Cutaneous warts clinical, histologic, and virologic correlations

Jabłońska, S; Orth, Gérard; Obalek, Slavomir; Croissant, O

doi:10.1016/0738-081x(85)90051-3

Clinics in Dermatology

1985

DOI: 10.1016/0738-081x(85)90051-3

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Cutaneous warts clinical, histologic, and virologic correlations

S Jabłońska

Gérard Orth

Slavomir Obalek

et al.

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Cited by 117 publications

(63 citation statements)

References 18 publications

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“…Common, plantar, and flat warts are induced by representatives of genera Alphapapillomavirus, Gammapapillomavirus, Mupapillomavirus, and Nupapillomavirus most frequently in children and adolescents 12 to 16 years of age (13). Beta-HPV causes flat warts and red-brown plaque-like and pityriasis versicolor-like lesions in patients with epidermodysplasia verruciformis but no characteristic pathology in the general population (14).…”

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confidence: 99%

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses

Weissenborn

Koning

Wieland

et al. 2009

J Virol

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Cutaneous human betapapillomaviruses (beta-HPVs) are widespread in the general population and have been associated with skin cancer. To evaluate the impact of continuous person-to-person contact within families on an individual's beta-HPV type spectrum, we collected serial skin swab samples from parents and children from 10 families. All participants were found to be beta-HPV DNA positive, with 1 to 13 types at study entry (median, 4.0 types). Initial and cumulative (2 to 16 types) HPV type multiplicities varied widely between different families but only a little between family members. The high intrafamilial correlation of HPV multiplicity is already obvious for babies aged 10 days to 10 months. Family members typically displayed similar spectra of HPV types. More than 75% of the HPV types in babies were also detected in their parents. This indicates that HPV transmission mainly results from close contact between family members. Type-specific persistence for at least 9 months was more prevalent in parents (92%) than in children (66%). Of the types detected throughout the study, 24% turned out to persist in the parents and only 11% in the children. Interestingly, about one-half of the HPV types found to persist in one of the parents occurred less frequently or even only sporadically in the spouse. Similarly, only one-third of the persisting parental types also persisted in their children. This indicates that even regular exposure to cutaneous HPV does not necessarily lead to the establishment of a persistent infection, which may point to type-specific susceptibilities of different individuals.Cutaneous human papillomaviruses (HPV) cluster in the genera Betapapillomavirus (beta-HPV), Gammapapillomavirus, Mupapillomavirus, and Nupapillomavirus of the family Papillomaviridae, and several types are classified in genus Alphapapillomavirus together with mostly mucosal types (7). Common, plantar, and flat warts are induced by representatives of genera Alphapapillomavirus, Gammapapillomavirus, Mupapillomavirus, and Nupapillomavirus most frequently in children and adolescents 12 to 16 years of age (13). Beta-HPV causes flat warts and red-brown plaque-like and pityriasis versicolor-like lesions in patients with epidermodysplasia verruciformis but no characteristic pathology in the general population (14). Clinically inapparent infections by members of genera beta-HPV and Gammapapillomavirus have been found to be extremely widespread in the general population when testing skin swabs or plucked eyebrow hairs for HPV DNA (1, 3, 4). These HPV types seem to be acquired already in the first days of life (2), but everybody will be exposed throughout life to multiple beta-HPV and gamma-HPV types in view of their high prevalence.Follow-up studies showed that a part of the transmitted HPV is able to establish persistent infections in the new host. Type-specific persistence was observed over 5 to 7 years in forehead skin and for up to 24 months in eyebrow hairs (6, 10).Beta-HPVs deserve special interest because of compelling evidenc...

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mentioning

confidence: 99%

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses

Weissenborn

Koning

Wieland

et al. 2009

J Virol

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“…Although some genotypes of HPV may be considered benign, as they cause common dermal warts (Jablonska et al, 1985), genotypes 16, 18, 31, 33 and others have been implicated in the pathogenesis of squamous epithelial neoplasms (Ostrow et al, 1987), including cervical dysplasia and invasive cervical cancer (Koutsky ei al., 1988), anal carcinoma (zur Hausen, 19896;Beckman et al, 1989), and perhaps bronchial carcinoma (Byme et al, 1987;Syrjanen et al, 1987). Furthermore, HPV infection of the ano-genital tract is frequent in both males and females, and some HPV are sexually transmitted (Koutsky et al, 1988).…”

mentioning

confidence: 99%

Interaction of human immunodeficiency and papilloma viruses: Association with anal epithelial abnormality in homosexual men

Caussy¹,

Goedert²,

Palefsky

et al. 1990

Intl Journal of Cancer

105

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“…Instead of intracytoplasmic inclusion bodies and vacuolar structures, the histological features of the HPV-57-associated cysts were like those of the HPV-2-specific cytopathic effect (Gross et al, 1982 ;Jablonska et al, 1985). We have previously found a plantar epidermoid cyst with inverted growth, which histologically showed HPV-2-related features (Egawa et al, 1993 b), and we identified an HPV-57 DNA fragment using PCR (Egawa et al, 1998).…”

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confidence: 99%

A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies.

Kitasato

Egawa

Honda

et al. 1998

Journal of General Virology

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Human papillomavirus type 60 (HPV-60) is the only virus type that has been identified in epidermoid cysts. In this study, HPV-57 DNA was found in three out of 18 plantar epidermoid cysts with different histological features from HPV-60-associated cysts, using PCR and Southern hybridization. The HPV-57-associated cysts had features resembling an HPV-2-specific cytopathic effect. The sequences of two HPV-57 DNA clones isolated from two patients were identical, but differed at some positions from those of HPV-57a and HPV-57b. This putative new subtype was tentatively designated as HPV-57c, and may be associated with plantar epidermoid cysts showing histological features resembling the HPV-2 cytopathic effect.Human papillomavirus (HPV) has recently been identified frequently in palmoplantar epidermoid cysts (Egawa et al., 1987(Egawa et al., , 1990(Egawa et al., , 1995Kimura et al., 1987 ;Matsukura et al., 1992), suggesting that HPV may play a role in the pathogenesis of these cysts, and HPV-60 is the only HPV type that has been identified in epidermoid cysts so far (Matsukura et al., 1992 ; Egawa et al., 1994 Egawa et al., , 1995Kawase et al., 1994). It has also been well-established that homogeneous intracytoplasmic inclusion bodies in the cyst wall and vacuolar structures in the cyst cavity are pathognomonic for HPV-60 infection in the cysts (Matsukura et al., 1992 ; Egawa et al., 1993 Egawa et al., a, 1994 Egawa et al., , 1995.Here we have isolated a putative new HPV-57 subtype from plantar epidermoid cysts using PCR and Southern 9349. e-mail hkita!med.kitasato-u.ac.jp hybridization. Instead of intracytoplasmic inclusion bodies and vacuolar structures, the histological features of the HPV-57-associated cysts were like those of the HPV-2-specific cytopathic effect (Gross et al., 1982 ;Jablonska et al., 1985). We have previously found a plantar epidermoid cyst with inverted growth, which histologically showed HPV-2-related features (Egawa et al., 1993 b), and we identified an HPV-57 DNA fragment using PCR (Egawa et al., 1998). To establish whether that was an isolated finding or a reflection of a close relationship between HPV-57 and plantar epidermoid cysts, we searched for HPV-57 in 18 plantar epidermoid cysts with histological features similar to those of the first HPV-57-related case, using PCR and Southern hybridization. Sequencing analysis of the amplified HPV-57 DNA fragments was also performed and sequences of cysts were compared with each other and with those of two reported HPV-57 subtypes, HPV-57a and HPV57b.Sections (4 µm) were serially prepared from formalin-fixed and paraffin-embedded specimens of the 18 epidermoid cysts and were stained with haematoxylin-eosin for conventional histological studies. On microscopy, instead of intracytoplasmic homogeneous inclusion bodies in the cyst wall or vacuolar structures within the keratinous mass, which are pathognomonic for HPV-60-related epidermoid cysts, the characteristic histological features of these cysts were vacuolated cells or condensed kera...

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Cutaneous warts clinical, histologic, and virologic correlations

Cited by 117 publications

References 18 publications

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses

Interaction of human immunodeficiency and papilloma viruses: Association with anal epithelial abnormality in homosexual men

A putative human papillomavirus type 57 new subtype isolated from plantar epidermoid cysts without intracytoplasmic inclusion bodies.

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