Cutaneous Manifestations of Diabetes Mellitus

Duff, Michelle; Демидова, Ольга Михайловна; Blackburn, Stephanie; Shubrook, Jay H.

doi:10.2337/diaclin.33.1.40

Cited by 120 publications

(111 citation statements)

References 59 publications

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“…This eponym is based on the 2.5% prevalence of indurated plaques in poorly controlled adult diabetics 11, 12, 13, 14. Pathogenesis of scleredema diabeticorum involves increased collagen glycosylation resulting in excess cross-linking, rendering fibers resistant to degradation and ultimately increasing dermal thickness 15 . Histopathology shows abnormal mucin accumulation in the reticular dermis and dermal collagen fiber sclerosis.…”

Section: Introductionmentioning

confidence: 99%

Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke

Skrepnik

Gottesman

Stea

2016

Advances in Radiation Oncology

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IntroductionScleredema of Buschke is a rare connective tissue disorder presenting with woody thickening and induration of the nuchal and shoulder regions resulting in progressive decrease in the range of motion of the neck. Treatment options include several forms of systemic therapy with variable results. Local radiation therapy (RT) is often thought of as a secondary form of therapy. Few reports exist in the literature about the durability of its benefit, however. Here, we present a case report with the longest known follow-up after primary treatment with electron beam RT.MethodsThe patient was treated using 8-MeV en face electrons with 2000 cGy in 10 fractions with 2 separate but matched electron fields. The treatment fields included the posterior neck from the occiput superiorly to the mid-thoracic spine inferiorly with the lateral borders extending to the scapulae. The patient received no additional therapy either pre- or post-RT. Clinical follow-up was obtained at regular intervals. Published literature regarding RT for this disease was reviewed and consolidated.ResultsThe patient was followed at regular intervals for 6 years with significant softening of the plaque starting at 2 months after RT, resulting in decrease in plaque size by 50% after 18 months. The patient regained 45° of lateral, bidirectional cervical motion from central axis and 50% improvement in neck extension that has remained durable 6 years after treatment with no additional therapy. Quality of life was restored with a simple nontoxic treatment limited to transient, grade 1 fatigue.ConclusionScleredema of Buschke is a rare connective tissue disorder commonly treated with multimodal therapy, but it can be effectively and durably controlled with RT alone. This case report documents the durability of the benefit achieved with RT and suggests that RT should be considered earlier in the treatment of this disease.

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Section: Introductionmentioning

confidence: 99%

Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke

Skrepnik

Gottesman

Stea

2016

Advances in Radiation Oncology

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“…The hallmark finding in this study suggested an active role of S. aureus and its superantigens in the progression to type-2 diabetes [23]. Staphylococcal folliculitis or skin abscesses are counted as the most common bacterial infections in uncontrolled diabetes [24]. Acute otitis externa: Invasive ("malignant") otitis externa is a quite rare but potentially fatal infection of the external auditory canal and skull.…”

Section: Staphylococcal Infectionsmentioning

confidence: 85%

Skin Infections in Diabetes: A Review

AK¹,

Bhatt²

2016

J Diabetes Metab

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Diabetes mellitus (DM) constitutes a growing concern to world population due to the devastating effects of its chronic complications. An estimated number of people with diabetes are projected to rise from 171 million in 2000 to 366 million in 2030. Glucose intolerance is the intermediate stage between normal glucose tolerance and diabetes. It results in ketoacidosis and hyperglycemia causing immune dysfunction. Patients with diabetes mellitus are therefore predisposed to cutaneous infections. If remain unnoticed, undiagnosed in the early stages or not treated properly such infections may get complicated and can even prove lethal. It therefore becomes imperative to recognize signs and symptoms of such infections and approach them appropriately or refer the patient to a diabetologist or dermatologist. Our review literature is a comprehensive communication involving several cutaneous infections that manifest more frequently, with greater severity; or with an elevated risk for complications in patients with diabetes mellitus.

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“…Correlation with nephropathy and other microangiopathic complications is also seen with rubeosis facei diabeticorum. This disorder presents in approximately 3–5% of diabetics as facial redness and is a frequently overlooked microangiopathic condition [10]. Necrobiosis lipopidica diabeticorum, while rare, is a clinically distinctive disorder that has been associated with diabetes mellitus.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

“…Among these disorders are acanthosis nigricans, diabetic dermopathy, scleredema diabeticorum, necrobiosis lipoidica diabeticorum, rubeosis faceii, bullosis diabeticorum, and perforating disorders. Cutaneous infections, psoriasis, eruptive xanthoma and multiple acrochordons are also common in diabetics [10]. …”

Section: Diabetes Mellitusmentioning

confidence: 99%

Skin Examination: An Important Diagnostic Tool in Renal Failure Patients

Velde-Kossmann¹

2018

Blood Purif

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Renal failure is common in the United States with an estimated prevalence of 660,000 treated end-stage renal disease patients in 2015 [1]. Causes of renal failure are many, and complications from renal failure, underlying disease, and treatment are not infrequent. Examples of common skin manifestations include xerosis, pigmentary change, and nail dystrophies. Frequent disease-specific skin changes may be helpful in the diagnosis of primary disorders leading to renal disease or severity of disease including bullosis diabeticorum, sclerodactyly, or leukoctoclastic vasculitis. Some cutaneous changes, such as the multiple angiokeratomas of Fabry disease or the plexiform neurofibromas of neurofibromatosis, are pathognomonic of genetic disorders, which often lead to renal failure. Careful examination of the skin can provide crucial clues to diagnosis of renal failure causation and aid in monitoring complications.

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Cutaneous Manifestations of Diabetes Mellitus

Cited by 120 publications

References 59 publications

Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke

Long-term benefit of electron beam radiation therapy in the treatment of scleredema of Buschke

Skin Infections in Diabetes: A Review

Skin Examination: An Important Diagnostic Tool in Renal Failure Patients

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