Cutaneous Pharmacokinetics: 10 Steps to Percutaneous Absorption

Wester, Ronald C.; Maibach, Howard I.

doi:10.3109/03602538308991388

Cited by 220 publications

(71 citation statements)

References 51 publications

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“…There is also evidence that lipophilic substances can pass from the nasal cavity directly into cerebrospinal fluid (Sakane et al 1991). Percutaneous absorption of small molecules into circulation is well established (Wester & Maibach 1983) and is affected by several Figure 3 Mean (GS.E.M.) radioactivity in the uterus, ovaries, muscle, olfactory bulbs (OB), mesencephalon and diencephalon (MCCDC), and cerebral cortex of inseminated females intranasally administered 10 ml ethanol (control), 10 mCi tritium-labelled oestradiol ( 3 H-E 2 ), 10 mCi tritium-labelled testosterone ( 3 H-T), or 10 mCi tritium-labelled progesterone ( factors including molecular mass, solubility and polarity (Schaefer et al 1982).…”

Section: Discussionmentioning

confidence: 99%

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

Guzzo¹,

Jheon²,

Imtiaz³

et al. 2012

Reproduction

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Male mice actively direct their urine at nearby females, and this urine reliably contains unconjugated oestradiol (E 2 ) and other steroids. Giving inseminated females minute doses of exogenous E 2 , either systemically or intranasally, can cause failure of blastocyst implantation. Giving juvenile females minute doses of exogenous E 2 promotes measures of reproductive maturity such as uterine mass. Here we show that tritium-labelled E 2 ( 3 H-E 2 ) can be traced from injection into novel male mice to tissues of cohabiting inseminated and juvenile females. We show the presence of 3 H-E 2 in male excretions, transmission to the circulation of females and arrival in the female reproductive tract. In males, 3 H-E 2 given systemically was readily found in reproductive tissues and was especially abundant in bladder urine. In females, 3 H-E 2 was found to enter the system via both nasal and percutaneous routes, and was measurable in the uterus and other tissues. As supraoptimal E 2 levels can both interfere with blastocyst implantation in inseminated females and promote uterine growth in juvenile females, we suggest that absorption of male-excreted E 2 can account for major aspects of the Bruce and Vandenbergh effects.

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Section: Discussionmentioning

confidence: 99%

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

Guzzo¹,

Jheon²,

Imtiaz³

et al. 2012

Reproduction

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show abstract

“…Scrota1 skin is 42 times more permeable than forearm skin (24). Experimental damage to human skin (stripping with tape until it glistens) and occlusion and hydration of skin may increase penetration by 20-fold.…”

mentioning

confidence: 99%

Respiratory symptoms, spirometry and chronic occupational paraquat exposure

Castro-Gutiérrez¹,

McConnell²,

Andersson³

et al. 1997

Scand J Work Environ Health

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“…The TINA test (Tierexperimenteller Nachweistest) (Ziegler & Suss 1985) is developed from the method described by Polak et al (1968). The procedure is time consuming, sensitive and combines intradermal and topical administration of the test substance, and the use of Freund's complete adjuvant.…”

Section: Methods Using Both Application Routesmentioning

confidence: 99%

“…The time-course relationship will of course vary from allergen to allergen depending upon a number of factors e.g. vehicle release, absorption kinetics, cellular distribution, substantivity, volatility, wash-and-rub resistance, and binding (Wester & Maibach 1983).…”

Section: Mode and Route Of Exposurementioning

confidence: 99%

Testing for Contact Allergy in Experimental Animals

Andersen

1987

Pharmacology & Toxicology

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Cutaneous Pharmacokinetics: 10 Steps to Percutaneous Absorption

Cited by 220 publications

References 51 publications

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

Oestradiol transmission from males to females in the context of the Bruce and Vandenbergh effects in mice (Mus musculus)

Respiratory symptoms, spirometry and chronic occupational paraquat exposure

Testing for Contact Allergy in Experimental Animals

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