Customized mold brachytherapy for oral carcinomas through use of high-dose-rate remote afterloading apparatus

Ariji, Eiichiro; Hayashi, Nobuyuki; Kimura, Yasuo; Uchida, Tsuneko; Hayashi, Kuniaki; Nakamura, Takashi

doi:10.1016/s1079-2104(99)70253-2

Cited by 24 publications

(25 citation statements)

References 11 publications

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“…The applicator tubes were arranged so they encompassed the tumor area at almost equal intervals reported no recurrence or morbidity during the 26 months of follow-up. 10 We speculate that another reason we could not control the tumor in patient 1 was inadequate dose distribution around the distal portion of the fi rst molar because we had to place an applicator tube off the teeth. We must take into account extraction of the teeth before starting brachytherapy, which may be an obstacle to using the mold technique.…”

Section: Discussionmentioning

confidence: 97%

Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique

et al. 2007

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Radiotherapy of head and neck cancer has become more successful with the advances in treatment modalities and use of a multidisciplinary approach. Higher quality treatment and a team approach to radiotherapy have thus been required for head and neck cancer. This study presents the clinical experience of high-dose-rate (HDR) brachytherapy for head and neck cancer treated by a customized intraoral mold technique. Two patients are reported for whom we created dental prostheses as the radiation carriers for HDR brachytherapy of their head and neck cancers. HDR brachytherapy with the dental prostheses reported here was feasible and effective for eradicating the head and neck cancer. It has been demonstrated that HDR brachytherapy using a customized intraoral technique can be a treatment option for patients who are not candidates for surgery or external irradiation. It is strongly suggested that specialized dentists are needed who are familiar with not only the anatomy and function of the head and neck region but also radiotherapy. Dental radiologists should take responsibility for constructing irradiation prostheses. If they do, they have the potential to improve the quality of life of patients who undergo radiotherapy for head and neck cancer.

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Section: Discussionmentioning

confidence: 97%

Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique

et al. 2007

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“…The use of this technique has also been described in intracavitary radiotherapy for head and neck tumors [4][5][6]. The mold technique of HDR brachytherapy for head and neck cancer was first reported by Miyata et al [2] in 1979.…”

Section: Discussionmentioning

confidence: 99%

“…Although the combination of a mold and remote afterloading units has been used in the head and neck region, including the oral cavity [1][2][3], its use as a radical radiotherapy technique has been extremely limited due to the low flexibility of the connection catheters. Several reports of superficial carcinoma of the oral cavity that were successfully or unsuccessfully treated by a technique combining a mold and a remote afterloading unit with a 192 Ir microsource after external radiotherapy or chemoradiotherapy were published in 1998-1999 [4][5][6], but this modality has not become established as a standard treatment. In this article, we report the results for nine patients with oral cavity cancer who were treated using the combined technique.…”

Section: Introductionmentioning

confidence: 99%

High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer

et al. 2011

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“…The limited use of intracavitary irradiation is attributable to the limited treatment provided for superficial oral tumors, and the absence of oral equivalents of the off-the-shelf applicators used to treat cancer of the uterine cervix, such as the tandem and ovoid applicator. For superficial oral cavity tumors, some authors (including us) have reported the effectiveness of HDR brachytherapy using a mold [7-12]. However, these previous studies only included a few cases with short follow-up periods [7-12].…”

Section: Introductionmentioning

confidence: 99%

High-dose-rate brachytherapy using molds for lip and oral cavity tumors

et al. 2015

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BackgroundHigh-dose-rate (HDR) brachytherapy using the mold technique is a less invasive treatment for early lip and oral cavity cancer. However, limited reports exist regarding the feasibility of this method. In this retrospective study, we evaluated the outcome of this therapy and investigated its feasibility for lip and oral cavity tumors.MethodsBetween May 2002 and December 2010, 17 patients (median age, 80.0 years) with histologically confirmed squamous cell carcinoma of the lip or oral cavity were treated by means of HDR brachytherapy using the mold technique after external beam radiotherapy (EBRT). Tumor sites included the buccal mucosa in eight cases, the gingiva in three cases, the lips in two cases, the floor of the mouth in two cases, and the hard palate in two cases. For all patients, EBRT (30 Gy/15 fractions), was performed before HDR brachytherapy. Two 6-Gy fractions were delivered twice daily for 2 days a week with an interval of 6 hours between the fractions. The total HDR brachytherapy dose was 24 Gy. Prior to EBRT, two patients with neck metastasis underwent neck dissection, and one patient with an exophytic tumor underwent tumor resection.ResultsThe median follow-up period was 53.4 (range, 4.8–83.4) months. Of the 17 patients, 14 (82.4%) achieved a complete response, and three (17.6%) displayed a partial response.The overall 3- and 5-year survival rates were both 68.8%, the 3- and 5-year disease-specific survival rates were both 86.7%, and the 3- and 5-year local control rates were both 54.1%. Seven patients developed local recurrence at a median time of 3.4 (range, 1.7–29.1) months after treatment. Nodal and lung metastases occurred separately in two patients. By the end of the follow-up period, two patients had died of the primary disease and four patients had died of other causes.ConclusionsAlthough there is a need to improve the technical aspects of the treatment protocol, HDR brachytherapy using the mold technique might be a therapeutic option for superficial lip or oral cavity tumors, especially in older patients who have a poor performance status or are in poor physical condition.

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Customized mold brachytherapy for oral carcinomas through use of high-dose-rate remote afterloading apparatus

Cited by 24 publications

References 11 publications

Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique

Experience of high-dose-rate brachytherapy for head and neck cancer treated by a customized intraoral mold technique

High dose rate brachytherapy using molds after chemoradiotherapy for oral cavity cancer

High-dose-rate brachytherapy using molds for lip and oral cavity tumors

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