Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2

Wasik, Mariusz A.; Sackstein, Robert; Novick, Daniela; Butmarc, Janet; Zhang, Qian; Vonderheid, Eric C.; Kadin, Marshall E.

doi:10.1016/s0046-8177(96)90408-6

Cited by 21 publications

(5 citation statements)

References 37 publications

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“…18,27 The extremely rare NK-like T-cell-derived lymphomas include the clinicopathological entity of hepatosplenic ␥␦ T-cell lymphoma 28 and may, furthermore, arise at a variety of other extranodal sites among which the intestine could play an important role. 10,20,29,30 Normal human jejunal IELs are mainly TCR␣␤ ϩ CD3 ϩ CD8 ϩ CD5 low , and in situ analyses have shown lack of proteins carrying out cell-mediated cytolysis, such as granzyme B, perforin, and Fas ligand, indicating that IELs are resting cytotoxic T cells. 31,32 Upon activation, however, expression of granzyme B and Fas ligand is rapidly up-regulated.…”

Section: Discussionmentioning

confidence: 99%

Most CD56+ Intestinal Lymphomas Are CD8+CD5− T-Cell Lymphomas of Monomorphic Small to Medium Size Histology

Chott

Haedicke

Mosberger

et al. 1998

The American Journal of Pathology

202

142

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The expression of the natural killer (NK) cell marker CD56 has been reported to occur in NK cell lymphomas/leukemias and a small group of peripheral T-cell lymphomas but has not been studied extensively in primary intestinal non-B-cell lymphomas. Normal human jejunal intraepithelial lymphocytes (IELs) are mainly T-cell receptor (TCR)-alphabeta+CD3+CD8+CD5low and include an approximately 15% fraction of CD56+ cells that could be the cells of origin for CD56+ intestinal T-cell lymphoma (ITL). To test this hypothesis, 70 cases diagnosed as ITL were immunophenotyped, and 15 CD56+ cases (21%) were identified. The majority of the CD56+ lymphomas was of monomorphic small to medium-sized histology, shared the common phenotype betaF1+/-CD3epsilon/cyt+CD8+CD4-CD5-CD57-TIA-1+ and had clonally rearranged TCR gamma-chain genes. In contrast, the CD56- lymphomas were mainly composed of pleomorphic medium and large cells or had a morphology most consistent with anaplastic large-cell lymphoma and were mostly CD8-. These findings suggest that the majority of CD56+ intestinal lymphomas are morphologically and phenotypically distinct T-cell lymphomas most likely derived from activated cytotoxic CD56+CD8+ IELs. Some overlapping histological and clinical features between CD56+ and CD56- ITLs indicate that the former belong to the clinicopathological entity of ITL. The consistent expression of cytotoxic-granule-associated proteins introduces ITL (both CD56+ and CD56-) into the growing family of usually aggressive extranodal lymphomas of cytotoxic T-cell and NK-cell derivation. In contrast to putative NK-cell lymphoma of the sinonasal region, intestinal NK-cell lymphoma seems to be very rare.

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Section: Discussionmentioning

confidence: 99%

Most CD56+ Intestinal Lymphomas Are CD8+CD5− T-Cell Lymphomas of Monomorphic Small to Medium Size Histology

Chott

Haedicke

Mosberger

et al. 1998

The American Journal of Pathology

202

142

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“…On the basis of morphology, immunophenotype, functional NK cell activity, and expression of cytotoxic molecules, NK cell neoplasms can be divided into immature and mature categories 5, 7, 15–20. In the last 2 decades, a number of patients with CD56‐positive (CD56 + ) blastoid hematopoietic tumors have been reported in the literature, suggesting the existence of neoplasms arising from immature NK cells 6, 16–32. In contrast, it is believed that aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type originate from mature NK cells 5, 9, 10, 15…”

Section: Clinicopathologic Categorizations and Featuresmentioning

confidence: 99%

Natural killer cell neoplasms

Liang

Graham

2008

Cancer

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“…Only very few cases of primary cutaneous non-T non-B CD4 ϩ CD56 ϩ lymphomas have been reported in the literature, including a cooperative series of seven cases (Petrella et al, 1999) and a few single cases (Adachi et al, 1994;Brody et al, 1995;Dummer et al, 1996;Wasik et al, 1996;Savoia et al, 1997). Some of these cases are not true primary cutaneous lymphomas.…”

Section: Do Primary Cutaneous Non-t Non-b Cd4 ⍣ Cd56 ⍣ Lymphomas Belong To the Myelo-monocytic Lineage?mentioning

confidence: 99%

Do Primary Cutaneous Non-T Non-B CD4+CD56+ Lymphomas Belong to the Myelo-Monocytic Lineage?

Bagot

Bouloc

Charue

et al. 1998

Journal of Investigative Dermatology

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THE JOURNAL OF INVESTIGATIVE DERMATOLOGY was found: the analysis of the distribution of allelic frequencies between porphyric and control subjects gave a p ϭ 0.007 by two-tailed Fisher's exact test, whereas the number of mutated subjects gave a p ϭ 0.012. No significant differences were observed between the type I and II PCT subgroups for both mutations (p Ͼ 0.6). No differences were also observed between serum iron, ferritin, transferrin, and porphyrin levels or for urinary porphyrin concentrations between mutated and nonmutated (single or both mutations) PCT patients (p at least Ͼ 0.21, data not shown). This finding suggests no apparent dependence of HFE variants on iron metabolism of PCT subjects or on PCT intensity. Finally, HCV positivity was not significantly associated with the same mutations (Cys282Tyr mutation was found in three of seven HCVϩ patients, as opposed to eight of 13 for His63Asp, p ϭ 0.64).In conclusion, the group of PCT patients studied presented only a statistically significant association with a HFE Cys282Tyr mutation. This result cannot support the fact that the HFE Cys282Tyr variant may be widely involved in PCT pathogenesis, even if a possible role of this altered molecule as a PCT trigger cannot be excluded in a patients' subset.

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Cutaneous CD56+ large T-cell lymphoma associated with high serum concentration of IL-2

Cited by 21 publications

References 37 publications

Most CD56+ Intestinal Lymphomas Are CD8+CD5− T-Cell Lymphomas of Monomorphic Small to Medium Size Histology

Most CD56+ Intestinal Lymphomas Are CD8+CD5− T-Cell Lymphomas of Monomorphic Small to Medium Size Histology

Natural killer cell neoplasms

Do Primary Cutaneous Non-T Non-B CD4+CD56+ Lymphomas Belong to the Myelo-Monocytic Lineage?

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