Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model

Alkhalil, Abdulnaser; Ball, Robert L.; Garg, Gaurav; Day, Anna; Carney, Bonnie C; Kumar, Raina; Hammamieh, Rasha; Moffatt, Lauren T.; Shupp, Jeffrey W.

doi:10.1093/jbcr/iraa209

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…A recent publication from MedStar Washington Hospital Burn Center identified burn-specific changes in murine sera and skin samples [ 24 ]. Skin changes affected inositol phosphate, ascorbate, alderate and caffeine metabolism, and the pentose phosphate pathway; such alterations were more delayed and less synchronous when compared to those detected in sera.…”

Section: Resultsmentioning

confidence: 99%

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Paganelli

Righi

Tarentini³

et al. 2022

IJMS

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Metabolomic profiling is an emerging field consisting of the measurement of metabolites in a biological system. Since metabolites can vary in relation to different stimuli, specific metabolic patterns can be closely related to a pathological process. In the dermatological setting, skin metabolomics can provide useful biomarkers for the diagnosis, prognosis, and therapy of cutaneous disorders. The main goal of the present review is to present a comprehensive overview of the published studies in skin metabolomics. A search for journal articles focused on skin metabolomics was conducted on the MEDLINE, EMBASE, Cochrane, and Scopus electronic databases. Only research articles with electronically available English full text were taken into consideration. Studies specifically focused on cutaneous microbiomes were also excluded from the present search. A total of 97 papers matched all the research criteria and were therefore considered for the present work. Most of the publications were focused on inflammatory dermatoses and immune-mediated cutaneous disorders. Skin oncology also turned out to be a relevant field in metabolomic research. Only a few papers were focused on infectious diseases and rarer genetic disorders. All the major metabolomic alterations published so far in the dermatological setting are described extensively in this review.

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Section: Resultsmentioning

confidence: 99%

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Paganelli

Righi

Tarentini³

et al. 2022

IJMS

View full text Add to dashboard Cite

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“…The changes in levels of metabolites observed in this cohort were consistent with previous studies demonstrating a significant increase in the turnover of arginine, ornithine, proline and leucine that appears specific to post-burn injury 13 . Alanine and increased levels of plasma aromatic amino acids have also been associated with burn injury but are altered after other trauma types, suggesting these changes may be associated with a more general stress response 14 .…”

Section: Discussionmentioning

confidence: 99%

Systemic long-term metabolic effects of acute non-severe paediatric burn injury

Begum

Johnson

Morillon

et al. 2022

Sci Rep

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A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In this study, to understand the long-term systemic effects of non-severe burns in children, targeted mass spectrometry assays for biogenic amines and tryptophan metabolites were performed on plasma collected from child burn patients at least three years post injury and compared to age and sex matched non-burn (healthy) controls. A panel of 12 metabolites, including urea cycle intermediates, aromatic amino acids and quinolinic acid were present in significantly higher concentrations in children with previous burn injury. Correlation analysis of metabolite levels to previously measured cytokine levels indicated the presence of multiple cytokine-metabolite associations in the burn injury participants that were absent from the healthy controls. These data suggest that there is a sustained immunometabolic imprint of non-severe burn trauma, potentially linked to long-term immune changes that may contribute to the poor long-term health outcomes observed in children after burn injury.

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Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu

Cai

et al. 2023

Sig Transduct Target Ther

234

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Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension, are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers could lead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity and selectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolic biomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeutic potentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathways changes as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists have established a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutic target exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-molecule candidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening and treatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

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Cutaneous Thermal Injury Modulates Blood and Skin Metabolomes Differently in a Murine Model

Cited by 3 publications

References 54 publications

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Current Knowledge in Skin Metabolomics: Updates from Literature Review

Systemic long-term metabolic effects of acute non-severe paediatric burn injury

Small molecule metabolites: discovery of biomarkers and therapeutic targets

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