Thyroid carcinoma represents 1% to 1.5% of all cancer cases reported annualy and accounts for 57% of all deaths caused by endocrine malignancies. [1] Well-differentiated thyroid carcinomas including papillary and follicular carcinoma are the most common thyroid malignancies comprising approximately 70% and 10% respectively, of all cases. Scalp as a distinct cutaneous area has a rich dermal vasculature and is a site of various primary and metastatic neoplasms. Different visceral malignancies such as cancers of lung, breast, thyroid, colon, kidney, adrenal glands and larynx can metastasize to scalp. Metastases to scalp from thyroid carcinomas are extremely rare and demonstrate advanced disease and poor prognosis. Such lesions may indicate treatment failure or alternatively they may be the
ÖzetBu derlemede literatürde skalp metastaz› yapt›¤› bildirilen tiroid karsinom vakalar› taranarak tan›sal, histopatolojik ve prognostik özellik-leri ile tart›fl›ld›. PubMed ve MedLine servislerinde yay›nlanan tüm tiroid karsinomlar›na ba¤l› skalp metastaz› vakalar› araflt›r›ld› ve hastalar›n yafl ve cinsiyetine, tiroid karsinomunun histolojik tipine, skalp d›fl›nda cilt alanlar›na metastazlar›na ve primer tümörün teflhisiyle metastaz teflhisi aras›ndaki süreye iliflkin verilere ulaflmak için hasta bilgileri incelendi. Literatürde günümüze kadar bildirilen 38 vaka bulundu. Bildirilen vakalarda en s›k görülen histolojik tip foliküler karsinom (%46) idi. Papiller karsinom, medüller karsinom ve anaplastik karsinom vakalar›n›n oranlar› ise s›ras›yla %35, %16 ve %3 olarak bulundu. Özel bir cilt alan› olan skalp zengin bir damar a¤›na ve kanlanmaya sahip olup çeflitli primer veya metastatik tümörlerin oda¤› olabilir. Tiroid karsinomlar›na ba¤l› skalp metastazlar› oldukça nadir olup ilerlemifl hastal›¤a ve kötü prognoza iflaret eder. Düflük metastatik potansiyele sahip gizli bir neoplazm›n ilk belirtisi olarak ç›kabilen bir skalp nodülünün teflhisi oldukça güç olabilir. Tiroid karsinomlar›-n›n histopatolojik özelliklerinin ve cilt metastaz› kal›plar›n›n bilinmesiyle bu gibi lezyonlar›n tan›s›na daha kolay ulafl›labilir.Anahtar sözcükler: Metastaz, skalp, tiroid karsinomu.
AbstractThyroid carcinomas reported to metastasize to scalp were reviewed and discussed with histopathological, prognostic and diagnostic aspects. All cases of scalp metastasis from thyroid carcinomas published in PubMed and MedLine were reviewed and the data of all patients were analyzed to obtain information about the patient demographics, histologic type of thyroid carcinoma, additional cutaneous sites, time interval between the diagnosis of the primary tumor and the diagnosis of scalp metastasis. The literature review revealed 38 cases of scalp metastasis from thyroid carcinoma. The most common histologic type was follicular carcinoma (46%), followed by papillary (35%), medullary (16%) and anaplastic carcinomas (3%). Scalp as a distinct cutaneous area has a rich dermal vasculature and is a site of various primary and metastatic neoplasms. Metastases to scalp from ...