Cutaneous meningiomas and an ovarian fibroma in a three‐year‐old girl

Junaid, T.A.; Nkposong, E.O.; Kolawole, T. M.

doi:10.1002/path.1711080211

Cited by 23 publications

(7 citation statements)

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“…The fiterature concerning cutaneous involvement by meningioma consists of one series, that of Lopez et al (15), and isolated case reports (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Sixteen of the 25 lesions described by Lopez et al were deemed to be primary cutaneous meningioma (PGM).…”

Section: Discussionmentioning

confidence: 99%

“…Other primary ectopic menitigiomas, of less certain origin, develop in the soft tissues of the head and rarely at sites more remote from the GNS, Each of the 3 categories of ectopic meningioma can involve the skin (1,(12)(13)(14)(15)(16), Such cutaneous involvement is invariably acquired and has the microscopic appearances of conventional meningioma. There is an additional group of meningeal lesions, often congenital, that arise entirely within the skin (15,(17)(18)(19)(20)(21)(22)(23)(24)(25). These have been termed primary cutaneous meningioma (PGM) (15).…”

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confidence: 99%

“…These have been termed primary cutaneous meningioma (PGM) (15). Whereas some have the pathologic appearances of conventional GNS meningioma (15,(17)(18)(19)(20)(21)23), others differ in important microscopic respects (15,22,24,25). Lopez et al (15), in their study of cutaneous meningiomas, suggested the terms "acoelic meningeal hamartoma" and "rudimentary meningocele" for this latter variant of PGM, The lesions were not illustrated in detail, however, and their microscopic distinction from the other forms of cutaneous involvement by meningioma was not emphasized.…”

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confidence: 99%

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Rudimentary meningocele: a variant of “primary cutaneous meningioma”

Sibley

Cooper

1989

J Cutan Pathol

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We studied 5 primary cutaneous meningiomas. All were congenital. Four were nodules or plaques on the scalp, and one was a lumbar polyp. Two were alopecic. A skull defect was present deep to one lesion, and the lumbar polyp was attached to dura. The tumors were concentrated in the subcutis, where strands of meningocytes were embedded in dense collageous tissue. Meningocytes wrapped around collagenous fibers, producing "collagen bodies". These formed the nidus for calcification that included psammoma bodies. Meningocytes also dissected between collagenous fibers, creating anastomosing spaces that mimicked a vascular tumor. Meningothelial-lined clefts, several milimeters in length, were present in 4 cases. Two lesions extended through dermal defects into the superficial dermis, where adnexa were reduced or absent. The meningocytes contained vimentin and epithelial membrane antigen. They lacked cytokeratin, S100 protein, and endothelial markers. The meningothelial lesions described herein lack the nodular and sheet-like growth patterns that typify meningiomas of the central nervous system and most primary ectopic meningiomas, including some that develop within the skin. They appear closely related to meningoceles and should be viewed as developmental abnormalities rather than neoplasms. The term "rudimentary meningocele" seems appropriate for these lesions.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Rudimentary meningocele: a variant of “primary cutaneous meningioma”

Sibley

Cooper

1989

J Cutan Pathol

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“…Unusual presentations of cutaneous meningioma have been reported for a set of siblings with occipital tumors in nearly identical locations, 11 for a case associated with sinus pericranii (a congenital vascular anomaly), 29 and for a case involving a 3-year-old girl with an ovarian fibroma. 30 In another case, a fetus demonstrated rapid third-trimester growth, and the authors 16 concluded that this was most likely due to the influence on the tumor by endogenous steroid hormones, similar to other meningiomas. However, these authors did not test for the presence of receptors on the described lesion.…”

Section: Associations and Geneticsmentioning

confidence: 95%

Cutaneous Meningioma

Miedema¹,

Zedek²

2012

Archives of Pathology &Amp; Laboratory Medicine

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Cutaneous meningioma is a rare tumor that most commonly occurs on the scalp and occurs in both congenital and acquired forms. It invokes a wide clinical differential diagnosis, but diagnosis is based on characteristic histologic and cytologic findings. Congenital lesions can often present years after birth and even in adult patients. Acquired lesions occur in adulthood. We review histologic, cytologic, and electron microscopic findings and explore how these are used to separate this entity from other entities in the differential diagnosis. While ultrastructural and cytologic findings are similar to those of more common intracranial meningiomas, these tumors exhibit a range of histologic differences. A lack of awareness of this entity precludes correct diagnosis.

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“…Primary extradural meningiomas have been reported to occur in the calvaria, 7 scalp, 8 nasopharynx, 9 orbit, 10 paranasal sinuses, 11 neck, 12 and skin. 13 Rare meningiomas occurring in the lung, 14 mediastinum, 15 phalanges, 16 and paraspinal region 17 have also been reported.…”

Section: 2mentioning

confidence: 99%

Meningioma of the Mandible: Imaging with CT

Mussak

Holodny²,

Karimi³

2007

American Journal of Neuroradiology

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SUMMARY:We present the first description of CT of a meningioma of the mandible in the literature. Extracranial meningiomas are exceedingly rare. There have been 3 cases of meningioma of the mandible described in the literature, but none characterized with cross-sectional imaging. We describe the clinical and CT features used to establish the diagnosis as well as how to differentiate this lesion from other pathology of the mandible. Only 3 cases of a meningioma of the mandible have been described in the literature.1,2 The mandibular meningiomas are classified as primary extracranial meningiomas. Extracranial meningiomas are usually an extension of an intracranial tumor but can arise independently, such as meningioma of the mandible. The independent formation of these tumors is believed to involve meningocytes along the sheaths of cranial nerves as they exit the skull foramina, fibroblastic mesenchymal cell transformation, or displaced arachnoid cap cells. Metastasis from a central nervous system (CNS) meningioma can naturally give rise to an "ectopic" meningioma as well. Extracranial meningiomas are exceptionally rare. To our knowledge, we report the first CT findings of a mandibular meningioma. Case ReportA 62-year-old man presented with fullness on the left mid-body of the mandible. The patient's history dated to 2 years earlier when he sought consultation from his dentist. A swelling was noted on his left lower gum with mild pain, which was clinically thought to represent an abscess. Plain films revealed a large well-delineated radiolucent lesion involving the mandibular body. He was treated with 4 different antibiotic regimens during the following year with no regression of the mass. The patient denied any bleeding from the oral cavity or any problems with speech or mastication. At that point, his primary care physician referred him to an otolaryngologist for further management and work-up of the mass.The work-up included a CT of the mandible without contrast, which showed a well-circumscribed lytic expansile mass involving the mandibular body on the left side, which broke through the cortex at several different sites. The mass measured approximately 7 ϫ 3 cm (anteroposterior ϫ transverse) and spanned from the alveolar ridge to the inferior cortex. Posteriorly, the lesion extended 1 cm from the angle of the mandible and anteriorly 1.8 cm from the mentum (Fig 1). There was no evidence of gross tumor extending into the infratemporal fossa along the course of V3, and the foramen ovale was normal on the CT scan.A fine-needle aspiration of the mass was performed. Cytologic analysis revealed neoplastic spindle cells present with minimal nuclear and cytologic atypia. The sample was reviewed at an intradepartmental pathology conference and was determined to represent an extracranial meningioma. The patient was then recommended for segmental mandibulectomy and mandibular reconstruction with a fibula free flap.Postoperatively, the left submandibular gland and left mandible were submitted to surgical pathology for analy...

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Cutaneous meningiomas and an ovarian fibroma in a three‐year‐old girl

Cited by 23 publications

References 11 publications

Rudimentary meningocele: a variant of “primary cutaneous meningioma”

Rudimentary meningocele: a variant of “primary cutaneous meningioma”

Cutaneous Meningioma

Meningioma of the Mandible: Imaging with CT

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