Cutaneous Malignant Lymphoma in an Infant

Umebayashi, Yoshihiro; Nameki, Hiromasa; Saito, Yoshio; Mori, Naoyoshi

doi:10.1111/j.1346-8138.1990.tb03025.x

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…In contrast, apart from a few reports describing the spectrum and fate of primary cutaneous lymphomas (pB‐cell LBL, ALCL) in infancy and childhood, investigational studies in infant NHL are lacking (Grümayer et al , 1988; Umebayashi et al , 1990; Varan et al , 2005). In addition, although NHL is a well known complication in children having an underlying defect in their immune system, a previous report of our study group registered only one infant (patient 3 of the present analysis) with NHL among 19 patients with a primary immunodeficiency (Seidemann et al , 1999).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and treatment outcome of infants with non‐Hodgkin lymphoma

et al. 2007

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Summary Non‐Hodgkin lymphoma (NHL) is rarely observed during infancy and data on its incidence, characteristics and outcome are scarce. The present study aimed to assess the prevalence, clinical presentation and treatment results of all infants who were diagnosed with NHL between October 1986 and December 2002 among 2084 patients treated according to the NHL‐BFM (Berlin‐Frankfurt‐Münster) multicentre trials 86, 90 and 95. We identified 20 (1%) infants with NHL including five with T‐cell lymphoblastic lymphoma (T‐cell LBL), seven with precursor B‐cell LBL (pB‐cell LBL), two with a mature Burkitt neoplasm, five with anaplastic large cell lymphoma (ALCL) and one with peripheral T‐cell lymphoma (PTCL). The PTCL patient, 3/7 pB‐cell LBL and 1/5 ALCL patients relapsed. One patient each from the T‐cell LBL and Burkitt lymphoma groups suffered from a second malignancy and one patient each with ALCL and Burkitt leukaemia died from treatment‐related toxicity. The 5‐year event‐free survival rate was 53 ± 12% for the 20 cases. This study has provided preliminary evidence that infants with NHL have a dismal prognosis and showed that infant NHL differed to lymphomas in older patients with respect to the distribution of gender, histopathologic subtypes as well as the ratio of T‐ to pB‐cell LBL and the frequency of relapses of pB‐cell LBL.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and treatment outcome of infants with non‐Hodgkin lymphoma

et al. 2007

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Characterization of a CD34+ cell line established from a child with large cell cutaneous lymphoma

Lorenzana

McCabe

Goodell

et al. 1993

Cancer

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Background. Lymphoma presenting with skin involvement has heterogeneous morphology and rarely is seen in children. To study the pathogenesis of this disease, lymphoma cells from a child with B‐cell large cell lymphoma of the skin were cultured in vitro. Methods. Lymphoma cells cultured on a feeder layer under hypoxic conditions grew in vitro after a latency period of 2 weeks. Since interleukin‐6 (IL‐6) induces final differentiation of activated B‐lymphocytes, the cell line was evaluated for the presence of IL‐6 receptors and biologic response to IL‐6. Results. An Epstein–Barr virus (EBV)‐negative cell line (UoC‐B2) was established which expressed CD34, CD45, HLA‐DR, CD19, CD20, sIgM, sIgD, and lambda light chain. Good general concordance was observed between the patient's lymphoma and the cell line by comparing the immunophenotype, genotype, and karyotype. The UoC‐B2 cells expressed surface IgM but did not secrete IgM into the culture media even in the presence of supplemental IL‐6. Conclusions. A B‐lymphoid cell line (UoC‐B2) was established from a child with primary cutaneous lymphoma. The cells expressed cell surface IgM and receptors for IL‐6 but supplemental IL‐6 had no effect on IgM production or cell proliferation.

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Kutane Lymphome

Dippel

Klemke²,

Goerdt³

Pädiatrische Dermatologie

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Cutaneous Malignant Lymphoma in an Infant

Cited by 3 publications

References 7 publications

Clinical characteristics and treatment outcome of infants with non‐Hodgkin lymphoma

Clinical characteristics and treatment outcome of infants with non‐Hodgkin lymphoma

Characterization of a CD34+ cell line established from a child with large cell cutaneous lymphoma

Kutane Lymphome

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