Curvularides A–E: Antifungal Hybrid Peptide–Polyketides from the Endophytic Fungus <i>Curvularia geniculata</i>

Chomcheon, Porntep; Wiyakrutta, Suthep; Aree, Thammarat; Sriubolmas, Nongluksna; Ngamrojanavanich, Nattaya; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat

doi:10.1002/chem.201000652

Cited by 57 publications

(60 citation statements)

References 26 publications

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“…According to Chomcheon (2010), 5 new hybrid peptide-polyketides [i.e., curvularides A-E (1-5)] were isolated from the endophytic fungus Curvularia geniculata, which was obtained from the limbs of Catunaregam tomentosa.…”

Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Fungal endophytes live in the inner tissues of Clerodendrum inerme and may be significant resources for new chemicals in drug discovery. A total of 242 endophytic fungi were recovered from 602 sample segments of C. inerme; 66 were purified. The 66 fungi belonging to 16 taxa and 11 genera (Alternaria, Nigrospora, Bartalinia, Pestalotiopsis, Fusarium, Mycoleptodiscus, Trichoderma, Phomopsis, Diaporthe, Lasiodiplodia, and Curvularia) were identified by morphological characteristics and fungal internal transcribed spacer sequences. The most abundant genera were Alternaria and Lasiodiplodia. Some of the endophytes exhibited tissue specificity. The colonization frequencies of endophytes in the stems were evidently higher than those in the roots and leaves. The crude ethyl acetate extracts were tested against 6 endophytes isolated from C. inerme. Three of 10 (33.3%) endophytes, which were identified as Phomopsis sp, Curvularia sp, and Mycoleptodiscus sp, displayed distinct antifungal activity against ≥3 tested fungi. To our knowledge, this is the first report of an endophytic community associated with C. inerme in China and its antifungal activity in vitro.

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Section: Discussionmentioning

confidence: 99%

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Gong¹,

Xh²,

Yq³

et al. 2015

Genet. Mol. Res.

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“…A plethora of natural products especially diverse novel peptides have been discovered from endophytic microorganisms (Seto et al 2007;Davis et al 2008;Chomcheon et al 2010;Koulman et al 2012). Recent examples include epichlicin (Seto et al 2007), a novel cyclic peptide isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.), and trichodermamide C (Davis et al 2008), a new dipeptide discovered from the malt extract broth of an endophytic fungus Eupenicillium sp.…”

Section: Identification Of a Novel Pentapeptide From Endophytic Fungimentioning

confidence: 99%

Endophytes in the plant Huperzia serrata: fungal diversity and discovery of a new pentapeptide

et al. 2014

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Endophytic fungi are an underexploited resource of natural products and have a capacity to produce diverse classes of plant-derived secondary metabolites. Here, we investigated the diversity of endophytic fungi from Huperzia serrata and the potential for discovering novel fungal natural products. One hundred and fifty-five endophytic fungi isolates obtained from H. serrata, belonging to four classes Dothideomycetes (47.3 %), Sordariomycetes (36.8 %), Eurotiomycetes (10.6 %) and an undefined class (5.3 %, Mucoraceae), were grouped into nine genera based on morphological and molecular identification. Colletotrichum, Cladosporium, Sordariomycetes and Guignardia were the dominant genera, whereas the remaining genera were infrequent groups. To our knowledge, the fungal genera Mucor and Neurospora were first reported in Huperzia plant. Among these endophytic fungi isolates, strain B14, belonging to Penicillium oxalicum, gave a gray precipitate with Dragendorff's reagent. A new pentapeptide was isolated from the culture of strain B14, and its chemical structure was elucidated on the basis of spectroscopic data from (1)H NMR, (13)C NMR and ESI-MS/MS. Taken together, H. serrata has a significant diversity of endophytic fungi that could be a rich resource for the discovery of new natural products.

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“…Secondary metabolites like Curvularides, cochlioquinones, anthraquinones, helminthosporol, helminthosporal, pre -helminthosporol and many other related metabo-lites have been reported from Cochliobolus strains. These compounds may have important pharmacological potentials, such as antifungal, anti-oxidant, antimicrobial properties (Chomcheon et al, 2010). The whole plant of A. lanata was used for the treatment of hepatitis, anticalculus, diuretic, demulcent, anthelmintic and antidiarrheal (Shoba and Mythili, 2017).…”

Section: Isolation Of Isosativenetriol From Endophytic Fungus Cochliomentioning

confidence: 99%

Isolation of isosativenetriol from endophytic fungus Cochliobolus spp. of Aerva lanata

Shoba

Sasikumar

Sathiavelu

2018

Bangladesh J Pharmacol

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Curvularides A–E: Antifungal Hybrid Peptide–Polyketides from the Endophytic Fungus Curvularia geniculata

Cited by 57 publications

References 26 publications

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

A cultured endophyte community is associated with the plant Clerodendrum inerme and antifungal activity

Endophytes in the plant Huperzia serrata: fungal diversity and discovery of a new pentapeptide

Isolation of isosativenetriol from endophytic fungus Cochliobolus spp. of Aerva lanata

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