Cutaneous collagenous vasculopathy in a middle‐aged woman with a history of prothrombin <scp>G20210A</scp> thrombophilia

Eldik, Hysem; Leisenring, Nathan H.; Al‐Rohil, Rami N.; Marano, Anne L.

doi:10.1111/cup.13895

Cited by 6 publications

(3 citation statements)

References 18 publications

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“…30 A procoagulant state in the context of CCV has been previously reported in the literature, specifically in a middle-aged woman with a history of prothrombin G20210A thrombophilia and biopsy-proven CCV. 31 Vascular thrombosis is a stimulus to endogenous nitrous oxide release from endothelium and leads to vascular relaxation hallmarked by vascular dilatation. 32 CCV is primarily reported in the middle-aged and elderly but also younger individuals.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

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Cutaneous collagenous vasculopathy is a rare pauci‐inflammatory, superficial, cutaneous vasculopathy characterized by progressive fine‐branching telangiectasias clinically, while light microscopically one observes dilated venules and capillaries within the superficial dermis exhibiting excessive Type IV collagen within the vessel wall. We present three cases of collagenous vasculopathy. Two cases were associated with certain autoimmune stigmata, including a positive serologic anti‐endothelial cell antibody assay and positive lupus anticoagulant in one, while the third case had positive anti‐ribonucleoprotein (RNP) antibodies. The latter case was associated with chronic hydroxyurea therapy for an underlying myeloproliferative disorder. We explore the role of immune‐ and non‐immune‐based endothelial cell injury in the pathogenesis of collagenous vasculopathy.

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Section: Discussionmentioning

confidence: 99%

Cutaneous collagenous vasculopathy: A report of three cases

et al. 2022

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“…розацеа [2], а также различные злокачественные новообразования, в том числе миелодиспластический синдром [6], карцинома молочной железы [9,11,15], карцинома легких [8], карцинома яичников [10], карцинома почек [13], базально-клеточная карцинома [4,19]. Один пациент страдал тромбофилией [18], некоторые пациенты не имели никаких сопутствующих заболеваний [7].…”

Section: актуальностьunclassified

Rare case of cutaneous collagenous vasculopathy in a patient with chronic HCV infection 1b subtype

Shpiluyk

Белоусова²,

Sulima

et al. 2022

Vestnik dermatologii i venerologii

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The article is devoted to a rare disease of cutaneous collagenous vasculopathy (CCV), which is characterized by common leather telangiectasias and specific histological signs: extended capillaries in the surface layers of the dermis, the walls of which are thickened due to hyaline deposits containing type IV collagen. According to literature, there are no publications about CCV in Russian sources. In foreign literature, only 60 cases are described, the first of which is mentioned in 2000. The patient turned to the EXCLUSIVE medical clinic to resolve the issue of the tactics of treatment of chronic HCV-infection 1b subtype and complaints of common telangiectasia on the skin and mucous membrane of both sclera, without subjective sensations. The first rashes appeared in 2008 and gradually progressed. When performing histological examination, expanded capillaries were found in the surface layers of the dermis, the walls of which are thickened due to protein deposits containing type IV collagen. The described case of CCV is the first in Russian literature and shows the need for histological and immunohistologycal studies to establish a final diagnosis.

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“…11 In addition, CCV has been reported in hypercoagulable patients, demonstrating another route for endothelial damage, with 1 patient being heterozygous for prothrombin G20210A, a report of CCV in a patient with cryofibrinogenemia, and another patient being found positive for lupus anticoagulant. 11,12 Drugs also have been thought to influence CCV, including corticosteroids, lithium, thiothixene, interferon, isotretinoin, calcium channel blockers, antibiotics, hydroxyurea, and antidepressants. 7,11 The diagnosis of CCV is confirmed using light microscopy and collagen-specific immunostaining.…”

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confidence: 99%