Cutaneous T-Cell/Histiocyte-Rich B-Cell Lymphoma: A Case Report and Review of the Literature

Abstract

Background: T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) primarily presenting on the skin is an extremely rare entity with only sporadic cases reported in the literature. Methods: We here report an extraordinary case of primary cutaneous THRLBCL with self-healing and 24 months of follow-up. Results: The lesion was a dermohypodermal/subcutaneous circumscribed ulcerated nodosity. Histological examination with immunohistochemical, molecular analysis and comparative genomic hybridization were performed. A complete staging was negative for secondary involvement. Conclusion: Our case is remarkable because it is the second well-documented primary cutaneous THRLBCL in which we observed a complete self-regression of skin lesions without recurrences or dissemination of the disease. According to the literature, we highlight that the tumoral microenvironment, in our case, could play a relevant role in stopping lymphoma growth. Furthermore, this case supports the observation that THRLBCL primarily presenting on the skin shows an overall good prognosis.

Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature

“…T/HRBCL is a nodal disease, but extralnodal sites, such as spleen, liver and bone marrow can be involved[10-12,20,21]. In recent reports, primary cutaneous[22], thyroid[23], thymus[24], and gastrointestinal presentations[25,26] of T/HRBCL were also described. To date, pancreatic involvement of T/HRBCL has not been reported.…”

Histopathological and cytological spectrum of lymphadenopathy: a window to preliminary diagnosis

“…Classical Hodgkin lymphoma can also resemble T-cell / histiocyte-rich large B-cell lymphoma or peripheral Tcell lymphoma [35]. For these reasons, fine needle aspiration cytology (FNAC) is considered less accurate for the diagnosis of Hodgkin lymphoma than it is for non-Hodgkin lymphoma [36].…”

Extranodal T-cell/Histiocyte-rich Large B-cell Lymphoma Presenting Primarily on the Skin

“…In addition, Kodama et al reported previously that LBCL-o showed a better prognosis compared with other subtypes of LBCLs. THRLBCL is categorized as a variant of LBCL-o, and is known to have a relatively good prognosis (1,4). Cutaneous Hodgkin's lymphoma, which ir required for a diagnosis of THRLBL, was excluded based on a negative result for CD15 immunostaining.…”

“…T-cell/histiocyte-rich Large B-cell lymphoma (THRLB-CL) presenting primarily on the skin is an extremely rare entity (1). THRLBCL is considered a subtype of diffuse large B-cell lymphoma, and is characterized by a limited number of scattered, large, atypical B cells embedded in a background of abundant T cells and histiocytes (1). In general, THRLBCL mainly affects the lymph nodes and often presents as stage IV disease.…”