Cutaneous effects of the most commonly used antidepressant medication, the selective serotonin reuptake inhibitors

Krasowska, Dorota; Szymanek, Magdalena; Schwartz, Robert A.; Myśliński, Wojciech

doi:10.1016/j.jaad.2006.10.020

Cited by 58 publications

(33 citation statements)

References 49 publications

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“…Growing bodies of data also showed that psychological stress can be associated with hair loss and vitiligo . Rigorous review and analysis of the literature suggested that many commonly prescribed drugs, for example, selective serotonin reuptake inhibitor (SSRI) could cause temporary hair loss . At the same time, our previous study indicated that the antidepressant fluoxetine induces melanogenesis both in vitro and in vivo, and 5‐HTR1A is one of the involved pathways in the regulation of melanogenesis by fluoxetine in B16F10 cells .…”

Section: Introductionmentioning

confidence: 99%

Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice

Liao

Zhou

et al. 2017

Experimental Dermatology

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Growing bodies of data show that psychological stress can be associated with hair loss and vitiligo. Researchers have revealed that stress could indeed inhibit hair growth in vivo, but the relationship between chronic stress and melanogenesis remains unknown. In this study, we established two types of stress models, chronic restraint stress (CRS) and chronic unpredicted mild stress (CUMS) mice models, and explored the possible role of stress in mice hair follicle melanogenesis. We found that stress changed hippocampal morphology, decreased 5-HT level in brain and skin and down-regulated 5-HT1A receptor expression in hippocampal CA1 region and skin. The alterations of 5-HT and 5-HT1A receptor might be a threshold of central stress to associate with the behaviour changes. Both two stresses caused cellular damage of melanocytes and inhibition of keratinocytes proliferation in HF, which made the synthetic pigment loss. CRS which was considered primarily as a "psychological" stressor had the lower melanin production in HF, as well as the level of 5-HT in skin was down-regulated more than those in CUMS group.

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Section: Introductionmentioning

confidence: 99%

Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice

Liao

Zhou

et al. 2017

Experimental Dermatology

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“…The observed comorbidity may reflect different side effects from medication [51], [52], [53]; most prominently seen with SSRIs (Selective Serotonin Reuptake Inhibitors for treatment of depression) that have been associated with cutaneous reactions, including alopecia, and migraine [54]. Also, frequently prescribed oral contraceptives are associated with migraines [55].…”

Section: Resultsmentioning

confidence: 99%

Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

et al. 2011

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Electronic patient records remain a rather unexplored, but potentially rich data source for discovering correlations between diseases. We describe a general approach for gathering phenotypic descriptions of patients from medical records in a systematic and non-cohort dependent manner. By extracting phenotype information from the free-text in such records we demonstrate that we can extend the information contained in the structured record data, and use it for producing fine-grained patient stratification and disease co-occurrence statistics. The approach uses a dictionary based on the International Classification of Disease ontology and is therefore in principle language independent. As a use case we show how records from a Danish psychiatric hospital lead to the identification of disease correlations, which subsequently can be mapped to systems biology frameworks.

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“…Therefore, manipulating serotonin levels may result in abnormal cutaneous or visceral manifestation13. The ability of serotonin to induce and augment platelet aggregation following vascular inflammation may explain the vasculitic reaction.…”

Section: Discussionmentioning

confidence: 99%

Sibutramine (Reductil®)-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

Han

Choi

et al. 2011

Ann Dermatol

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A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil®, Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine.

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Cutaneous effects of the most commonly used antidepressant medication, the selective serotonin reuptake inhibitors

Cited by 58 publications

References 49 publications

Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice

Effects of two chronic stresses on mental state and hair follicle melanogenesis in mice

Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts

Sibutramine (Reductil®)-Induced Cutaneous Leukocytoclastic Vasculitis: A Case Report

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