Pancreatic T/histiocyte-rich large B-cell lymphoma: A case report and review of literature

Abstract

Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma. The most common histological subtype of PPL is diffuse large B cell lymphoma (DLBCL). In rare cases, PPL can also present as follicular lymphoma, small lymphocytic lymphoma, and T cell lymphoma either of non-Hodgkin’s lymphoma or of Hodgkin’s lymphoma. T-cell/histiocyte-rich large B-cell lymphoma (T/HRBCL) is an uncommon morphologic variant of DLBCL with aggressive clinical course, it is predominantly a nodal disease, but extranodal sites such as bone marrow, liver, and spleen can be involved. Pancreatic involvement of T/HRBCL was not presented before. Herein, we report a 48-year-old male who was hospitalized with complaints of jaundice, dark brown urine, pale stools, and nausea. The radiological evaluation revealed a pancreatic head mass and, following operative biopsy, the tumor was diagnosed as T/HRBCL. The patient achieved remission after six cycles of CHOP chemotherapy. Therefore, T/HRBCL can be treated similarly to the stage-matched DLBCL and both of them get equivalent outcomes after chemotherapy.

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: Report of the First Case in the Mandible

“…In the present case, malignant B-cells were positive for CD20 and Bcl-2 and negative for CD30, and the reactive background infiltrate was positive for CD5, CD45RO and CD68. This corroborates the immunohistochemical findings reported in the literature for THRLBCL in other locations [8,[21][22][23][24][25][26][27]. The immunohistochemistry findings in the present case were fundamental to the direction of the final diagnosis of this rare variant of DLBCL localized in the jaw, owing to the similarity of the clinical and radiographic characteristics of this case with those of other typical cases of DLBCL described in the literature [13,16].…”

Obstructive Jaundice Secondary to Pancreatic Head Metastasis of Malignant Amelanotic Melanoma as the First Clinical Manifestation

“…Our case is the first one to describe biliary obstruction caused by malignant melanoma metastasis to the head of pancreas. Very few other secondary tumours to the head of pancreas, such as for example multiple myeloma or diffuse large B cell lymphoma causing obstructive jaundice, have previously been described (Zheng et al, 2017;Umemura et al, 2018). Cases of malignant melanoma metastasis to the ampulla of Vater causing jaundice are the most similar to our case.…”

Primary Pancreatic Lymphoma: An Uncommon Presentation in the Pancreatic Tail

“…CT- or EUS-guided fine needle aspiration (FNA) biopsy is the initial approach. If FNA is nondiagnostic, laparoscopy or laparotomy may be performed [12]. The histological subtype is a major prognostic factor in nodal and extra-nodal lymphomas.…”