Cutaneous metastases from neuroendocrine carcinoma of the cervix—An unusual metastatic lesion from an uncommon malignancy

Devnani, Bharti; Kumar, Ritesh; Pathy, Sushmita; Phulware, Ravi Hari; Mathur, Sandeep; Kumar, Lalit

doi:10.1016/j.currproblcancer.2018.04.004

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Subcutaneous and intramuscular metastasis of NECC is seldom seen as well. There have been only four reported cases of cutaneous metastasis of NECC, in which the metastatic lesions were described as multiple, firm and nonulcerated nodules measuring from 2 to 20 mm, generally in consistency with the presentation of this case.…”

Section: Discussionsupporting

confidence: 69%

Rare case of tonsillar and subcutaneous metastasis from neuroendocrine cervical cancer

Zeng

Tuo

Liu

et al. 2020

J of Obstet and Gynaecol

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Section: Discussionsupporting

confidence: 69%

Rare case of tonsillar and subcutaneous metastasis from neuroendocrine cervical cancer

Zeng

Tuo

Liu

et al. 2020

J of Obstet and Gynaecol

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“…22 The extirpation of skin lesions followed by radiotherapy is the primary treatment for these patients. 23,24 In most cases, 19,25 surgical resection and/or radiotherapy were used for limited lesions, and palliative chemotherapy was used for extensive lesions.…”

Section: Discussionmentioning

confidence: 99%

Skin metastasis in squamous cell cancer of cervix: A case report

Zhao

Chen

Zhou

2023

Precision Radiation Oncology

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Cervical cancer, the fourth most common cancer among females in the world, ranks the second in China. In advanced disease, metastases may be commonly present in the lungs, bones, liver and lymph nodes or elsewhere, but uncommon to the skin. In this report, a 63‐year‐old woman was diagnosed as stage IVB cervical squamous cell cancer in January 2021. The patient was scheduled for concurrent chemoradiotherapy; however, a metastatic lesion of skin was proved by biopsy during the process of treatment. She died 1 month after confirmed skin metastases. Cutaneous metastasis of cervical cancer may predict the mix of lymphatic and hematogenous metastasis and the rapid fatal termination.

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“…Cases of skin (cutaneous/subcutaneous) metastases derived from neuroendocrine tumors of the lung [3][4][5][6][7][8], gastrointestinal [2,[9][10][11] and genitourinary tract [12][13][14][15] as well as of other origins or with unknown primary tumor site [16][17][18] have been exceptionally reported. In line with observations and revisions by Amorim et Al.…”

Section: Discussionmentioning

confidence: 99%

Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

Ciliberti¹,

Carbonara

Grillo³

et al. 2020

BMC Cancer

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Background: Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of metastatic PNEC with multiple visceral and subcutaneous secondary lesions, focusing on the effectiveness of palliative radiotherapy for skin metastases. Case presentation: A 61-years old woman affected by a metastatic PNECwith subcutaneous growing and bleeding secondary lesions (at the scalp, right scapular region and at the back of the left thoracic wall, respectively) obtained a successful control of visceral metastases with the use of chemotherapy and an unexpected local response of her skin metastases with palliative radiotherapy. In particular, two subsequent radiation treatments were performed using different fractionation schedules (30 Gy in 10 fractions and 20 Gy in 5 fractions, respectively). Both radiation treatments were well-tolerated and patient's quality of life was improved. Local response was maintained until patient's deaththat occurred due to cachexia. Conclusions: The presented case highlights the effectiveness and the good tolerance of radiotherapy in the treatment of subcutaneous metastases; nevertheless, further knowledge of the optimal local palliative approach for PNEC metastatic sites is necessary. The experience gained in this work is the occasion to encourage a routine integrated multidisciplinary team management of metastatic PNECs because of their clinical complexity. The aim is to guarantee the optimization of the care with personalized and more effective systemic and local treatmentsalso including supportive cares and treatment-related side effects management.

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Cutaneous metastases from neuroendocrine carcinoma of the cervix—An unusual metastatic lesion from an uncommon malignancy

Cited by 6 publications

References 8 publications

Rare case of tonsillar and subcutaneous metastasis from neuroendocrine cervical cancer

Rare case of tonsillar and subcutaneous metastasis from neuroendocrine cervical cancer

Skin metastasis in squamous cell cancer of cervix: A case report

Unexpected response to palliative radiotherapy for subcutaneous metastases of an advanced small cell pancreatic neuroendocrine carcinoma: a case report of two different radiation schedules

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