Cutaneous and mucosal mucormycosis mimicking pancreatic panniculitis and gouty panniculitis

Requena, Luis; Sitthinamsuwan, Panitta; Santonja, Carlos; Fernández‐Figueras, María Teresa; Rodríguez‐Peralto, José Luis; Argényi, Zsolt B.; Torrelo, Antonio; Cerroni, Lorenzo; Kutzner, Heinz

doi:10.1016/j.jaad.2011.06.024

Cited by 32 publications

(17 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They described similar crystals within the subcutis in association with fungal infection. Interestingly, the crystals secondary to mucor were refractile upon examination with polarized light, 18 which was different from our patient. Also, our case showed negativity for the PAS staining method.…”

Section: Discussioncontrasting

confidence: 87%

See 1 more Smart Citation

Gemcitabine‐associated livedoid thrombotic microangiopathy with associated sclerema neonatorum‐like microscopic changes

et al. 2012

View full text Add to dashboard Cite

Gemcitabine is a deoxycytidine analog antimetabolite that is now accepted as first-line treatment for advanced and metastatic pancreatic carcinoma. Gemcitabine-related thrombotic microangiopathy associated with systemic hemolytic-uremic syndrome or thrombotic thrombocytopenia purpura has rarely been described. Herein, we report a patient who developed a livedoid thrombotic microangiopathy with no signs of associated hemolytic-uremic syndrome. Cutaneous thrombotic microangiopathy occurred after the administration of his 17th cycle and a cumulative dose of 53.65 g/m(2) of gemcitabine. Some authors have suggested that this toxicity may be dose-related, and a 10th cycle or a cumulative dose of 9-56 g/m(2) have been proposed as the prothrombotic threshold. Interestingly, dermatopathologic findings were limited to the subcutis and they consisted of small-vessel occlusion by intravascular fibrin and leukocytes, vessel wall thickening and endothelial cell swelling. Surprisingly, we observed some structures arranged radially with needle-shaped clefts resembling those of sclerema neonatorum. Awareness of this potential cutaneous toxicity by dermatologists and dermatopathologists is extremely important.

show abstract

Section: Discussioncontrasting

confidence: 87%

“…Recently, Requena et al 18 completed a histopathological study of 13 cases of mucormycosis panniculitis. They described similar crystals within the subcutis in association with fungal infection.…”

Section: Discussionmentioning

confidence: 99%

Gemcitabine‐associated livedoid thrombotic microangiopathy with associated sclerema neonatorum‐like microscopic changes

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Our case is exceptional because only fourteen cases, in two previously published case reports, have described a cutaneous fungal infection mimicking pancreatic panniculitis. In the article by Requena et al, thirteen cases of cutaneous and mucosal mucormycosis revealed ‘ghost’ adipocytes histopathologically, closely resembling those seen in pancreatic panniculitis or in our case . In response to the Requena article, Colmenero et al report a case of cutaneous aspergillosis also imitating pancreatic panniculitis .…”

supporting

confidence: 73%

“…In the article by Requena et al, thirteen cases of cutaneous and mucosal mucormycosis revealed 'ghost' adipocytes histopathologically, closely resembling those seen in pancreatic panniculitis or in our case. 7 In response to the Requena article, Colmenero et al report a case of cutaneous aspergillosis also imitating pancreatic panniculitis. 8 The mechanism behind the development of a lobular panniculitis resembling the ghost cells of pancreatic panniculitis is thought to stem from the large amount of extracellular lipase produced by fungi of the family Mucoraceae, of which Rhizopus and Mucor are members, as well as other fungi such as Aspergillus, Candida, and Penicillium.…”

mentioning

confidence: 99%

Two Pink Nodules in a Patient with Acute Myeloid Leukemia

2014

View full text Add to dashboard Cite

“…Ghost‐like adipocytes have been previously reported in cutaneous mucormycosis . Earlier investigators suggested ghost‐like adipocytes in these cases were induced by extracellular lipase formation by infective fungi.…”

mentioning

confidence: 94%