The complaint of itch is common in patients with AIDS and HIV infection. Inspection of the skin often reveals a dermatosis, but precise diagnosis is not always easy which makes it difficult for effective treatment. In HIV-positive patients with itch, as well as common dermatoses, one often has to deal with atypical and even new skin diseases. Many of these are papular, papulo-vesicular or papulo-pustular. This article is a protocol for the diagnosis and treatment of itch in these patients.