Respiratory symptoms, spirometry and chronic occupational paraquat exposure

Castro-Gutiérrez, Néstor; McConnell, Rob; Andersson, Kjell; Pacheco-Antón, Feliciano; Hogstedt, Christer

doi:10.5271/sjweh.264

Cited by 46 publications

(34 citation statements)

References 40 publications

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“…In the case of occupational exposure to paraquat, there was a dose-response relationship with the risk of chronic cough or dyspnoea, breathlessness and wheezing [32,37]. Among pesticide applicators, several studies showed impairments in respiratory function, especially with paraquat (reduction associated with the number of years of application) [48] and organophosphate, carbamate, neonicotinoid insecticides and bipyridylium herbicides, sometimes with a dose-effect relationship [46].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, assessment of exposure is also generally based on self-reports. However, some studies [37,38,44,46,47,58] assessed cumulative lifetime exposure to pesticides, while others asked about specific pesticides used [32,37,64,65] or specific crops [34,56], allowing a more precise definition of exposure. Finally, even for asthma, it is difficult to establish a causal relationship with exposure to pesticides.…”

Section: Discussionmentioning

confidence: 99%

“…nonsprayer plantation workers. They suffered more frequently from severe dyspnoea (least exposed: OR 2.8; most exposed: OR 4.6) and episodic breathlessness and wheezing (most heavily exposed: OR 2.9) [32].…”

Section: Studies On Agricultural Workersmentioning

confidence: 99%

“…Working in the agricultural sector was assumed to be equivalent to being exposed to pesticides. However, although only a few studies assessed lifelong pesticide use and calculated cumulative exposure indexes, they all found a dose-effect relationship [32,37,46,48]. Table 2 presents a summary of the longitudinal studies on respiratory health and occupational pesticide exposure.…”

Section: Studies On Agricultural Workersmentioning

confidence: 99%

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Occupational exposure to pesticides and respiratory health

et al. 2015

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This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.Among the 15 cross-sectional studies focusing on respiratory symptoms and agricultural pesticide exposure, 12 found significant associations with chronic cough, wheeze, dyspnoea, breathlessness or chest tightness. All four studies on asthma found a relationship with occupational exposure, as did all three studies on chronic bronchitis. The four studies that performed spirometry reported impaired respiratory function linked to pesticide exposure, suggestive of either obstructive or restrictive syndrome according to the chemical class of pesticide.12 papers reported results from cohort studies. Three out of nine found a significant relationship with increased risk of wheeze, five out of nine with asthma and three out of three with chronic bronchitis. In workers employed in pesticide production, elevated risks of chronic obstructive pulmonary disease (two studies out of three) and impaired respiratory function suggestive of an obstructive syndrome (two studies out of two) were reported.In conclusion, this article suggests that occupational exposure to pesticides is associated with an increased risk of respiratory symptoms, asthma and chronic bronchitis, but the causal relationship is still under debate. @ERSpublications A review of occupational (agricultural and industry) exposure to pesticides and associated respiratory health effects http:///ow.ly/M09Gc

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Studies On Agricultural Workersmentioning

confidence: 99%

Section: Studies On Agricultural Workersmentioning

confidence: 99%

See 2 more Smart Citations

Occupational exposure to pesticides and respiratory health

et al. 2015

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“…However, the occupational hazards presented by chronic paraquat exposure are less well characterized, and epidemiologic studies have not shown consistent pulmonary changes among paraquat handlers (16)(17)(18)(19)(20). Castro-Gutierrez and colleagues (19) found that exposure to paraquat, as estimated by skin rash symptoms, was related to selfreported respiratory symptoms (chronic bronchitis and episodic dyspnea with wheezing) but they did not observe an association of paraquat exposure with pulmonary function changes measured by spirometry. A study of 85 Sri Lankan paraquat applicators found no difference in respiratory symptoms, spirometry, or diffusion capacity compared with control subjects comprised of factory workers and general workers (18).…”

mentioning

confidence: 99%