Cutaneous melanoma in relation to intermittent and constant sun exposure—the western canada melanoma study

Elwood, J. Mark; Gallagher, Richard P.; Hill, Gerry B.; Pearson, Jennifer

doi:10.1002/ijc.2910350403

Cited by 277 publications

(169 citation statements)

References 16 publications

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“…A maior parte das capitais brasileiras encontra-se perto do litoral, e as diversas situações de exposição (lazer, trabalho, atividade doméstica) podem ter influências importantes nos níveis de exposição solar cumulativos 11 . Conseqüente-mente, ao juntarmos diversas capitais por região, podemos estar juntando cidades com características diferentes de situação de exposição solar (por exemplo, capitais localizadas perto do litoral e no interior).…”

Section: Discussionunclassified

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Comportamento relativo à exposição e proteção solar na população de 15 anos ou mais de 15 capitais brasileiras e Distrito Federal, 2002-2003

et al. 2007

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Este artigo explora a relação entre variáveis sócio-demográficas e comportamentais com proteção solar, levando-se em consideração as diferenças regionais existentes. Um inquérito de base populacional foi realizado em 15 capitais brasileiras e Distrito Federal, e as informações sobre exposição solar foram coletadas para um total de 16.999 indivíduos de 15 anos ou mais. Quando comparamos os indivíduos residentes nas regiões Norte e Sul do país, as diferenças brutas entre mulheres e homens nas proporções de utilização do protetor solar e do chapéu foram, respectivamente, para a Região Norte, +10,9% (IC95%: 7,1; 14,6) e -11,6% (IC95%: -17,0; -6,3), e Sul do país, +21,3% (IC95%: 17,7; 24,9) e -16,0% (IC95%: -20,2; -12,5). As diferenças ajustadas confirmaram que, tanto no Norte quanto no Sul do país, as mulheres mais freqüentemente utilizaram como proteção o filtro solar e menos freqüentemente referiram o uso de chapéu do que os homens. Contudo, essas diferenças não foram homogêneas entre as re- giões (termos de interação p < 0,05).

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Section: Discussionunclassified

“…Associadas a esses hábitos de vida e proteção, distinguem-se três situações de exposição solar: no lazer, no trabalho e na realização de atividades domésticas 10,11 .…”

Section: Introductionunclassified

Comportamento relativo à exposição e proteção solar na população de 15 anos ou mais de 15 capitais brasileiras e Distrito Federal, 2002-2003

et al. 2007

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“…Epidemiological studies have revealed a correlation between exposure to sunlight and the development of cutaneous melanoma, especially of the lentigo maligna type but also of the more common types studied here (5)(6)(7)(8)19). This finding suggests that UV irradiation damages the DNA of melanocytes that might contribute to the development of neoplasia.…”

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confidence: 94%

“…We therefore investigated the precise sites of the tumors on the bodies of melanoma patients with respect to sun exposure. Exposure was categorized as continuous, intermittent, or rare (5)(6)(7)(8)18; see footnote c, Table 1). For 31 of the patients, localization of the primary tumor was indicated in the clinical record: in 10 patients on continuously exposed sites, in 16 on intermittently exposed sites, and in 5 on rarely exposed sites (Table 1).…”

mentioning

confidence: 99%

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

Veer¹,

Burgering²,

Versteeg³

et al. 1989

Mol. Cell. Biol.

249

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In 7 of 37 patients with cutaneous melanoma, mutations in the N-ras gene were found. The primary tumors of these seven patients were exclusively localized on body sites continuously exposed to sunlight. Moreover, the ras mutations were all at or near dipyrimidine sites known to be targets of UV damage. Two primary tumors were biclonal with respect to ras mutation. An active role for UV irradiation in induction of the mutations is suggested.In animals, a wide range of xenobiotic agents are capable of inducing mutations in the r-as oncogene family (2). Little is known, however, about the involvement of mutagenic agents in the induction of ras mutations in humans. For human cutaneous melanoma, there is epidemiological evidence suggesting a role of UV irradiation in occurrence of the tumor (18).N-ras activated in melanoma. To investigate the role of UV irradiation in the activation of ras genes, we studied 63 tumor samples from 37 cutaneous melanoma patients (Table 1) for mutations in H-, K-, or N-r-as. These samples included 10 primary tumors, 40 metastases, and 13 cell lines, all of the non-lentigo maligna type. To analyze mutational activation of ras genes, polymerase chain reaction-amplified DNA samples were prepared aR described previously (17) either from DNA obtained from fresh tumor specimens and cell lines or from Formalin-fixed and paraffin-embedded material (16). All samples contained at least 50% tumor cells. In certain cases (e.g., primary tumors of patients 4 and 10), parts of paraffin sections that contained more than 90% tumor cells were chosen. The amplified DNA was spotted onto nylon membranes and hybridized to probes 20 nucleotides long as described elsewhere (21) (Fig.

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“…We selected melanocytic tumors for our study because of the close connection between melanoma etiology and ultraviolet exposure (15)(16)(17)(18)(19)(20).…”

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confidence: 99%

Differential Expression of DNA Nonhomologous End-Joining Proteins Ku70 and Ku80 in Melanoma Progression

et al. 2002

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Ku70 and Ku80 heterodimers function as regulatory subunits of the DNA-dependent protein kinase and play a very important role in the repairing of DNA double-strand breaks. Although Ku70 is proposed as a candidate for a tumor suppressor gene, not many data are available on Ku70 and Ku80 expression in human tumors. The main aim of this study was to investigate the expression of Ku70 and Ku80 in the ultravioletinduced lesions-nevus cell nevi, lentigos maligna, and malignant melanomas. Nineteen nevus cell nevi, 23 lentigos maligna, 76 primary melanomas, and 31 melanoma metastases were stained immunohistochemically for the presence of Ku70 and Ku80 proteins. Ku70 and Ku80 expression was preserved in about 80% of nevi, 26% of lentigo maligna, 45% of primary melanomas, and 67% of melanoma metastases. Highly significant differences in Ku70 and Ku80 expression were found between nevi, lentigo maligna, and melanomas. In Cox regression, Ku70 and Ku80 were shown to be highly significant influences on patients' prognosis. Significant correlations between Ku70 and Ku80 expressions were found in nevi, lentigo maligna, and primary melanomas. These correlations were not more present in melanoma metastases. To summarize, earlier phases of melanoma progression seem to be connected with the loss of expression of Ku proteins. Metastatic spread is related to dysregulation of the Ku70 and Ku80 axis.

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Cutaneous melanoma in relation to intermittent and constant sun exposure—the western canada melanoma study

Cited by 277 publications

References 16 publications

Comportamento relativo à exposição e proteção solar na população de 15 anos ou mais de 15 capitais brasileiras e Distrito Federal, 2002-2003

Comportamento relativo à exposição e proteção solar na população de 15 anos ou mais de 15 capitais brasileiras e Distrito Federal, 2002-2003

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

Differential Expression of DNA Nonhomologous End-Joining Proteins Ku70 and Ku80 in Melanoma Progression

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