Customized and non-customized live-born birth-weight curves of single and uncomplicated pregnancies from the Burgundy perinatal network. Part I – methodology

Rousseau, Thierry; Durand-Maison, Olivia; Labruère-Chazal, Catherine; Tabard, Florine; Jébrane, Ahmed; Martz, Olivia; Benzenine, Éric; Cottenet, Jonathan; Shrivastava, Paul

doi:10.1016/j.jogoh.2017.05.004

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…found that the risk of large gestational weight for age is higher after FET compared with fresh embryo transfer and also natural conception 8 . In our study, BW after FET was even higher than the mean BW after natural conception in France between 2005 and 2013 (i.e., 3260 g ± 451.4 g) 19 (Fig. 1).…”

Section: Discussionmentioning

confidence: 42%

Cryopreserved embryo replacement is associated with higher birthweight compared with fresh embryo: multicentric sibling embryo cohort study

Anav

Phillips²,

Ferrières-Hoa

et al. 2019

Sci Rep

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Birth weight (BW) is higher after frozen embryo transfer (FET) than after fresh embryo replacement. No study has compared the BW of siblings conceived using the same oocyte/embryo cohort. The aim of this study was to determine whether the freezing-thawing procedure is involved in such difference. Multicenter study at Montpellier University Hospital, Clinique Ovo, Canada and Grenoble-Alpes University Hospital. The first cohort (Fresh/FET) included in vitro fertilization (IVF) cycles where the older was born after fresh embryo transfer (n = 158) and the younger after transfer of frozen supernumerary embryos (n = 158). The second cohort (FET/FET) included IVF cycles where older and younger were born after FET of embryos from the same cohort. The mean adjusted BW of the FET group was higher than that of the fresh group (3508.9 ± 452.4 g vs 3237.7 ± 463.3 g; p < 0.01). In the FET/FET cohort, the mean adjusted BW was higher for the younger by 93.1 g but this difference is not significant (3430.2 ± 347.6 g vs 3337.1 ± 391.9 g; p = 0.3789). Our results strongly suggest that cryopreservation is directly involved in the BW variation. Comparing BW difference between Fresh/FET cohort and FET/FET one, it suggests that parity is not the only responsible, increasing the role of cryopreservation step in BW variation.

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Section: Discussionmentioning

confidence: 42%

Cryopreserved embryo replacement is associated with higher birthweight compared with fresh embryo: multicentric sibling embryo cohort study

Anav

Phillips²,

Ferrières-Hoa

et al. 2019

Sci Rep

View full text Add to dashboard Cite

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Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?

Mariet

Mauny

Pujol

et al. 2018

Environment International

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AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios

Zimmerman,

Hernandez,

Yandell

et al. 2024

Preprint

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Background Fetal growth restriction (FGR) is a leading risk factor for stillbirth, yet the diagnosis of FGR confers considerable prognostic uncertainty, as most infants with FGR do not experience any morbidity. Our objective was to use data from a large, deeply phenotyped observational obstetric cohort to develop a probabilistic graphical model (PGM), a type of “explainable artificial intelligence (AI)”, as a potential framework to better understand how interrelated variables contribute to perinatal morbidity risk in FGR. Methods Using data from 9,558 pregnancies delivered at ≥ 20 weeks with available outcome data, we derived and validated a PGM using randomly selected sub-cohorts of 80% (n = 7645) and 20% (n = 1,912), respectively, to discriminate cases of FGR resulting in composite perinatal morbidity from those that did not. We also sought to identify context-specific risk relationships among inter-related variables in FGR. Performance was assessed as area under the receiver-operating characteristics curve (AUC). Results Feature selection identified the 16 most informative variables, which yielded a PGM with good overall performance in the validation cohort (AUC 0.83, 95% CI 0.79–0.87), including among “N of 1” unique scenarios (AUC 0.81, 0.72–0.90). Using the PGM, we identified FGR scenarios with a risk of perinatal morbidity no different from that of the cohort background (e.g. female fetus, estimated fetal weight (EFW) 3-9th percentile, no preexisting diabetes, no progesterone use; RR 0.9, 95% CI 0.7–1.1) alongside others that conferred a nearly 10-fold higher risk (female fetus, EFW 3-9th percentile, maternal preexisting diabetes, progesterone use; RR 9.8, 7.5–11.6). This led to the recognition of a PGM-identified latent interaction of fetal sex with preexisting diabetes, wherein the typical protective effect of female fetal sex was reversed in the presence of maternal diabetes. Conclusions PGMs are able to capture and quantify context-specific risk relationships in FGR and identify latent variable interactions that are associated with large differences in risk. FGR scenarios that are separated by nearly 10-fold perinatal morbidity risk would be managed similarly under current FGR clinical guidelines, highlighting the need for more precise approaches to risk estimation in FGR.

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Customized and non-customized live-born birth-weight curves of single and uncomplicated pregnancies from the Burgundy perinatal network. Part I – methodology

Cited by 3 publications

References 15 publications

Cryopreserved embryo replacement is associated with higher birthweight compared with fresh embryo: multicentric sibling embryo cohort study

Cryopreserved embryo replacement is associated with higher birthweight compared with fresh embryo: multicentric sibling embryo cohort study

Multiple pregnancies and air pollution in moderately polluted cities: Is there an association between air pollution and fetal growth?

AI-based analysis of fetal growth restriction in a prospective obstetric cohort quantifies compound risks for perinatal morbidity and mortality and identifies previously unrecognized high risk clinical scenarios

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