Cushing's syndrome associated with corticogenic hypothyroidism: A case study.

Inada, Mitsuo; Kurata, Shunichiro; Nishikawa, Mitsushige; Oishi, Mariko; Mashio, Yasuo; Tanaka, Kiyoshi; Ishii, Hitoshi; Naito, Koichi; Imura, Hiroo

doi:10.1507/endocrj1954.28.225

Cited by 8 publications

(2 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some explanation for the discrepancy between these negative findings and the accepted inhibi¬ tory effects of high pharmacological doses of glu¬ cocorticoids on TSH may be provided by the heterogenous results reported in patients with Cush¬ ing's disease (2,12,(18)(19)(20)(21)(22)(23). The individual variation in our study reflects this considerable variation in the effects on basal or stimulated TSH secretion in Cushing's syndrome.…”

Section: Tablezcontrasting

confidence: 68%

The role of glucocorticoids in the regulation of thyrotropin

Brabant

Schuermeyer

et al. 1989

Acta Endocrinologica

View full text Add to dashboard Cite

Abstract. The potentially inhibitory action of endogenous or exogenous synthetic glucocorticoids on TSH secretion was investigated. Pulsatile and circadian TSH and cortisol rhythms were measured in healthy subjects (12 rhythms), but no correlation between the hormones could be detected. Acute stimulation of endogenous cortisol secretion by CRH tests (1 μg/kg of ovine CRH) at 20.00 h in 9 healthy volunteers did not significantly alter the nightly increase in TSH. Chronic elevation of endogenous cortisol serum levels in patients with Cushing's disease revealed a heterogeneous pattern. In 2 patients serum TSH and thyroid hormone levels showed a normal 24-h rhythm, whereas the other 2 patients had low TSH serum levels. Acute treatment of 9 healthy volunteers with 0.5, 1 or 2 mg dexamethasone po at 23.00 h resulted in a significant dose-dependent suppression of mean basal TSH levels 9 h later. Treatment with 30mg of prednisone for 1 week in 7 patients with Crohn's disease did not influence basal TSH. The TSH response to TRH was only temporarily suppressed on day 3, but not on day 7 of treatment. The results suggest that under physiological conditions glucocorticoids have no regulatory influence on pulsatile and circadian TSH secretion.

show abstract

Section: Tablezcontrasting

confidence: 68%

The role of glucocorticoids in the regulation of thyrotropin

Brabant

Schuermeyer

et al. 1989

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…glucocorticosteroids suppressing TSH secretion. Although secondary/corticogenic hypothyroidism is known to occur in association with Cushing syndrome13,14 , pheochromocytoma resulting in secondary hypothyroidism has not been reported. The present patient also developed significant postoperative hyperglycemia which required insulin infusion for 48 hrs.…”

mentioning

confidence: 99%

Cushing Syndrome in an Infant Due to Cortisol Secreting Adrenal Pheochromocytoma: A Rare Association

Kumar

Kumar²,

Talukdar³

et al. 2010

Journal of Pediatric Endocrinology and Metabolism

View full text Add to dashboard Cite

Adrenocortical tumors are the most common cause of endogenous Cushing syndrome in infancy and early childhood. Cushing syndrome resulting from ectopic adrenocorticotrophic hormone (ACTH) producing tumor has been infrequently reported in adults. Cortisol secreting pheochromocytoma is rarely reported in literature. We report an eleven month old child presenting to us as Cushing syndrome with hypertension due to left adrenal tumor. He was treated with antihypertensives and left adrenalectomy was done under perioperative glucocorticoid coverage. Diagnosis of pheochromocytoma was made only after histopathology. Despite the rare association of Cushing syndrome and pheochromocytoma, preoperative diagnosis of pheochromocytoma is required for appropriate perioperative medical and anaesthetic management to prevent life threatening complications.

show abstract