Cutaneous T-cell lymphoma and atopy: is there an association?

Mehrany, Khosrow; el-Azhary, Rokea A.; Bouwhuis, Saskia A.; Pittelkow, Mark R.

doi:10.1111/j.1365-2133.2003.05551.x

Cited by 38 publications

(27 citation statements)

References 36 publications

(75 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the clinical and histologic differential diagnosis between CTCL and AD is sometimes very difficult. In addition, cases with CTCL proceeded by AD have been reported (6,7). We have reported that both CTCL and AD patients show elevated serum levels of CC chemokine ligand (CCL) 17, CCL27, CCL11, and CCL26, which may help explain some of the similar clinical, laboratory, and histologic features of these 2 diseases (8)(9)(10)(11)(12).…”

Section: Mycosis Fungoides (Mf) and Sezary Syndrome (Ss) Are The Mostmentioning

confidence: 81%

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Miyagaki

Sugaya

Suga

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

Purpose: Both patients with cutaneous T-cell lymphoma (CTCL) and those with atopic dermatitis (AD) have pruritus, T H 2-biased T cells, and a tendency to have bacterial infections, suggesting a common pathologic basis for these two diseases. Recently, interleukin (IL)-22-producing T cells were reported in skin of patients with AD. In this study, we investigated expression levels of T H 22-and T H 17-related molecules in lesional skin and sera isolated from patients with CTCL.Experimental Design: Skin biopsies and sera were collected from patients with CTCL or psoriasis and from healthy volunteers. Protein and mRNA expression levels of IL-22, IL-17A, IL-17F, IL-23p19, IL-10, IL-4, CCL20, CCR6, IL-8, and IL-20 were examined in lesional tissue and a subset of these molecules in sera. Phosphorylation of STAT3 was also assessed in lesional skin of CTCL and psoriasis by immunohistochemistry.Results: IL-22, IL-10, IL-4, CCL20, and CCR6 mRNA and protein levels, but not IL-17A, IL-17F, IL-23p19, IL-8, or IL-20, were significantly elevated in lesional skin of CTCL. Phosphorylation of STAT3 was detected in epidermis of CTCL skin. Moreover, serum IL-22, IL-10, and CCL20 levels were increased in CTCL and correlated with disease severity.Conclusions: Our results suggest that IL-22 is important in establishing the tumor microenvironment for CTCL. Enhanced expression of CCL20 may explain epidermal hyperplasia and migration of CCR6 þ cells, such as Langerhans cells, into lesional skin. Relatively low expression of IL-17 may explain the lack of neutrophils in lesions of CTCL, which correlates with bacterial infections that commonly occur in skin affected by CTCL. Clin Cancer Res; 17(24); 7529-38. Ó2011 AACR.

show abstract

Section: Mycosis Fungoides (Mf) and Sezary Syndrome (Ss) Are The Mostmentioning

confidence: 81%

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Miyagaki

Sugaya

Suga

et al. 2011

Clinical Cancer Research

View full text Add to dashboard Cite

show abstract

“…These agents, pimecrolimus and tacrolimus, are topical calcineurin inhibitor immunosuppressants (TCI) [1,2,3]. At the time of FDA marketing approval, concern was raised by the FDA that these agents might be associated with an increased risk of nonmelanoma skin cancer (NMSC) because oral versions of calcineurin inhibitors have been associated with an increased frequency of NMSC, especially in those who have received organ transplants [4, 5].…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Exposure to Topical Calcineurin Inhibitors and Skin Cancer in Adults

2007

View full text Add to dashboard Cite

Background: Two topical calcineurin inhibitors (TCI) are available for the treatment of atopic dermatitis and there has been concern that their use could be associated with an increased risk of nonmelanoma skin cancer (NMSC). Objective: To determine if TCI exposure is associated with an increased risk of NMSC in adults. Methods: A case-control study using a questionnaire mailed to 5,000 adults with dermatitis. Results: We received responses from 70.7% of those surveyed by mail. Overall, 25.7% reported exposure to TCI. TCI exposure was 14.4% for the cases and 30.7% for the controls. Our primary analysis was a comparison between those with NMSC and those without. The unadjusted odds ratio was 0.38 (0.31–0.47) and the adjusted (age, gender, previous NMSC, history of atopic dermatitis) was 0.54 (0.41–0.69). The odds ratio of association for NMSC decreased as the number of tubes used and the potency of the agent increased. Conclusion: This early study shows that TCI use is not associated with an increased risk of NMSC in adults.

show abstract

“…Two cases of Sezary syndrome concerning a young man with severe AD have been published [8, 9]. However, in a retrospective study including 157 cases of CTCL, Mehrany et al[ 10] concluded that the association between atopic eczema and CTCL was not significant.…”

Section: Discussionmentioning

confidence: 99%

Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

et al. 2006

View full text Add to dashboard Cite

Atopic dermatitis (AD) is not regarded as a predisposing condition for cutaneous T cell lymphoma. Cyclosporine (CsA) is an efficient therapy in AD, and its side effects, including lymphocytic proliferation, are rare at the low dose used in such cases. So far 3 cases of patients who developed cutaneous T cell lymphoma under CsA treatment for atopy have been described. An adult patient with a history of AD received CsA therapy because of an atypical flare-up of his eruption. He rapidly developed papular atypical lesions, then followed by the onset of a voluminous cutaneous tumor leading to the diagnosis of mycosis fungoides (MF) transformed in CD30+ large cell lymphoma with nodal and blood involvement. No improvement occurred after withdrawing of CsA, and he required a polychemotherapy and an allograft. This case illustrates the dramatic evolution of an MF under CsA given in the hypothesis of AD. It stresses the fact that skin biopsies should be taken in case of atypical AD to rule out MF and avoid such an aggressive evolution under immunosuppressive therapy.

show abstract

Cutaneous T-cell lymphoma and atopy: is there an association?

Cited by 38 publications

References 36 publications

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

IL-22, but Not IL-17, Dominant Environment in Cutaneous T-cell Lymphoma

Lack of Association between Exposure to Topical Calcineurin Inhibitors and Skin Cancer in Adults

Aggressive CD30 Large Cell Lymphoma after Cyclosporine Given for Putative Atopic Dermatitis

Contact Info

Product

Resources

About