age varying between three and five years and average weight of 12 kg, were used in the experiment. Skin wounds were surgically performed in each dog. Two defects (6 x 4 cm) were performed in both thoracic and abdominal lateral faces of the animals. Daily physical evaluation and measurement were analyzed in the lesions situated on the left side, while incisional biopsy every other day was performed in the right side lesions. The left abdominal lesions, treated with fatty acids and humid curatives with physiologic solution 0.9 %, showed macro and microscopic changes such as acute inflammation during the firs three days. After this period and until the 25 th day, granulation tissue followed by contraction events and total reepitelization were observed. The left thoracic lesions, treated with povidone-iodine and humid curatives, showed predominance of acute inflammatory

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Current use of skin and wound cleansers and antiseptics

Cited by 41 publications

References 34 publications

Silver Nitrate: Antimicrobial Activity Related to Cytotoxicity in Cultured Human Fibroblasts

Silver Nitrate: Antimicrobial Activity Related to Cytotoxicity in Cultured Human Fibroblasts

What Is the Evidence for Tissue Regeneration Impairment when Using a Formulation of PVP-I Antiseptic on Open Wounds?

CICATRIZAÇÃO SECUNDÁRIA EM FERIDAS DERMOEPIDÉRMICAS TRATADAS COM ÁCIDOS GRAXOS ESSENCIAIS, VITAMINAS A e E, LECITINA DE SOJA E IODO POLIVINILPIRROLIDONA EM CÃES

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