Current Views on Blood Coagulation and Hæmorrhagic Disorders

Fantl, P

doi:10.1111/imj.1961.10.2.150

Cited by 5 publications

(2 citation statements)

References 94 publications

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“…In a Finnish survey (Ikkala, 1960), the corresponding incidence was I: 17,000 males. Fantl (1961) considered that the frequency of hcemophilia alone in Australia was I : 10,000 males, this comparing with a ratio of I : 7,500 from the present cases.…”

Section: Discussionsupporting

confidence: 70%

Hereditary Bleeding Disorders in Western Australia

1964

Australasian Annals of Medicine

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Summary The clinical and laboratory findings are reviewed in 147 cases of hereditary bleeding disorders investigated in the years 1956 to 1963. There was an unexpectedly large number of hæmophiliacs (55) in the series, many of whom were very mildly affected. The importance of mild hæmophilia as a cause of unexpected surgical bleeding is noted. The findings in patients with von Willebrand's syndrome were very variable, and about a third had a formal bleeding time when first investigated. The difficulty in diagnosis and distinction from mild hæmophilia is discussed. Menorrhagia was found to be a very frequent presenting symptom in females with this condition. A family affected by hereditary thrombocytopenia is described. This was considered to be a variant of the von Willebrand syndrome. The Hicks‐Pitney test was evaluated and found to be reliable as a screening procedure in patients with less than 30% antihæmophilic globulin.

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Section: Discussionsupporting

confidence: 70%

Hereditary Bleeding Disorders in Western Australia

1964

Australasian Annals of Medicine

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“…Evidence of thromboembolic disease in reptiles is scant in the literature. There have been few studies on reptile hemostasis, with some species exhibiting a low concentration of intrinsic clotting factors (Didisheim et al ., 1959; Fantl, 1961; Lewis, 1972), and others having higher amounts of anticoagulant or antithrombin activity (Hackett and Hann, 1967; Nahas et al ., 1973) resulting in the theory that the speed of reptilian coagulation is incredibly slow even in health. In comparison, slower coagulation in mammals would typically predispose animals to an increased risk of thromboembolic events (Good and Manning, 2003).…”

Section: Introductionmentioning

confidence: 99%

Novel Imaging Modalities for Antemortem Diagnosis of a Suspected Jugular Thrombus in a Bearded Dragon (Pogona vitticeps)

Galej,

Robertson,

Hsieh

2023

Journal of Herpetological Medicine and Surgery

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A 5-year-old male central bearded dragon (Pogona vitticeps) presented with a three-day history of left forelimb lameness, minimal muscle tone, and absent pain sensation distal to the mid-humerus. Computed tomography (CT) revealed thickened and hypoattenuating soft tissues adjacent to the left scapulohumeral and left neck regions with no abnormal contrast enhancement. The suspected left external jugular vein in this region was ill-defined and small, with filling defects, consistent with the appearance of a venous thrombus. Focal ultrasound of the left side of the neck confirmed a thrombus in this location, just cranial to a jugular venous valve. The patient was treated with supportive care and started on clopidogrel as an antithrombotic treatment. Clinical improvement was minimal following this visit and the patient presented again five months later after declining significantly. On follow-up imaging at this visit, a suspected cardiac mass was seen on echocardiography. A fine-needle aspirate of the mass at that time was suspicious for a sarcoma, however the sample was non-diagnostic. The previously identified thrombus could not be detected on ultrasonography at this visit. The owner ultimately decided to pursue hospice care at home and no additional imaging or further workup was performed. This is the first report in reptiles describing a venous thrombus using diagnostic imaging. Given the reported occurrence of aneurysms and thrombi in bearded dragons in clinical practice, this case demonstrates the use of an important tool for diagnosis of these conditions.

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Bibliography

MAUPIN

1969

Blood Platelets in Man and Animals

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Current Views on Blood Coagulation and Hæmorrhagic Disorders

Cited by 5 publications

References 94 publications

Hereditary Bleeding Disorders in Western Australia

Hereditary Bleeding Disorders in Western Australia

Novel Imaging Modalities for Antemortem Diagnosis of a Suspected Jugular Thrombus in a Bearded Dragon (Pogona vitticeps)

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