Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Khalesi, Mohammad; Whiteman, David C.; Doi, Suhail A.R.; Clark, Justin; Kimlin, Michael G.; Neale, Rachel E.

doi:10.1158/1055-9965.epi-13-0424

Cited by 39 publications

(42 citation statements)

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“…In addition, most SCC lesions arise from actinically damaged skin, which is an indicator of cumulative (lifetime) UVR exposure [2]. On the contrary, an association between morphologic markers of cutaneous photodamage and an increased risk of BCC has been proven to be only moderate [19].…”

Section: Kľúčové Slovámentioning

confidence: 99%

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Bartoš¹,

Kullová²

2018

Klin Onkol

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SummaryBackground: Non-melanoma skin cancer (NMSC) is the most common malignancy in Caucasians. It mainly includes two major keratinocyte tumors -basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The objective of the study was to analyze and compare the clinicopathological differences between patients with BCC and SCC of the skin. Material and Methods: A cohort of 541 patients with a total of 719 BCCs, and 126 patients with a total of 162 SCCs were retrospectively analyzed. Results: While there was virtually the same proportion of men (49.91%) and women (50.09%) in BCC patients, SCCs occurred more frequently in men (68.2%) than in women (31.8%). The mean age of the individuals with BCC and SCC was 70.8 and 78.2 years, resp. The number of BCCs rises from 50 years of age and this increase showed a linear trend up to 80 years, subsequently followed by decline. SCC lesions occur more rapidly from 70 years of age followed by a sharp increase that exhibited an exponential relationship. BCCs and SCCs occurred predominantly on the head and neck region, compris ing a total of 69.8% and 81.4% of the cases, resp. However, BCC lesions were seen more often on the face and SCC lesions were dia gnosed more frequently on the extra-facial parts of the head. Further, BCCs occurred more frequently on the trunk, and particularly on the back, compared to SCCs. Conclusion: Although BCC and SCC are covered under common term NMSC, they manifest several clinicopathological differences. Despite shar ing common etiologic determinants, at least from the onco-epidemiologic perspective, they should be considered separately.

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Section: Kľúčové Slovámentioning

confidence: 99%

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Bartoš¹,

Kullová²

2018

Klin Onkol

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“…As shown by Green et al [29], the relative risk of developing invasive SCC is increased by 5–6 times, if up to 20 AKs are present. The risk for developing a BCC is increased by up to 5 times if AK count exceeds 10 [7]. …”

Section: Discussion/conclusionmentioning

confidence: 99%

“…Both AK and BCC share a substantial amount of environmental and individual risk factors including ultraviolet radiation, fair skin, low ability to tan, higher age, male sex, personal or family history of skin cancer and immunosuppression [1, 3, 5, 6]. Both are markers of cutaneous photodamage and the presence of AK and BCC in a single individual is not uncommon; moreover, the presence of AK has been shown to increase the risk of BCC by approximately 3 times [7]. …”

Section: Introductionmentioning

confidence: 99%

Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review

et al. 2019

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Chronic exposure to ultraviolet radiation induces gradual changes in cutaneous morphology, which with increasing damage leads to the appearance of cancerous skin lesions. Among them, basal cell carcinomas (BCCs) and actinic keratoses (AKs) are the most common entities. Both lesions often develop as two separate lesions in a single individual at a conspicuous distance, close proximity or as collision lesions, which are characterized by the coexistence of both cancers in the same anatomical site. Collision lesions in which AK precisely overlies BCC is a rarely reported entity. We report a case where the presence of BCC was dermatoscopically detected after an overlying AK was treated with topical chemotherapy, thus indicating that treatment of AK allows better visualization of other underlying malignancies.

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“…Popular belief is that a crucial factor for the formation of SCC is cumulative lifetime sun exposure, while it is less important for the development of BCC, in which an intermittent solar exposure rather than chronic one may be more prejudicial etiologic determinant [1,[18][19][20]. Even association between morphologic markers of cutaneous photodamage and an increased risk of BCC has been proven only moderate [21]. As for cutaneous MM, an intermittent intense sun exposure was shown to play considerable role as risk factor, whereas a high occupational sun exposure seemed to be inversely associated to MM development [1,18,20,[22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

Barto¹,

Kullová²

2017

J Environ Occup Sci

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INTRODUCTIONHuman skin cancers encompass a wide spectrum of malignant conditions with different epidemiologic and clinical characteristics. The three most common malignancies include basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), also referred to, collectively, as nonmelanoma skin cancer (NMSC), and malignant melanoma (MM). Although their etiopatogenesis is complex, there is persuasive evidence that an ultraviolet radiation (UVR) has a vital role in the development of each of these main tumor types [1]. However, the relative relationship between the sunlight exposure and the genesis of BCC, SCC, and MM seems to be tumor-specific [1]. These UVR-related differences result in distinct anatomic distribution of the skin cancer types. In general, while MMs arise most commonly on the trunk and limbs [2][3][4][5][6][7], the vast majority of research papers have clearly demonstrated [3,[7][8][9][10][11][12][13] that NMSC occurs predominantly on the head and neck region. In spite of that, however, some studies [4,5,[14][15][16] have found discrepant percentages of BCCs and SCCs at individual body parts compared with the above-mentioned papers and as a consequence, the relative tumor density (RTD) has showed wide variations. The RTD measure was first introduced by Pearl and Scott [17] in 1986, to create a standard way of comparing skin cancers distribution by anatomical sites. It considers the ratio between the proportion of tumor in a certain location and the proportion of the surface area on the same location. This index highlights the differences between the expected and observed occurrence of tumors by site. In this study, we have evaluated the topographic distribution and RTD of three types of cutaneous neoplasms mentioned above and confronted our results with eligible literature data. Results: MMs occurred most commonly on the trunk (46.8%) and the upper limbs (25.3%). While the back and the trunk in particular was sites with the most frequent MM development in males (64.3% and 45.9%), the upper limbs were the most common location in females (34.1%). BCCs and SCCs occurred predominantly on the head and neck, comprising a total of 69.0% and 81.5% of the cases. The face was a region with by far the highest RTDs in BCC and SCC patients. Men had more frequently affected extrafacial sites of the head and neck compared to women in both BCC (46% vs. 31.9%) and SCC (62.5% vs. 48.3%) cases. In BCC, the second most frequent anatomic site included the back in both genders (25.1% in males, 18.2% in females), but in SCC, it represented the trunk as a whole in males (13.6%), and the lower limbs in females (14.3%). The greatest differences in RTDs between BCC and SCC were on the back (BCC: SCC ratio, 7.5:1), especially in men (BCC: SCC ratio, 9:1). Conclusion: We have confirmed striking heterogeneity for skin cancer risk by anatomic site. While MMs arise predominantly on the body parts intermittently exposed to the sunlight, BCCs and especially SCCs develop most frequently on the sites that are habitually exposed to ...

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Cutaneous Markers of Photo-Damage and Risk of Basal Cell Carcinoma of the Skin: A Meta-Analysis

Cited by 39 publications

References 50 publications

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Non-melanoma Skin Cancer – a Clinicopathological Study of Patients with Basal Cell Carcinoma and Squamous Cell Carcinoma

Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review

Body Site Distribution and Relative Tumor Density of Different Human Cutaneous Malignancies with Emphasis on Sunlight Exposure: A Single Institution Experience

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