2017
DOI: 10.1113/ep086239
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Cutaneous microvascular perfusion responses to insulin iontophoresis are differentially affected by insulin resistance after spinal cord injury

Abstract: What is the central question of this study? What impact does insulin resistance have on cutaneous perfusion responses to insulin iontophoresis in vascular beds with markedly reduced or functionally ablated sympathetic nervous system vasomotor function resulting from spinal cord injury? What is the main finding and its importance? Persons with spinal cord injury have sublesional microvascular endothelial dysfunction, as indicated by a blunted cutaneous perfusion response to acetylcholine iontophoresis, and the … Show more

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Cited by 4 publications
(1 citation statement)
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“…One recent study (2) has implicated autonomic dysregulation in SCI patients as a primary mechanism of subcutaneous malabsorption using insulin and acetylcholine iontophoresis. Decreased sympathetic innervation to the endothelial vascular bed results in downregulation of α and β adrenergic receptors and endothelial dysfunction (2). Without sympathetic outflow, it is possible that nitric oxide (NO) levels remain unopposed, leading to desensitization of guanylyl cyclase, the NO receptor.…”
Section: Discussionmentioning
confidence: 99%
“…One recent study (2) has implicated autonomic dysregulation in SCI patients as a primary mechanism of subcutaneous malabsorption using insulin and acetylcholine iontophoresis. Decreased sympathetic innervation to the endothelial vascular bed results in downregulation of α and β adrenergic receptors and endothelial dysfunction (2). Without sympathetic outflow, it is possible that nitric oxide (NO) levels remain unopposed, leading to desensitization of guanylyl cyclase, the NO receptor.…”
Section: Discussionmentioning
confidence: 99%