Primary Pancreatic Lymphoma: An Uncommon Presentation in the Pancreatic Tail

Zafar, Yousaf; Kaur, Anahat; Banno, Fady; Shrestha, Anuj

doi:10.7759/cureus.5479

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…Primary pancreatic lymphoma (PPL) is often, therefore, only diagnosed postoperatively [1][2][3] and not commonly diagnosed in the tail of the pancreas. 4 It is important to differentiate PPL from pancreatic adenocarcinoma because the treatment and prognosis vary significantly between these two entities.…”

Section: Discussionmentioning

confidence: 99%

Differentiating Primary Pancreatic Lymphoma Versus Primary Splenic Lymphoma: A Case Report

Ries

Jacovides

Rashti

et al. 2021

Journal of Pancreatic Cancer

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Background: Both primary pancreatic lymphoma (PPL) and primary splenic lymphoma (PSL) represent rare entities. PPL typically arises in the head of the pancreas but may arise in other locations also. PSL usually presents with nonspecific symptoms, including left upper quadrant pain, weight loss, and fever. This report describes a patient with a large left upper quadrant mass, which initially was believed to be a primary pancreatic mass, but which on final pathology appeared to be consistent with a PSL. Presentation: The patient is a 64-year-old woman who initially presented with symptoms of left upper quadrant abdominal pain and distension; she subsequently was found to have an 18 cm heterogeneous mass arising from the pancreatic tail. She underwent a distal pancreatectomy with splenectomy. Final pathology confirmed a diffuse large B cell lymphoma arising from the splenic parenchyma. Conclusions: Both PPL and PSL are rare causes of left upper quadrant masses. In this case, we describe a large lymphoma that appeared to arise from the tail of the pancreas, but on final pathology was found to be splenic in origin. Differentiating these two clinical entities is important for prognostication and treatment. A multimodal approach with surgical resection followed by chemotherapy is preferred.

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Section: Discussionmentioning

confidence: 99%

Differentiating Primary Pancreatic Lymphoma Versus Primary Splenic Lymphoma: A Case Report

Ries

Jacovides

Rashti

et al. 2021

Journal of Pancreatic Cancer

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“…Less than 2% of patients with NHL have involvement of the pancreas upon presentation. 2 Extranodal lymphoma is classified as secondary if there is involvement of lymph nodes or if there is more than one extra nodal site. Secondary involvement of the pancreas is more common than primary pancreatic lymphoma; however, the overall involvement of the pancreas is rare.…”

Section: Discussionmentioning

confidence: 99%

“…NHL usually originates in the lymph nodes, but can also present in primary extranodal sites, such as the stomach, skin, lungs, and rarely, the pancreas. 1,2 NHL can be a result of proliferation of B-cells, T-cells, or both, with B-cell lymphoma being more common than T-cell. 3 This case presents a rare example of B-cell NHL originating from the pancreas tail.…”

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confidence: 99%

Extranodal Non-Hodgkin Lymphoma: A Rare Presentation Involving the Pancreas

Cerwin

2021

Journal of Diagnostic Medical Sonography

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Non-Hodgkin lymphoma (NHL) is a cancer of the immune system, and accounts for 90% of all lymphomas. When lymphoma is discovered outside of the immune system, it is considered extranodal lymphoma. Any organ can be the primary site of NHL, with the gastrointestinal tract being the most common site of involvement. This case study explores the sonographic discovery of an uncommon presentation of NHL with an extranodal mass originating from the pancreatic body and tail, and further extending into the splenic hilum.

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“…Radiologically, the lesions of PPL appear as focal and well-defined lesions or diffuse infiltration of pancreas ( 153 ), as summarized in Table 2 . The tumor is most commonly located in the head of the pancreas, though it can be found in other portions of the pancreas, such as the body and tail ( 149 , 154 ). PPL almost presents as bulky masses with a median size of 7.9 cm ( 155 ).…”

Section: Primary Pancreatic Lymphomamentioning

confidence: 99%

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

Wang

Wu²,

Zhang³

et al. 2022

Front. Oncol.

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Primary hepatopancreatobiliary lymphoma (PHPBL) is extremely rare, which is defined as a lympho-proliferative disease confined to the hepatobiliary system and pancreas without any involvement of lymph nodes, bone marrow, or other organs. The clinical and imaging manifestations of PHPBL are variable and non-special, which are akin to those of tumors of the hepatobiliary and pancreatic systems. The overall prognosis and management of PHPBL differ from those of other tumors in the hepatobiliary system and pancreas. Proper diagnosis and prompt treatment are essential for improving clinical outcomes. Due to its rarity, the optimal treatment has not been issued. However, combination chemotherapy is considered as a standard treatment for them. This review provides an overview of the pathogenesis, diagnosis, pathology, and management of PHPBL and offers clinicians the diagnosis and management schedule for PHPBL.

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Primary Pancreatic Lymphoma: An Uncommon Presentation in the Pancreatic Tail

Cited by 9 publications

References 13 publications

Differentiating Primary Pancreatic Lymphoma Versus Primary Splenic Lymphoma: A Case Report

Differentiating Primary Pancreatic Lymphoma Versus Primary Splenic Lymphoma: A Case Report

Extranodal Non-Hodgkin Lymphoma: A Rare Presentation Involving the Pancreas

Primary hepatopancreatobiliary lymphoma: Pathogenesis, diagnosis, and management

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