Opinion statementAs international travel has increased over the years, it is important for the clinician to be aware of communicable diseases in other countries. Infections can be characterized by endemic region, season of travel, method of transmission, and specific disease-defining lesions, which aid the clinician in developing a diagnosis and promptly initiating treatment. We describe common travel-acquired diseases by geographic location, key skin symptoms, and manifestations for early and proper diagnosis, as well as their standard treatment regimen.