Cutaneous adverse drug reactions: a 9-year study from a South Indian Hospital

Sushma, M; Noel, M. V.; Ritika, M. C.; James, Jerin; Guido, Shoba

doi:10.1002/pds.1105

Cited by 63 publications

(92 citation statements)

References 7 publications

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“…The results comply with earlier studies. 16,19,23 Out of the 100 cases of ACDRs in our study, dechallenge was done in all the cases and it was positive in 84 of them. Although rechallenge was not done in any of our cases due to practical problems, these cases were considered definite because rechallenge data was available in the form of past history of similar reaction with the same drug.…”

Section: Discussionmentioning

confidence: 77%

A study of adverse cutaneous drug reactions in the department of dermatology of a teaching hospital in Jamnagar, India

Dhanani

Sukhlecha

2017

Int J Basic Clin Pharmacol

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Background: Adverse drug reactions cause significant morbidity and mortality in health care set up. They are responsible for a significant number of hospital admissions. The data for adverse cutaneous drug reactions (ACDRs) is limited our country. Thus, the present study emphasises on the need of an effective adverse drug reaction reporting programme.Methods: A prospective study to assess the ACDRs in Dermatology department was conducted in a teaching hospital of India. Male to female ratio, most common class of drug, individual drugs causing ACDRs, common types of ACDRs were studied. Other parameters like causality assessment, preventability and seriousness of ACDRs were also studied.Results: A majority of the patients (38%) with ACDR were in the age group of 25-44 years followed by 45-64 years (31%). The rate of ACDRs was more in males (54%). The most frequent ACDR reported was maculopapular rash (38%), followed by urticaria (19%) and fixed drug eruptions (12%). Most of the reactions (93%) were bizarre/ unpredictable in nature. Amongst drug groups, antimicrobials (48%) were most frequently associated with ACDRs followed by NSAIDs (30%) and antiepileptics (12%). Most of the reactions (94%) were mild-moderate in nature. Only 9% of ACDRs reported in this study were preventable. Paracetamol was the most common offending drug followed by cotrimoxazole, ibuprofen, amoxicillin, phenytoin in decreasing order. Causality assessment found ACDRs in probable category (68%) using WHO-UMC criteria.Conclusions: It is important to monitor and report adverse drug reactions in order to promote safe and rational use of medicines.

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Section: Discussionmentioning

confidence: 77%

A study of adverse cutaneous drug reactions in the department of dermatology of a teaching hospital in Jamnagar, India

Dhanani

Sukhlecha

2017

Int J Basic Clin Pharmacol

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“…15 Por outro lado, alterações cutâneas de outras origens podem ser diagnosticadas incorretamente como reações a drogas. 1 A idade média dos pacientes neste trabalho foi de 43,9 anos, com desvio-padrão de ± 21,6 anos, semelhante à encontrada por Sushma et al, 16 trabalho no qual a maioria dos pacientes acometidos por reações cutâneas adversas desencadeadas por drogas estava na faixa etária de 21 a 40 anos de idade. Outros estudos obtiveram maior incidência de 21 a 30 anos (22,9%);1 20 a 39 anos (52,2%);17 40 a 50 anos (20%)18 e 51 a 60 anos (19%).…”

Section: Discussionunclassified

“…Outros estudos obtiveram maior incidência de 21 a 30 anos (22,9%);1 20 a 39 anos (52,2%);17 40 a 50 anos (20%)18 e 51 a 60 anos (19%). 19 Quanto ao discreto maior acometimento do sexo feminino (51,2% dos pacientes), assemelha-se a incidências encontradas na literatura: 58,8%;18 64,5%19 e 72,3%,1 contrastando, entretanto, com o encontrado por Sushma et al, 16 no qual o sexo masculino (52%) predominou sobre o feminino (48%).…”

Section: Discussionunclassified

Reações cutâneas desencadeadas por drogas

Silvares¹,

Abbade²,

Lavezzo³

et al. 2008

An. Bras. Dermatol.

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“…Así, la latencia encontrada en nuestro trabajo, de 19,6 días (rango de 1 a 90 días) es la que clásicamente se describe en la literatura. Otra observación destacable, como se muestra en la Tabla 2, y coincidente con otras publicaciones, es que las reacciones más severas presentaron mayor latencia 23 .…”

Section: Discussionunclassified