Cutaneous Lymphocyte Antigen Is a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma

Peru, Sara; Prochazkova-Carlotti, Martina; Cherrier, Floriane; Velazquez, Joanne; Richard, Élodie; Idrissi, Yamina; Cappellen, David; Azzi-Martin, Lamia; Pham‐Ledard, Anne; Beylot‐Barry, M.; Merlio, Jean-Philippe; Poglio, Sandrine

doi:10.1016/j.jid.2022.06.016

Cited by 7 publications

(8 citation statements)

References 36 publications

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“…As such, antibodytargeting of CLA inhibits trans-endothelial migration of T cells. 22,23 CD69 is a transmembrane C-Type lectin rapidly up-regulated upon TCR stimulation and regarded as an early activation marker for T lymphocytes. 24 CD69 forms a complex with S1PR1, counteracting S1P-S1PR1 interaction, which normally attracts T cells from lymphoid organs back to the circulation via a S1P gradient in the bloodstream.…”

Section: T Rm Composition and Phenotype In Adult Skinmentioning

confidence: 99%

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Functional heterogeneity of human skin‐resident memory T cells in health and disease

Strobl

Haniffa

2023

Immunological Reviews

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Summary The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue‐resident memory T cells (TRM) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with TRM properties is also known to contribute to cutaneous T‐cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin TRM. We summarize recent studies on TRM formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin TRM and their role in maintaining skin homeostasis and altered functions in skin disease.

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Section: T Rm Composition and Phenotype In Adult Skinmentioning

confidence: 99%

“…CLA is a carbohydrate modification of P‐selectin glycoprotein ligand‐1 and is a functional ligand for both cell adhesion molecules E‐selectin and P‐selectin 16 and regulates T‐cell homing to skin. As such, antibody‐targeting of CLA inhibits trans‐endothelial migration of T cells 22,23 …”

Section: Generation Maintenance and Longevity Of Skin Trmmentioning

confidence: 99%

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Strobl

Haniffa

2023

Immunological Reviews

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“…to correlate with the clinical activity and response to treatment of cutaneous diseases (Table 2). 26 For instance, in cutaneous T-cell lymphoma, CLA is expressed on tumorigenic CCR4 + CD4 + T cells 48 ;…”

Section: Salt 44 Properties Cla + T Cells Propertiesmentioning

confidence: 99%

“…In this sense, circulating CLA + T cells respond to antigens, allergens, viruses, bacterial superantigens and drugs, and their phenotype has been reported to correlate with the clinical activity and response to treatment of cutaneous diseases (Table 2). 26 For instance, in cutaneous T‐cell lymphoma, CLA is expressed on tumorigenic CCR4 + CD4 + T cells 48 ; in dengue, CLA is upregulated in virus‐specific effector CD4 + and CD8 + T cell populations the day before defervescence 59 ; in herpes simplex, CLA is selectively expressed on circulating virus‐specific CD8 + T cells, which are involved in viral clearance in the skin 51 ; in papuloerythroderma, circulating CD4 + and CD8 + T cells preferentially express the CLA marker and produce IL‐4, IL‐13, IL‐22 and IL‐31, that decrease after clinical remission 55 ; and in plaque psoriasis, the response to Streptococcus pyogenes is confined to CLA + T cells with an IL‐17 response that correlates with the clinical status of the patients 56 …”

Section: Cla Expression On Human T Cells and Skinmentioning

confidence: 99%

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CLA⁺ memory T cells in atopic dermatitis

Nicolàs

Czarnowicki

Akdiş

et al. 2023

Allergy

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Circulating skin‐homing cutaneous lymphocyte‐associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL‐13, IL‐31, pruritus, CCL17 and early effects on dupilumab‐treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin‐associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.

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Antibody targeting of surface P‐selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

Pereira,

Ferreira,

dos Santos

2024

Hematological Oncology

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Lymphomas are a heterogeneous group of diseases that originate from T, B or natural killer cells. Lymphoma treatment is based on chemotherapy, radiotherapy, and monoclonal antibody (mAb) or other immunotherapies. The P‐selectin glycoprotein ligand 1 (PSGL‐1) is expressed at the surface of hematological malignant cells and has been shown to have a pro‐oncogenic role in multiple myeloma and lymphoma. Here, we investigated the expression and therapeutic potential of PSGL‐1 in T and B cell lymphomas. By flow cytometry analysis, we found that PSGL‐1 was expressed in both T and B cell‐derived lymphoma cell lines but generally at higher levels in T cell lymphoma cell lines. For most T and B cell‐derived lymphoma cell lines, in vitro targeting with the PL1 mAb, which recognizes the PSGL‐1 N‐terminal extracellular region and blocks functional interactions with selectins, resulted in reduced cell viability. The PL1 mAb pro‐apoptotic activity was shown to be dose‐dependent, to be linked to increased ERK kinase phosphorylation, and to be dependent on the MAP kinase signaling pathway. Importantly, anti‐PSGL‐1 treatment of mice xenografted with the HUT‐78 cutaneous T‐cell lymphoma cell line resulted in decreased tumor growth, had no effect on in vivo proliferation, but increased the levels of apoptosis in tumors. Anti‐PSGL‐1 treatment of mice xenografted with a Burkitt lymphoma cell line that was resistant to anti‐PSGL‐1 treatment in vitro, had no impact on tumorigenesis. These findings show that PSGL‐1 antibody targeting triggers lymphoma cell apoptosis and substantiates PSGL‐1 as a potential target for lymphoma therapy.

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Cutaneous Lymphocyte Antigen Is a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma

Cited by 7 publications

References 36 publications

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Functional heterogeneity of human skin‐resident memory T cells in health and disease

CLA⁺ memory T cells in atopic dermatitis

Antibody targeting of surface P‐selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

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Cutaneous Lymphocyte Antigen Is a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma

Cited by 7 publications

References 36 publications

Functional heterogeneity of human skin‐resident memory T cells in health and disease

Functional heterogeneity of human skin‐resident memory T cells in health and disease

CLA+ memory T cells in atopic dermatitis

Antibody targeting of surface P‐selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

Contact Info

Product

Resources

About

CLA⁺ memory T cells in atopic dermatitis