Cutaneous Myoepithelioma: An Unusual Tumor in the Hand

Montalvo, Nelson; Redrobán, Ligia; Galarza, David; Ramírez, Iván Hernández

doi:10.1155/2020/3747013

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…Tumors with similar morphologic appearances have been documented to affect acral sites previously in individual case reports or as a part of larger series, but their predilection for acral skin has not been emphasized yet 11,21–26. In addition, Antonescu and colleagues reported similar tumors as “skin and soft tissue myoepitheliomas with ductal differentiation.” They reported a marked predilection for acral skin with 8 of 13 tumors involving the hands or feet with frequent PLAG1 rearrangement, analogous to salivary gland pleomorphic adenomas 7.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Mehta¹,

Davey

Gharpuray-Pandit

et al. 2022

American Journal of Surgical Pathology

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Cutaneous myoepithelial neoplasms are a heterogenous group of neoplasms with mixed tumors typically affecting the head and myoepitheliomas showing a predilection for the extremities. Their malignant counterparts, myoepithelial carcinoma, and malignant mixed tumor are exceptionally rare in the skin, and the morphologic criteria for malignancy are only poorly defined. The aim of the present study was to characterize the clinicopathologic features of myoepithelial neoplasms presenting on acral skin. The clinical and histopathologic features of 11 tumors were recorded, and follow-up was obtained. Immunohistochemistry was performed for S100, SOX10, glial fibrillary acidic protein, keratins, epithelial membrane antigen, p63, p40, smooth muscle actin, desmin, and PLAG1. The tumors mainly affected the feet of adults (range: 26 to 78 y; median: 47 y) with a predilection for the great toe and a male predominance of 1.8:1. Most tumors (91%) displayed a lobular architecture composed of solid and nested growth of epithelioid cells with plasmacytoid features in a myxoid or angiomatous stroma. Scattered cytologic atypia and rare duct differentiation were frequently noted. Three tumors with confluent cytologic atypia, infiltrative growth, and lymphovascular invasion were classified as malignant. By immunohistochemistry, the tumors were positive for S100, SOX10, keratins AE1/AE3, CK5/6 and CK7, and PLAG1. Local recurrence and bilateral pulmonary metastasis were observed in a patient presenting with a histopathologically benign-appearing tumor. Two patients with malignant tumors experienced local recurrences, and 1 developed metastasis to soft tissue, lung, and mediastinal lymph nodes. All patients are currently alive, all but 1 with no evidence of disease after a median follow-up interval of 96 months (range: 2 to 360 mo). In conclusion, acral myoepithelial neoplasms show distinctive and reproducible histopathologic and immunohistochemical features. They are best regarded as a distinctive subset of mixed tumors with features reminiscent of their salivary gland counterparts. While most tumors pursue a benign disease course, histopathologic features appear to be a poor indicator of prognosis.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Mehta¹,

Davey

Gharpuray-Pandit

et al. 2022

American Journal of Surgical Pathology

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“…2,5 Differential diagnoses of myoepithelial neoplasms include epithelioid fibrous histiocytoma, early juvenile xanthogranuloma, Spitz naevus, ossifying fibromyxoid tumour and epithelioid sarcoma. 6 In particular, from a dermoscopic point of view, a highly vascularises papular lesion with no pigment network in a child should raise suspicion for a spitzoid neoplasm. 7 To the best of our knowledge, dermoscopic features of cutaneous myoepithelioma have not been described.…”

Section: Discussionmentioning

confidence: 99%

A slowly growing, highly vascularized papule in a 4‐year‐old girl

Tartaglia

Ciolfi

Caroppo

et al. 2023

JEADV Clinical Practice

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“…1 , 2 , 6 They usually present as variably sized painless nodules in the limbs or limb girdles, and rarely in the trunk, head and neck, bone, viscera or skin. 7–10…”

Section: Discussionmentioning

confidence: 99%

EWSR1-ATF1 Fusion in a Myoepithelial Carcinoma of Soft Tissue With Small Round Cell Morphology: A Potential Diagnostic Pitfall

2021

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Myoepithelial tumors of soft tissue are rare mesenchymal neoplasms that overlap with their salivary gland and skin counterparts at both the histopathologic and molecular levels. EWSR1 gene rearrangements with various fusion partners represent a common genetic event in myoepithelial tumors of soft tissue, whether benign or malignant, and may prove useful as a diagnostic tool in difficult cases. However, the number of diagnostic entities with EWSR1 gene rearrangements has grown considerably in recent years, and there is significant morphologic and immunophenotypic overlap amongst this group, underscoring the importance of fusion testing to detect fusion partners that are characteristic of discrete diagnostic entities. Herein, we report a malignant myoepithelial tumor of soft tissue/myoepithelial carcinoma with an undifferentiated round cell morphology arising in a pediatric patient with a EWSR1-ATF1 gene fusion.

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Cutaneous Myoepithelioma: An Unusual Tumor in the Hand

Cited by 8 publications

References 24 publications

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

Cutaneous Myoepithelial Neoplasms on Acral Sites Show Distinctive and Reproducible Histopathologic and Immunohistochemical Features

A slowly growing, highly vascularized papule in a 4‐year‐old girl

EWSR1-ATF1 Fusion in a Myoepithelial Carcinoma of Soft Tissue With Small Round Cell Morphology: A Potential Diagnostic Pitfall

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