Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits

Murphy, James C.; Watson, E.S.; Wirth, Philip W.; Skierkowski, Paul; Folk, R.M.; Peck, Gary L.

doi:10.1016/0300-483x(79)90058-1

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…The objective of this study was not only to investigate the antibacterial efficacy of the smallest colloidal silver and to apply its bacteriostasis to textile fabrics but also to show the laundering durability of the bacteriostasis of the silver-treated woven fabric and to prove that nanosize colloidal silver was not noxious to the skin by calculating the primary irritation index (P.I.I.) [2,12].…”

mentioning

confidence: 99%

Bacteriostasis and Skin Innoxiousness of Nanosize Silver Colloids on Textile Fabrics

Lee

Jeong

2005

Textile Research Journal

173

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This research deals with the bacteriostasis and the skin-innoxiousness of a nanosize silver colloidal solution used as an agent for the antibacterial treatment of textile fabrics. We placed nanosize silver colloidal solutions and the textile fabrics treated with the same solutions on germ-containing agar plates, respectively, and calculated the bacterial reduction after certain contact times to evaluate the antibacterial efficacy of nanosilver in colloidal solutions and textile fabrics. The antibacterial treatment of textile fabrics was easily achieved by using nanosize silver colloidal solution. The result of skin-irritation testing of a nanosilver colloidal solution showed the skin-innoxiousness of nanosilver to animals. The TEM observation of silver nanoparticles showed their shape and size distribution. The SEM image of the treated fabric indicated silver nanoparticles were well dispersed on the fabric surface.

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mentioning

confidence: 99%

Bacteriostasis and Skin Innoxiousness of Nanosize Silver Colloids on Textile Fabrics

Lee

Jeong

2005

Textile Research Journal

173

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“…This is not surprising since it has long been recognized that surfactants ('soaps') are consistent skin irritants. One such compound, sodium lauryl sulfate, is actually a standard positive agent for commercial skin irritancy studies (12). The finding that local dilution with normal saline or hyaluronidase significantly lessens VP-16 ulceration argues strongly for a concentration-dependent type of epipodophyllotoxin solvent toxicity.…”

Section: Discussionmentioning

confidence: 98%

Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents

Dorr

Alberts

1983

Invest New Drugs

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The epipodophyllotoxin derivatives, etoposide (VP-16) and teniposide (VM-26), are highly lipophilic anticancer drugs supplied with novel commercial solvent systems. A BALB/c mouse skin toxicity model was used to evaluate the ulcerative potential of intradermal (ID) VP-16 and its lipophilic solvent system along with the main ingredient of the VM-26 solvent, polyethoxylated castor oil (PECO). ID VP-16 caused dose-dependent ulceration following 0.17 mg, 0.33 mg (50 mg/M2) or 1.0 mg (150 mg/M2). Both normal saline (0.05 ml ID) and hyaluronidase (7.5 u ID) were effective as local VP-16 antidotes, presumably by diluting out the extravasated drug. The VP-16 solvent alone was as toxic as the 1.0 mg (undiluted) ID VP-16 injection. ID PECO was mildly ulcerative in mouse skin. When given to P-388 lymphocytic leukemia-bearing mice, both VP-16 (24 mg/kg IP for 3 doses) and VM-26 (8 mg/kg IP for 2 doses) were active, producing increased life spans (ILS) of 160% and 90%, respectively. The solvents, given IP at the same schedule, did not increase or decrease the life span of tumor-bearing mice, but did increase morbidity. In an in vitro human tumor clonogenic assay (WiDr colon carcinoma and HEC-1A endometrial carcinoma in soft agar), both VP-16 and VM-26 showed moderate to complete inhibition of tumor colony forming units (TCFUs) by continuous exposure. 1-h drug exposures were marginally active at reducing TCFUs. None of the epipodophyllotoxin diluents at clinical concentrations reduced TCFUs. At very high concentrations, both epipodophyllotoxins were cytotoxic. They were more effective at reducing TCFUs when plated as a continuous exposure rather than a 1-h exposure.

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“…Radiolabeled tracers or biochemical techniques to monitor skin healing is also utilized by some investigators. Other investigators supplement with histological evaluation of skin tissue (Mezei et al, 1966;Murphy et al, 1979).…”

Section: Animal Testing (Draize Rabbit Test)mentioning

confidence: 99%

Skin Irritation Caused by Alcohol-Based Hand Rubs

Yamamoto¹

2012

Infection Control - Updates

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Cutaneous irritation in the topical application of 30 antineoplastic agents to New Zealand white rabbits

Cited by 11 publications

References 16 publications

Bacteriostasis and Skin Innoxiousness of Nanosize Silver Colloids on Textile Fabrics

Bacteriostasis and Skin Innoxiousness of Nanosize Silver Colloids on Textile Fabrics

Skin ulceration potential without therapeutic anticancer activity for epipodophyllotoxin commercial diluents

Skin Irritation Caused by Alcohol-Based Hand Rubs

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