Cutaneous changes in internal malignancy: Study from a tertiary care center

Hassan, Iffat; Zeerak, Sumaya; Kuchay, Sanaullah; Bashir, Saima; Bhat, Yasmeen Jabeen; Syed, Mustafa; Rasool, Farhan; Sheikh, Gousia; Sajad, Peerzada

doi:10.4103/0378-6323.196321

Cited by 7 publications

(24 citation statements)

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“…Among the two patients below the age of 20 years, one was a six-year-old child with Wilms' tumor. The sex ratio in our study was different from a study by Hassan et al, in which 139 (55.6%) patients were males and 111 (44.4%) patients were females [9].…”

Section: Discussioncontrasting

confidence: 99%

A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India

Puri¹,

Brar²,

Brar³

2021

Our Dermatol Online

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Introduction: Cutaneous metastases may precede a malignancy and, in other cases, herald the recurrence of a malignancy after surgery. Aim: To determine the significance of cutaneous manifestations in patients with an internal malignancy and to observe the various types of carcinomas in patients attending a dermatology OPD. Methods: This was a prospective hospital-based study undertaken to observe the cutaneous features in a dermatology OPD in patients coming from the oncology department of a medical college. Results: The commonest malignancy in males was a lung carcinoma, observed in 5.50% of the patients, followed by a prostate carcinoma, observed in 4.58% of the patients, an esophagus carcinoma, observed in 4.12% of the patients, and a penis carcinoma, observed in 2.29% of the patients. Specific cutaneous manifestations included cutaneous metastatic infiltrates, observed in 5.04% of the patients, and carcinoma erysipeloides, observed in 1.37% of the patients. Discussion: Skin metastases may herald the recurrence of a malignancy after treatment and usually indicate a poor prognosis.

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Section: Discussioncontrasting

confidence: 99%

A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India

Puri¹,

Brar²,

Brar³

2021

Our Dermatol Online

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“…This goes in accordance with other studies in literature which shows that the frequency of cutaneous metastases is low, ranging from 0.8% -9%. 5,6,7,8,9 among which, studies from south east Asia also showed similar results ranging from 0.8%-6.93%. However in our case this finding may be falsely low as we included only those patients who were referred to us.…”

Section: Discussionmentioning

confidence: 57%

“…15 This cutaneous change has been reported in literature to many drugs including sorafenib and capecitabine . 7,10 Several studies have shown that chemotherapy can cause nail changes such as pigmentary disturbances, nail dystrophy, leukonychia, onycholysis and others. Most of the nail changes seen were possibly chemotherapy induced.…”

Section: Discussionmentioning

confidence: 99%

Dermatological Manifestations in Cancer Patients: A Hospital Based Study

Thapa

2018

Nep. Med. Coll. J.

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Skin can show various manifestations in patients suffering with malignancy, which may be specific or non specific. In absence of any available literature on this issue, we conducted this study to know the dermatological conditions affecting Nepalese patients with malignancy. A total of 62 patients who were referred for dermatological consultation both from out-patient department and in-patient department of Nepal Cancer Hospital were included in this study. Data including demographic variables, type of malignancy, duration since diagnosis, chemotherapeutic agents administered and dermatological manifestation were recorded. The frequency of Dermatological manifestation in cancer patients was found to be 0.41%. There were 56% females and 44% males. Mean age of presentation was 44 years. These patients had primary malignancy as carcinoma breast in 31%, lung carcinoma 21%, carcinoma colon 16%, carcinoma rectum 8%, carcinoma pancreas 7% and 3% each had carcinoma prostate, carcinoma stomach, carcinoma ovary and oral carcinoma and Ewing sarcoma. The mean duration of presentation of primary carcinoma was 8 months. The most frequent dermatoses was eczema in 39%, followed by infection 25%, pruritus 14%, insect bite hypersensitivity 3.2%, disorder of pilosebaceous unit 3.2%, urticaria 3.2%, pigmentary changes 3.2%, nail involvement 3.2%, drug rash 2%, vesiculo-blistering disorder 2% and cutaneous metastasis in 2%. In absence of screening program, we found a very low frequency of cutaneous manifestation in patients with malignancy in our study. We recommend a prospective long term follow-up study with institution of screening and awareness program.

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“…This was similar to the findings in studies by Ayyamperumal et al and Hassan et al, where the male to female ratio was 1.8:1 and 1.3:1 respectively. 1,9 In our study, the most common malignancy (Table 3) was carcinoma of the breast, which was observed in 23.38% of the patients, followed by carcinoma of the cervix and leukemia, each in 9.17%, lymphomas, in 8.71%, carcinoma of lung in 5.50%, prostate in 4.58%, ovary and esophagus in 4.12% each, larynx in 3.66%, carcinoma tongue, endometrium, brain tumors in 3.21% each, carcinoma with unknown primary in 2.75%, carcinoma of bladder, penis, colon in 2.29% each, rectum in 1.83%, carcinoma of the stomach, thyroid, and renal cell carcinoma in 1.37% each, carcinoma of the , in 2.29% of the patients, pancreas, hepatocellular carcinoma in 0.91% each, and nasopharyngeal carcinoma in 0.45% of the patients. This is in contrast to findings by Wani et al, Hassan et al and Rajagopal et al which determined carcinoma of esophagus (19%), colorectal carcinoma (20%) and lymphomas (8%), respectively as the leading causes of malignancies.…”

Section: Resultsmentioning

confidence: 99%

A study on the cutaneous manifestations of patients with internal malignancy attending a cancer center in Kanyakumari District

et al. 2021

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Background: Cutaneous metastasis from an internal malignancy is rare and usually occurs at the later stages. Cutaneous changes may also be the presenting feature of some underlying malignancies. To determine the frequency of cutaneous manifestations in cancer patients attending the Cancer centre of Sree Mookambika Institute of Medical Sciences, Kanyakumari.Methods: This was a prospective hospital-based study. 218 patients with malignancies involving various organs, attending the Cancer Centre of Sree Mookambika Institute of Medical Sciences, Kanyakumari, were recorded for a period of 6 months from October 2020 to February 2021. Approval from the Institutional research ethical committee was obtained.Results: In our study, the most common non-specific cutaneous manifestation was generalized pruritis, observed in 17.88% of the patients, followed by acquired ichthyosis in 12.38% of the patients, and herpes zoster in 11.46% of the patients. Specific cutaneous manifestations included cutaneous metastatic infiltrates, observed in 5.04% of the patients.Conclusions: Skin metastases may herald the recurrence of a malignancy after treatment and usually indicate a poor prognosis.

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Cutaneous changes in internal malignancy: Study from a tertiary care center

Cited by 7 publications

References 0 publications

A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India

A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India

Dermatological Manifestations in Cancer Patients: A Hospital Based Study

A study on the cutaneous manifestations of patients with internal malignancy attending a cancer center in Kanyakumari District

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