Cutaneous angiosarcoma as a delayed complication of radiation therapy for carcinoma of the breast

Angiosarcoma of the Breast

“…Results from fine-needle aspiration and punch biopsies are generally not diagnostic and can be misleading because they may resemble those of other entities, such as radiation-related morphea or metastatic breast carcinoma (6,7,13,18). Findings from full-thickness incisional biopsies or excisional biopsy specimens should be conclusive, and these procedures are indicated if angiosarcoma is suspected (4,7,13,18).…”

“…Secondary angiosarcoma can manifest as either a palpable mass or as just an alteration in skin color (1,6,7). The size and location of palpable masses vary from small cutaneous nodules (the cutaneous subtype) (13) to large lumps that constitute the entire breast (the intraparenchymal subtype).…”

“…The skin can show different morphologies such as macules, papules, and vesicles. Advanced disease is typically marked by edema and ulcerative lesions in the breast (7). Angiosarcoma usually manifests with a mixture of the above-mentioned features, either in a single region or multifocally.…”

“…Findings from full-thickness incisional biopsies or excisional biopsy specimens should be conclusive, and these procedures are indicated if angiosarcoma is suspected (4,7,13,18).…”

Uterine Epithelioid Angiosarcoma on F-18 FDG PET/CT

“…In contrast to conventional angiosarcoma, epithelioid angoisarcoma has been defined as a unique morphologic subtype of angiosarcoma, in which the malignant endothelial cells have a predominantly (or exclusively) epithelioid appearance [2]. Although epithelioid angiosarcomas can arise from any blood or lymph vessel, they most commonly arise on the face, scalp, [3] soft tissues, breast, spleen, liver and bone [4].…”