Cutaneous angiosarcoma of head and neck

Abstract

Cutaneous angiosarcoma is a rare aggressive tumor of capillary and lymphatic endothelial cell origin. Cutaneous angiosarcoma of the head and neck regions seems to be a distinctive neoplasm with characteristic clinicopathologic features that differ from angiosarcoma in other anatomic locations. Angiosarcoma, regardless of their setting, has a bad prognosis. We presented here a case of 80 years old male, with multiple nontender grouped purple to red hemorrhagic vesicular and bullous lesions over left lower cheek and upper neck area, with bilateral cervical lymph nodes since 1 month. Computed tomography thorax showed nodular opacities in the right upper and midzones. Excisional biopsy showed characterstic “dissection of collagen” with mild nuclear atypia. Immunohistochemistry showed tumor cell positive for CD-31 and Fli-1. Patient died within 1 month of presentation.

Cutaneous angiosarcoma of the head and neck resembling rosacea: A case report

“…1,2,3,7 Current treatment modalities include complete surgical resection, radiation therapy and chemotherapy. 2,4,5 Chemotherapy is recommended for metastatic disease, and chemotherapeutic agents that have shown activity against angiosarcoma include anthracyclines and taxanes. 2,5 However, cutaneous angiosarcoma of the head and neck can present with multifocal lesions, indistinct borders and extensive skin involvement due to clinically undetectable intradermal spread.…”

“… 6 , 7 Studies have shown that only half of patients survive over 15–18 months. 1 , 4 Prognostic factors include tumor size greater than 5 cm in diameter, depth of invasion, margin status, recurrence and metastases. 1 , 2 , 3 , 7 …”

“…1 However, the diagnosis is often delayed because lesions can be confused with rosacea, hemangiomas, hematomas, eczema or infection. 2,4,5 Therefore, early clinical suspicion and biopsy of skin lesions that resemble angiosarcoma should be considered.…”

Angiosarcoma Clinically Mimicking a Targetoid Hemosiderotic Hemangioma

“…The variation in clinical presentation and the lack of disease awareness contribute to the difficulty in diagnosis 3 ; however, early detection and intervention is critical for improved prognosis. The size of lesion at presentation is an important prognostic factor for cutaneous angiosarcoma 3 , and a delayed diagnosis may lead to substantial challenges in treatment 4 . Perez et al reported that a tumor size less than 5cm was associated with a significantly improved overall and recurrence-free survival compared to a tumor size greater than 5cm 5 .…”

Cutaneous angiosarcoma simulating as pyoderma in a middle-aged Indian female: A rare case report

“…It mainly occurs in fair skinned males (sex ratio of 3:1), at an average age ranging from 60 to 80 years. [1] Very few Indian case reports, mostly males, have been documented till date.…”