Cutaneous Metastasis Revealing a Widely Disseminated Follicular Thyroid Carcinoma

Boughattas, Sami; Hassine, Habib; Chatti, K.; Jomaa, R.; Essabbah, H.

doi:10.1097/00003072-200205000-00021

Cited by 6 publications

(3 citation statements)

References 5 publications

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“…Cutaneous metastases from well‐differentiated thyroid carcinoma are rare, but there are a number of case reports and small series in the literature 3–17. In a study of 91 patients with PTC with distant metastases, only 6 had cutaneous metastases 18.…”

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Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Erickson

Jin

Nakamura

et al. 2007

Cancer

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BACKGROUNDCutaneous metastases from well‐differentiated thyroid carcinomas are rare and are usually identified in patients with widely disseminated disease. Occasionally, thyroid carcinomas can present as cutaneous metastases for which the primary site needs to be determined. Papillary thyroid carcinomas (PTCs) commonly have BRAFV600E mutation. A series of 16 cutaneous metastases were analyzed from well‐differentiated thyroid carcinomas to learn more about the clinicopathologic features and BRAFV600E mutation status.METHODSEleven cases of PTC and 5 of follicular thyroid carcinoma (FTC) metastatic to the skin were evaluated. All cutaneous metastases were studied histologically and with thyroglobulin and thyroid transcription factor immunostains. All tumor samples were analyzed for mutations at nucleotide 1799 in exon 15 of the BRAF gene.RESULTSTwo patients with FTC presented with cutaneous metastases. Fourteen of 16 patients died of disease and 2 were alive with disease at follow‐up. The histologic features of the cutaneous metastases were generally characteristic of the primary tumor; however, 2 of the 11 PTC metastases demonstrated cytoplasmic clearing not typical of classic PTC. BRAFV600E mutation (T1799A) was detected in 5 of 11 cases of PTC and in none of the 5 FTCs.CONCLUSIONSCutaneous metastases from PTC may show prominent clear cell change requiring differentiation from clear cell hidradenoma, clear cell dermatofibroma, malignant melanoma with prominent clear cell change, and cutaneous metastasis from renal cell carcinoma. BRAFV600E mutation is identified in a subset of cutaneous metastases from PTC. Cutaneous metastases from PTC and FTC are associated with a very poor prognosis. Cancer 2007. © 2007 American Cancer Society.

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confidence: 99%

Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Erickson

Jin

Nakamura

et al. 2007

Cancer

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“…7,37 Data are sometimes lacking on the outcomes for these patients however death was reported in just 3 (25%) cases (mean 4.5 years from SM), however one case developed wide dissemination of disease without observed death. 38 Anaplastic and poorly differentiated carcinoma of the thyroid caused death and/or dissemination of disease in all patients where reported (five/six cases). The average time to death was only 3 months following appearance of SM, which manifest at varying times (1 week to 6 months) after cancer diagnosis.…”

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confidence: 90%

Cutaneous Metastasis of Head and Neck Malignancy

Emanuel¹,

Emanuel²

2015

International Journal of Head and Neck Surgery

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Background Noncutaneous cancers of the head and neck occasionally metastasize to skin. We present a case series of patients with skin metastases from non-cutaneous malignancies of the head and neck. A literature review is presented to assess the morphology, pattern of distribution, and morbidity of skin metastases. Methods Relevant cases were identified by a dermatopathologist and cases were reviewed. A literature search yielded 94 cases which were also included. Results The most common primary site, histology, and location of spread was the thyroid gland (42%), squamous cell carcinoma (42%), and scalp (25%) respectively. Skin metastases typically present as a discrete nodules, but the distribution varies. Metastases to skin can occasionally be a patients presenting complaint, but irrespective of timing of presentation portend a poor prognosis. Conclusion Skin metastases are clinically rare, and when present typically herald a poor overall prognosis. Information regarding their distribution and clinical presentation is of importance to the surgeon and oncologist. How to cite this article Emanuel H, Emanuel P. Cutaneous Metastasis of Head and Neck Malignancy. Int J Head Neck Surg 2015;6(2):57-63.

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“…The patient had a markedly elevated serum thyroglobulin level but her cancer was not avid in trapping radioiodine, and thus a PET/CT scan was performed. 1,[3][4][5][6][7] There is no clear explanation for this, although the lymphatic communication from the thyroid to the nodes posterior to the orbit that were identified by Kriss might be a factor. 1 Although differentiated carcinomas are the most common thyroid cancers causing skin metastases, dermatologic involvement has also been reported in anaplastic thyroid carcinoma.…”

Section: Figurementioning

confidence: 99%

F-18 FDG PET/CT Imaging of a Subcutaneous Scalp Metastasis From Primary Carcinoma of the Thyroid

Niederkohr¹,

Dadras²,

Leavitt³

et al. 2007

Clinical Nuclear Medicine

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Differentiated thyroid cancer frequently metastasizes but typically spreads to regional cervical lymph nodes and, in advanced cases, to the lungs and/or skeleton. Metastases to the skin/subcutaneous tissue are rare. We report a case of abnormal FDG uptake within a scalp metastasis on PET/CT in a patient with metastatic papillary thyroid carcinoma. Because thyroid cancer can rarely metastasize to the skin and particularly the scalp, attention should be given to that region during interpretation of the images.

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Cutaneous Metastasis Revealing a Widely Disseminated Follicular Thyroid Carcinoma

Cited by 6 publications

References 5 publications

Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Cutaneous Metastasis of Head and Neck Malignancy

F-18 FDG PET/CT Imaging of a Subcutaneous Scalp Metastasis From Primary Carcinoma of the Thyroid

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Cutaneous Metastasis Revealing a Widely Disseminated Follicular Thyroid Carcinoma

Cited by 6 publications

References 5 publications

Clinicopathologic features and BRAFV600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Clinicopathologic features and BRAFV600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Cutaneous Metastasis of Head and Neck Malignancy

F-18 FDG PET/CT Imaging of a Subcutaneous Scalp Metastasis From Primary Carcinoma of the Thyroid

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Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas

Clinicopathologic features and BRAF^V600E mutation analysis in cutaneous metastases from well‐differentiated thyroid carcinomas