Cutaneous Malignant Melanoma in a Black Patient with Neurofibromatosis (von Recklinghausenʼs Disease)

Jf, Silverman; Blahove, M; Jl, Collins; Ht, Norris

doi:10.1097/00000372-198812000-00011

Cited by 19 publications

(6 citation statements)

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“…In their 1972 study Brasfield and Das Gupta" found six cases (5.4%) of melanoma in 110 patients with neurofibromatosis, three of which developed within large congenital nevi. Other authors have presented single cases, including an anorectal melanoma16, 20,29,33,40,44. The association of NF-l with uveal melanoma, reported by numerous authors, is better known 2 ,5,12,13,21,37,38,45,47,48,52.54 . In these patients the melanoma seems to have arisen within preexisting uveal nevi-".…”

Section: Discussionmentioning

confidence: 96%

Association between Cutaneous Melanoma and Neurofibromatosis Type 1: Analysis of Three Clinical Cases and Review of the Literature

Gallino¹,

Belli

Tragni

et al. 2000

Tumori

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The authors report a rare association between cutaneous melanoma and Von Recklinghausen's disease (NF-1) and analyze the possible meaning of this occurrence. Various types of tumors have been associated with NF-1, in particular those of neuroectodermal origin, such as malignant peripheral nerve sheath tumors (MPNST) and phaeochromocytoma. The development of malignant melanoma in NF-1 patients is rare. Data from the literature is enable to demonstrate an increased incidence of cutaneous melanoma in patients with neurofibromatosis but the association of these two disorders seems reasonable in theory, as both are abnormalities of a neural crest origin. The cases described may represent not only a clinical report of two rarely associated disorders, but may also confirm the biological mechanisms responsible for these infrequent diseases.

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Section: Discussionmentioning

confidence: 96%

Association between Cutaneous Melanoma and Neurofibromatosis Type 1: Analysis of Three Clinical Cases and Review of the Literature

Gallino¹,

Belli

Tragni

et al. 2000

Tumori

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“…A possible explanation for this higher Breslow thickness might be a delay in diagnosis because of the difficulty of identifying the malignant melanoma amongst the various skin lesions and hyperpigmentations seen in NF1. In a number of cases the cutaneous melanoma developed in giant congenital nevi (Brasfield & Das Gupta, 1972; Hope & Mulvihill, 1981), café‐au‐lait spots (Perkinson, 1957), sunburned skin, nevus spilus (Rütten & Goos, 1990) or in skin overlying a neurofibroma (Silverman et al., 1988).…”

Section: Malignant Melanoma In Nf1: a Mere Coincidence?mentioning

confidence: 99%

Pigment cell‐related manifestations in neurofibromatosis type 1: an overview

Schepper

Boucneau

Lambert

et al. 2005

Pigment Cell Research

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SummaryNeurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder, affecting approximately 1 in 3500 individuals. The most commonly seen tumors in NF1 patients are the (sub)cutaneous neurofibromas. However, individuals with NF1 typically present in childhood with welldefined pigmentary defects, including café -au-lait macules (CALMs), intertriginous freckling and iris Lisch nodules. NF1 is considered a neurocristopathy, primarily affecting tissues derived from the neural crest. Since the pigment producing melanocyte originates in the neural crest, the presence of (hyper)pigmentary lesions in the NF1 phenotype because of changes in melanocyte cell growth and differentiation is to be expected. We want to discuss the pigmentary cutaneous manifestations of NF1 represented by CALMs and intertriginous freckles and the pigmentary non-cutaneous manifestations represented by iris Lisch nodules. Several hypotheses have been suggested in explaining the poorly understood etiopathogenesis of CALMs. Whether other pigmentary manifestations might share similar etiopathogenic mechanisms remains obscure. Additional attention will be drawn to a readily seen phenomenon in NF1: hyperpigmentation overlying (plexiform) neurofibromas, which could suggest common etiopathogenetic-environmental cues or mechanisms underlying CALMs and neurofibromas. Finally, we want to address the relationship between malignant melanoma and NF1.

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“…They reported a 64‐year‐old man with hundreds of cutaneous and subcutaneous neurofibromas covering the trunk and extremities. A melanoma was discovered above a polypoid lesion not previously marked as a café‐au‐lait spot 11 . In addition, only one case, reported by Perkinson, described a melanoma arising in a café‐au‐lait spot of neurofibromatosis after a severe sunburn 12 .…”

Section: Discussionmentioning

confidence: 99%

Dysplastic nevi with an underlying or juxtaposed neurofibroma: does a relationship exist?

Maize¹,

Burch²

2007

J Cutan Pathol

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Cutaneous Malignant Melanoma in a Black Patient with Neurofibromatosis (von Recklinghausenʼs Disease)

Cited by 19 publications

References 0 publications

Association between Cutaneous Melanoma and Neurofibromatosis Type 1: Analysis of Three Clinical Cases and Review of the Literature

Association between Cutaneous Melanoma and Neurofibromatosis Type 1: Analysis of Three Clinical Cases and Review of the Literature

Pigment cell‐related manifestations in neurofibromatosis type 1: an overview

Dysplastic nevi with an underlying or juxtaposed neurofibroma: does a relationship exist?

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