The pure carboxylated catechoyl amide LICAM(C) and the calcium and zinc salts of diethylenetriaminepenta-acetic acid (DTPA), were tested for efficacy for removing 238Pu and 241Am from rats after inhalation of the nitrate or intravenous injection of the citrate. The results were compared with the efficacy of methylated LICAM(C) used in previous experiments. It was shown that: (1) after inhalation of 238Pu nitrate, DTPA was far superior to pure LICAM(C); (2) after intravenous injection of 238Pu citrate, the infusion of DTPA plus LICAM(C) was only marginally more effective than DTPA alone; and (3) after inhalation or intravenous injection of 238Pu plus 241Am, the efficacy of pure LICAM(C) was only marginally more effective than the methylated form and neither form was effective for the decorporation of 241Am. It was concluded that DTPA, at present, remains the chelating agent of choice for treating persons accidentally contaminated with transportable forms of Pu and Am.

No abstract

A procedure was developed for screening of cannabinoids for their ability to reduce intraocular pressure (lOP) using normal rabbits.

In dogs, the major metabolite of phencyclidine was found to be 5-[IV-(1 '-phenylcyclohexyl)amino]pentanoic acid (1). The -aminobutyric acid like metabolite was also pharmacologically evaluated to determine if the purported GABA-ergic mediated effects of phencyclidine on locomotor activity might be attributed to the metabolite. Preliminary pharmacological evaluation of 1 and its methyl ester indicates that the metabolite has little, if any, association with the effect of phencyclidine on locomotor activity.

No abstract