Cutaneous T-cell lymphoma in skin of color

Hinds, Ginette A.; Heald, Peter

doi:10.1016/j.jaad.2008.10.031

Cited by 50 publications

(38 citation statements)

References 61 publications

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“…Patients with pigmented skin of phototype III or higher were found to be able to tolerate maximum levels of light exposure (20–30 min of UVA light) without showing photoxicity . This was similar for our patients, whose skin phototypes were all III or higher, with BB‐UVA phototherapy at 10 and 15 J/cm 2 /session producing a lower rate of phototoxic side‐effects.…”

Section: Discussionsupporting

confidence: 82%

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial

Mofty

Bosseila

Mashaly

et al. 2013

Clinical and Experimental Dermatology

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Section: Discussionsupporting

confidence: 82%

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial

Mofty

Bosseila

Mashaly

et al. 2013

Clinical and Experimental Dermatology

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“…[39] The unique morphology of MF lesions at presentation in Blacks warrants a careful diagnosis. This along with the higher incidence and aggressive course of MF among Blacks, makes further study of this disease among black patients important.…”

Section: Discussionmentioning

confidence: 99%

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

Imam

Shenoy

Flowers

et al. 2013

Leukemia & Lymphoma

110

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Using the United States Surveillance, Epidemiology and End Results (SEER) 17 dataset, we examined incidence and survival patterns for patients with cutaneous T-cell lymphomas (CTCLs) diagnosed following institution of the World Health Organization-European Organisation for Research and Treatment of Cancer (WHO-EORTC) classification. From 2005 to 2008, 2273 cases of CTCL were diagnosed. The age-adjusted incidence rate per 100,000 person-years for mycosis fungoides (MF) was 0.55 and for Sézary syndrome (SS) was 0.01. Incidence was higher among males (MF/SS male-to-female incidence rate ratio [IRR] 1.57) and black patients (MF black-to-white IRR 1.55). Black patients with CTCL were diagnosed at a younger age and black patients with MF/SS presented with advanced stage and had worse survival than white patients. In multiple-variable Cox-regression models, age > 60 (hazard ratio [HR] 4.78, 95% confidence interval [CI] 2.97-7.70), black race (HR 2.09, 95% CI 1.29-3.37) and advanced stage (HR 6.06, 95% CI 3.66-10.05) predicted worse survival for patients with MF/SS. Additional research identifying reasons for these differences are necessary to better understand these diseases and for new strategies in the treatment of CTCL.

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“…[13] Classic lesions include arcuate scaly, poikilodermatous, atrophic, and polymorphic plaques. The predominant classic lesions in our patients were polymorphic plaques.…”

Section: Discussionmentioning

confidence: 99%

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

et al. 2016

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Background:Little data are available concerning clinical and pathological patterns of cutaneous lymphomas in India.Aim:To analyze the clinical and histopathological characteristics of cutaneous lymphomas in Indian patientsMaterials and Methods:This is a single-center, prospective, observational study carried out from January 1, 2010, to December 31, 2015. The patients underwent clinical examination, human T-cell lymphotropic virus-1 (HTLV-1) screening, skin biopsy with hematoxylin and eosin and immunohistochemistry staining.Results:Among 35 cases, 33 (94.3%) were T-cell, and 2 (5.7%) were B-cell lymphomas. The mean age was 52.66, and the male to female ratio was 2.5:1. The most common types of T-cell lymphomas included mycosis fungoides (MF) (57.1%) followed by adult T-cell lymphoma/leukemia (ATL) (17.1%). Primary cutaneous peripheral T-cell lymphoma not otherwise specified was diagnosed in 17.1% and anaplastic large cell lymphoma in 2.9%. The morphological types of MF included polymorphic, poikilodermatous, folliculotropic, hypopigmented, hyperpigmented, mixed, and purpuric. Skin manifestations of ATL included ulcerated plaques and erythroderma. Epidermotropism was very marked in ATL (83.3%) than in MF (70%). Larger Pautrier's microabscess was noted in ATL compared to smaller ones in MF. Markedly dense, diffuse infiltrate of atypical cells was noted in ATL in contrast to mild to moderate nodular or perivascular infiltrate in MF. ATL had an extremely poor prognosis.Limitations:Identification of DNA integration of HTLV-1 by Southern blot could not be analyzed, and the number of cases studied is limited.Conclusions:The study showed unique patterns of subtypes of cutaneous lymphomas in our country. Variations in the clinical pattern and histopathological analysis will help to differentiate T-cell lymphoma types which have prognostic implications.

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Cutaneous T-cell lymphoma in skin of color

Cited by 50 publications

References 61 publications

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial

Broadband ultraviolet A vs. psoralen ultraviolet A in the treatment of vitiligo: a randomized controlled trial

Incidence and survival patterns of cutaneous T-cell lymphomas in the United States

A clinicopathological analysis of primary cutaneous lymphomas: A 6-year observational study at a tertiary care center of south India

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