Cushioning pellets based on microcrystalline cellulose – Crospovidone blends for MUPS tableting

Surface Modifiers on Composite Particles for Direct Compaction

“…Microcrystalline cellulose (MCC) is a commonly used dry binder that is obtained from cellulose and was first discovered by Battista and Smith in 1955 [ 152 , 153 ]. MCC, as a frequently used tablet excipient, is a green, renewable, cost-effective, and biocompatible polymer [ 154 ]. MCC is one of the most popular cellulose derivatives and is well known in the pharmaceutical industry for its outstanding tabletability.…”

“…The mechanism of improved dissolution and drug loading could be summarized as follows: (i) the disordered reorganization and dispersion of drug crystals leads to a reduction in particle size of the drug loaded inside the porous mannitol to the nanometer scale; (ii) corresponding improvement in wettability and dispersibility of co-treated particles; (iii) the larger pore volume of porous mannitol is conducive to the entry and penetration of the dissolution medium and improves the contact area and contact rate of the medium, thus, improving the dissolution of the drug. The applications of MCC were summarized in Table 4 [ 64 , 133 , 154 , 165 , 166 , 171 , 172 ].…”

Cushion-coated pellets for tableting without external excipients

“…The pellet-to-excipient ratio is an important parameter that influences the mechanical strength, disintegration time, mass and drug content uniformity of the resulting tablets, as well as the integrity of the tableted subunits (Bianchini et al, 1992;Debunne et al, 2004;Pinto et al, 1997aPinto et al, , 1997b. To address the risk of segregation in the mixtures of pellets and cushioning excipients, the use of fillers with a relatively large particle size or of placebo pellets was proposed, meeting most of the desired requirements (Beckert et al, 1998;Elsergany et al, 2020;Lundqvist et al, 1998;Lundqvist and Podczeck, 1997;Sántha et al, 2021;Wagner et al, 1999).…”